Combustion synthesis and spark plasma sintering of apatite-tricalcium phosphate nanocomposites

Angioni, Damiano; Orrù, Roberto; Cao, Giacomo; Garroni, Sebastiano; Ricci, Pier Carlo; Manukyan, Khachatur V.

doi:10.1016/j.ceramint.2023.05.219

Cited by 2 publications

(1 citation statement)

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“…For example, in the 1980s, BCPs were called "TCP ceramics complexed with HA" [1124]. Even today, such multiphasic formulations are sometimes referred to as nanocomposites [1125,1126] or simply composites [1127]. Furthermore, fluorinated HA (chemical formula Ca 10 (PO 4 ) 6 (OH) 2−x F x , where 0 < x < 2) can also be listed as a composite material [1128], although it is debatable whether the term 'composite' can be applied to such a system.…”

Section: Biocomposites From Capo 4 Onlymentioning

confidence: 99%

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Dorozhkin

2024

J. Compos. Sci.

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The goal of this review is to present a wide range of hybrid formulations and composites containing calcium orthophosphates (abbreviated as CaPO4) that are suitable for use in biomedical applications and currently on the market. The bioactive, biocompatible, and osteoconductive properties of various CaPO4-based formulations make them valuable in the rapidly developing field of biomedical research, both in vitro and in vivo. Due to the brittleness of CaPO4, it is essential to combine the desired osteologic properties of ceramic CaPO4 with those of other compounds to create novel, multifunctional bone graft biomaterials. Consequently, this analysis offers a thorough overview of the hybrid formulations and CaPO4-based composites that are currently known. To do this, a comprehensive search of the literature on the subject was carried out in all significant databases to extract pertinent papers. There have been many formulations found with different material compositions, production methods, structural and bioactive features, and in vitro and in vivo properties. When these formulations contain additional biofunctional ingredients, such as drugs, proteins, enzymes, or antibacterial agents, they offer improved biomedical applications. Moreover, a lot of these formulations allow cell loading and promote the development of smart formulations based on CaPO4. This evaluation also discusses basic problems and scientific difficulties that call for more investigation and advancements. It also indicates perspectives for the future.

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Section: Biocomposites From Capo 4 Onlymentioning

confidence: 99%

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Dorozhkin

2024

J. Compos. Sci.

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Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering

Radulescu,

Vasile,

Andronescu

et al. 2023

IJMS

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Bone tissue engineering has attracted great interest in the last few years, as the frequency of tissue-damaging or degenerative diseases has increased exponentially. To obtain an ideal treatment solution, researchers have focused on the development of optimum biomaterials to be applied for the enhancement of bioactivity and the regeneration process, which are necessary to support the proper healing process of osseous tissues. In this regard, hydroxyapatite (HA) has been the most widely used material in the biomedical field due to its great biocompatibility and similarity with the native apatite from the human bone. However, HA still presents some deficiencies related to its mechanical properties, which are essential for HA to be applied in load-bearing applications. Bioactivity is another vital property of HA and is necessary to further improve regeneration and antibacterial activity. These drawbacks can be solved by doping the material with trace elements, adapting the properties of the material, and, finally, sustaining bone regeneration without the occurrence of implant failure. Considering these aspects, in this review, we have presented some general information about HA properties, synthesis methods, applications, and the necessity for the addition of doping ions into its structure. Also, we have presented their influence on the properties of HA, as well as the latest applications of doped materials in the biomedical field.

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Combustion synthesis and spark plasma sintering of apatite-tricalcium phosphate nanocomposites

Cited by 2 publications

References 41 publications

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering

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