Commensal microbe-derived propionic acid mediates juvenile social isolation-induced social deficits and anxiety-like behaviors

Huang, Ling; Duan, Chengxing; Xia, Xiuwen; Wang, Huaifu; Wang, Yili; Zhong, Zhanqiong; Wang, Baojia; Ding, Weijun; Yang, Youjun

doi:10.1016/j.brainresbull.2020.12.001

Cited by 18 publications

(12 citation statements)

References 62 publications

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“…It has been previously reported that the increase of acetic acid in the intestine greatly affected the metabolism of glycolipids and fatty acids, thus controlling the homeostasis of colonic Treg cells ( Smith et al, 2013 ). It was also found that propionic acid could inhibit the biosynthesis of cholesterol and fatty acids in mouse liver ( Liang et al, 2019 ), and improve social behavior disorders and cognitive functions impairment by crossing intestinal-blood and blood-brain barriers ( Huang et al, 2021c ). Butyric acid plays an important role in regulating the lipid metabolism and is helpful to decrease the risk of lipid metabolism disorder in liver ( Skariyachan and Bs, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake

Guo

Cao

You

et al. 2022

Current Research in Food Science

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Section: Resultsmentioning

confidence: 99%

Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake

Guo

Cao

You

et al. 2022

Current Research in Food Science

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“…SCFAs seem to be beneficial to health by maintaining intestinal epithelial integrity, reducing inflammation, and enhancing immune function. However, recent studies found that juvenile social isolated mice showed anxiety-like behaviors, which may be mediated by gut-derived propionic acid decreasing the expression of oxytocin receptors in the medial prefrontal cortex ( Huang et al., 2021 ). Roseburia was overrepresented in healthy controls compared to patients with major depressive disorder ( Zheng et al., 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiome and Metabolome Changes in Mice With Acute Vestibular Deficit

Feng

Liu

et al. 2022

Front. Cell. Infect. Microbiol.

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Vestibular deficit is a very common disorder in clinical practice and is characterized by vertigo, spontaneous nystagmus, and autonomic nervous symptoms, including nausea, vomiting, and sweating. In addition, the comorbidity of vestibular deficit and anxiety has long been an integral component of the medical literature. Previous studies have suggested that the mechanisms underlying this comorbidity involved overlap of vestibular and cerebellar networks. Emerging evidence has shown that the microbiota–gut–brain axis plays a key role in the regulation of affective disorders. Thus, we hypothesized that the gut microbiota may be involved in the comorbidity of vestibular deficit and anxiety. To verify this, we constructed a unilateral labyrinthectomy mouse model to simulate vestibular deficit. Then, 16S rRNA gene sequencing and liquid chromatography–mass spectrometry (LC-MS) were used to analyze the microbiome and metabolome of the cecal samples collected from mice in the unilateral labyrinthectomy, sham surgery, and control groups. Notably, unilateral labyrinthectomy shaped the composition of the mouse gut microbiome, resulting in increased abundance of Lachnospiraceae NK4A136 group, Odoribacter and Roseburia and decreased abundance of Prevotella and Parasutterella at the genus level. Tax4Fun functional prediction indicated a decrease in tryptophan metabolism in mice in the unilateral labyrinthectomy group. Moreover, functional correlation of changes in gut microbes and metabolites between different groups showed that the oleamide level was negatively correlated with Odoribacter abundance (r = -0.89, p = 0.0002). The butyric acid level was positively correlated with Parasutterella abundance (r = 0.85, p = 0.0010). The propanoate level was negatively correlated with Prevotella abundance (r = -0.81, p = 0.0020). The 20-HETE level was positively correlated with Parasutterella abundance (r = 0.84, p = 0.0013). The altered microbes and metabolites were closely related to the pathogenesis of affective disorders. Our results not only offer novel insights into the vestibular deficit comorbid with anxiety but also build an important basis for future research on this etiology.

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“…QIIME1.8.0 was used for classification allocation and sparseness, using approximately 80,000 readings per sample. 24 The OTUs of each sample were classified and annotated in the Silva reference database (version 138). The Shannon index of the microbial community was calculated by QIIME software (version 1.9.1).…”

Section: Methodsmentioning

confidence: 99%

Lingguizhugan Decoction Targets Intestinal Microbiota and Metabolites to Reduce Insulin Resistance in High-Fat Diet Rats

Ning¹,

Gong²,

Zheng³

et al. 2022

DMSO

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Background The increasing incidence of obesity and its complications has become a global public health problem. Lingguizhugan decoction (LGZGD) is a representative compound of traditional Chinese medicine (TCM) for metabolic diseases, such as nonalcoholic fatty liver disease, but its role in insulin resistance (IR) treatment is still less known. This study aims to evaluate the therapeutic properties of LGZGD on obesity-induced IR and explore the potential mechanism of LGZGD on gut microbiota and its metabolites in the treatment of IR. Methods In this study, we induced an IR model in the form of high-fat diet (HFD) rats gavaged with LGZGD (1.64 g/kg BW) for three weeks. The IR status was measured by biochemical assays and oral glucose tolerance tests. The degrees of damage to liver function and the intestinal barrier were observed by hematoxylin and eosin (H&E) staining and immunohistochemistry. Alterations in intestinal microbiota and metabolites were assessed by 16S rRNA and an untargeted metabolomics platform. Results Our results showed that after LGZGD treatment, the body weight, plasma insulin concentration and blood lipids were significantly decreased, and glucose tolerance and hepatic steatosis were ameliorated. In addition, small intestinal villi were restored, and the expression of Occludin was upregulated. The relative abundance of Akkermansia, Faecalibacterium and Phascolarctobacterium in the HFD-LGZG group was upregulated. Obesity-related metabolic pathways, such as bile secretion, biosynthesis of amino acids, phenylalanine metabolism, serotonergic synapse, protein digestion and absorption, taurine and hypotaurine metabolism, and primary bile acid biosynthesis, were changed. After LGZGD intervention, metabolites developed toward the healthy control group. In addition, the expression of bile acid metabolism related genes was also regulated in IR rats. Conclusion We showed that LGZGD relieved IR, possibly by regulating the composition of the fecal microbiota and its metabolites. The above studies provide a basis for further study of LGZGD in the treatment of IR and its clinical application.

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Commensal microbe-derived propionic acid mediates juvenile social isolation-induced social deficits and anxiety-like behaviors

Cited by 18 publications

References 62 publications

Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake

Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake

Gut Microbiome and Metabolome Changes in Mice With Acute Vestibular Deficit

Lingguizhugan Decoction Targets Intestinal Microbiota and Metabolites to Reduce Insulin Resistance in High-Fat Diet Rats

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