Comment on an article: “Medications in COVID-19 patients: summarizing the current literature from an orthopaedic perspective”

Ibrahimagić, Omer Ć.; Ercegovic, Zlatko; Vujadinović, Aleksandar; Kunić, Suljo

doi:10.1007/s00264-020-04782-9

Cited by 7 publications

(5 citation statements)

References 8 publications

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“…227 It has been suggested laboratory investigation for serum tHcy and B9/B12 in all patients affected by COVID-19 during hospitalization, for potential benefits of relative supplementation of micronutrients in terms of disease severity and vascular complications. 228 However, no supporting evidence for the potential detrimental effects of hyperhomocysteinemia on bone fragility in COVID-19 patients as well as of putative benefits of its correction by B9/B12 vitamins supplementation in terms of fragility fracture prevention is available so far.…”

Section: Nutritional Issues During the Covid-19 Pandemic And Their Co...mentioning

confidence: 99%

Bone fragility during the COVID-19 pandemic: the role of macro- and micronutrients

Moretti

Liguori

Paoletta

et al. 2023

Therapeutic Advances in Musculoskeletal

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Bone fragility is the susceptibility to fracture due to poor bone strength. This condition is usually associated with aging, comorbidities, disability, poor quality of life, and increased mortality. International guidelines for the management of patients with bone fragility include a nutritional approach, mainly aiming at optimal protein, calcium, and vitamin D intakes. Several biomechanical features of the skeleton, such as bone mineral density (BMD), trabecular and cortical microarchitecture, seem to be positively influenced by micro- and macronutrient intake. Patients with major fragility fractures are usually poor consumers of dairy products, fruit, and vegetables as well as of nutrients modulating gut microbiota. The COVID-19 pandemic has further aggravated the health status of patients with skeletal fragility, also in terms of unhealthy dietary patterns that might adversely affect bone health. In this narrative review, we discuss the role of macro- and micronutrients in patients with bone fragility during the COVID-19 pandemic.

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Section: Nutritional Issues During the Covid-19 Pandemic And Their Co...mentioning

confidence: 99%

Bone fragility during the COVID-19 pandemic: the role of macro- and micronutrients

Moretti

Liguori

Paoletta

et al. 2023

Therapeutic Advances in Musculoskeletal

View full text Add to dashboard Cite

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“…Considering the absence of medicine specifically formulated to combat COVID-19 infection, several pharmaceutical interventions have been put into a clinical trial or implemented to symptomatically treat COVID-19 patients (Ibrahimagić et al 2020 ; Anand et al 2021a , b , c , d ). With the looming paranoia about the health risk brought about by the pandemic, self-medication among the population has increased, in the hope of preventing COVID-19 infection or relieving symptoms, they experience (Malik et al 2020 ).…”

Section: Occurrencementioning

confidence: 99%

Occurrence, transformation, bioaccumulation, risk and analysis of pharmaceutical and personal care products from wastewater: a review

et al. 2022

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Almost all aspects of society from food security to disease control and prevention have benefited from pharmaceutical and personal care products, yet these products are a major source of contamination that ends up in wastewater and ecosystems. This issue has been sharply accentuated during the coronavirus disease pandemic 2019 (COVID-19) due to the higher use of disinfectants and other products. Here we review pharmaceutical and personal care products with focus on their occurrence in the environment, detection, risk, and removal.

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“…6 Moreover, paracetamol has been considered the first choice analgesic and antipyretic used for COVID-19 patients considering the WHO pain management ladder. 7 Consequently, these concerns have intensified during the COVID-19 pandemic because of the exceptionally excessive purchase and domiciliary use without considering the safety measures. 8 After a paracetamol overdose, cytochrome P450 isoenzymes bioactivate the excess paracetamol to a hepatotoxic metabolite, N-acetyl-p-benzoquinoneimine (NAPQI).…”

Section: Introductionmentioning

confidence: 99%

“…The WHO urged people on March 17, 2020, with coronavirus disease 2019 (COVID-19) symptoms to avoid ibuprofen and instead utilize paracetamol . Moreover, paracetamol has been considered the first choice analgesic and antipyretic used for COVID-19 patients considering the WHO pain management ladder . Consequently, these concerns have intensified during the COVID-19 pandemic because of the exceptionally excessive purchase and domiciliary use without considering the safety measures …”

Section: Introductionmentioning

confidence: 99%

Taming Food–Drug Interaction Risk: Potential Inhibitory Effects of Citrus Juices on Cytochrome Liver Enzymes Can Safeguard the Liver from Overdose Paracetamol-Induced Hepatotoxicity

et al. 2023

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Paracetamol overdose is the leading cause of druginduced hepatotoxicity worldwide. Because of N-acetyl cysteine's limited therapeutic efficacy and safety, searching for alternative therapeutic substitutes is necessary. This study investigated four citrus juices: Citrus sinensis L. Osbeck var. Pineapple (pineapple sweet orange), Citrus reticulata Blanco × Citrus sinensis L. Osbeck (Murcott mandarin), Citrus paradisi Macfadyen var. Ruby Red (red grapefruit), and Fortunella margarita Swingle (oval kumquat) to improve the herbal therapy against paracetamol-induced liver toxicity. UHPLC-QTOF-MS/MS profiling of the investigated samples resulted in the identification of about 40 metabolites belonging to different phytochemical classes. Phenolic compounds were the most abundant, with the total content ranked from 609.18 to 1093.26 μg gallic acid equivalent (GAE)/mL juice. The multivariate data analysis revealed that phloretin 3′,5′-di-C-glucoside, narirutin, naringin, hesperidin, 2-O-rhamnosyl-swertisin, fortunellin (acacetin-7-O-neohesperidoside), sinensetin, nobiletin, and tangeretin represented the crucial discriminatory metabolites that segregated the analyzed samples. Nevertheless, the antioxidant activity of the samples was 1135.91−2913.92 μM Trolox eq/mL juice, 718.95−3749.47 μM Trolox eq/mL juice, and 2304.74− 4390.32 μM Trolox eq/mL juice, as revealed from 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulfonic acid, ferric-reducing antioxidant power, and oxygen radical absorbance capacity, respectively. The in vivo paracetamol-induced hepatotoxicity model in rats was established and assessed by measuring the levels of hepatic enzymes and antioxidant biomarkers. Interestingly, the concomitant administration of citrus juices with a toxic dose of paracetamol effectively recovered the liver injury, as confirmed by normal sections of hepatocytes. This action could be due to the interactions between the major identified metabolites (hesperidin, hesperetin, phloretin 3′,5′-di-C-glucoside, fortunellin, poncirin, nobiletin, apigenin-6,8-digalactoside, 6′,7′-dihydroxybergamottin, naringenin, and naringin) and cytochrome P450 isoforms (CYP3A4, CYP2E1, and CYP1A2), as revealed from the molecular docking study. The most promising compounds in the three docking processes were hesperidin, fortunellin, poncirin, and naringin. Finally, a desirable food−drug interaction was achieved in our research to overcome paracetamol overdose-induced hepatotoxicity.

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Comment on an article: “Medications in COVID-19 patients: summarizing the current literature from an orthopaedic perspective”

Cited by 7 publications

References 8 publications

Bone fragility during the COVID-19 pandemic: the role of macro- and micronutrients

Bone fragility during the COVID-19 pandemic: the role of macro- and micronutrients

Occurrence, transformation, bioaccumulation, risk and analysis of pharmaceutical and personal care products from wastewater: a review

Taming Food–Drug Interaction Risk: Potential Inhibitory Effects of Citrus Juices on Cytochrome Liver Enzymes Can Safeguard the Liver from Overdose Paracetamol-Induced Hepatotoxicity

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