Comment on Debaty et al.: Impact of intra-arrest therapeutic hypothermia in outcomes of prehospital cardiac arrest: a randomized controlled trial

Saigal, Saurabh; Sharma, Jai Prakash

doi:10.1007/s00134-014-3556-5

Cited by 2 publications

(1 citation statement)

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“…Thus, the results of this study cannot be generalized as the results of this trial pertain to a specific patient population who already has a poor prognosis. [ 42 ]…”

Section: Current Evidence and Practices In Critical Carementioning

confidence: 99%

Targeted temperature management: Current evidence and practices in critical care

Saigal

Sharma

Dhurwe

et al. 2015

Indian Journal of Critical Care Medicine

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Targeted temperature management (TTM) in today's modern era, especially in intensive care units represents a promising multifaceted therapy for a variety of conditions. Though hypothermia is being used since Hippocratic era, the renewed interest of late has been since early 21st century. There have been multiple advancements in this field and varieties of cooling devices are available at present. TTM requires careful titration of its depth, duration and rewarming as it is associated with side-effects. The purpose of this review is to find out the best evidence-based clinical practice criteria of therapeutic hypothermia in critical care settings. TTM is an unique therapeutic modality for salvaging neurological tissue viability in critically ill patients viz. Post-cardiac arrest, traumatic brain injury (TBI), meningitis, acute liver failure and stroke. TTM is standard of care in post-cardiac arrest situations; there has been a lot of controversy of late regarding temperature ranges to be used for the same. In patients with TBI, it reduces intracranial pressure, but has not shown any favorable neurologic outcome. Hypothermia is generally accepted treatment for hypoxic ischemic encephalopathy in newborns. The current available technology to induce and maintain hypothermia allows for precise temperature control. Future studies should focus on optimizing hypothermic treatment to full benefit of our patients and its application in other clinical scenarios.

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“…Thus, the results of this study cannot be generalized as the results of this trial pertain to a specific patient population who already has a poor prognosis. [ 42 ]…”

Section: Current Evidence and Practices In Critical Carementioning

confidence: 99%