Comment on: “Energetics and Kinetics of Thermal Ionization Models of MALDI” by Richard Knochenmuss. <b><i>J. Am. Soc. Mass Spectrom</i></b>. 25, 1521–1527 (2014)

Gray‐Weale, Angus; Ni, Chi-Kung

doi:10.1007/s13361-015-1197-8

Cited by 8 publications

(11 citation statements)

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“…Studies have demonstrated [10][11][12][13][14][15] that the amount of protonated ions generated by a thermally induced proton transfer reaction has an order of magnitude similar to that observed in experimental measurements.…”

Section: Introductionsupporting

confidence: 61%

“…Many studies on MALDI have discussed the procedures involved in generating these protonated peptides and proteins [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. Carbohydrate ions are generated in MALDI as sodiated or potassiated carbohydrates.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, we proposed a thermal proton transfer model to describe the generation of protonated ions in MALDI [10][11][12][13][14][15]. The absorption of laser light by matrix molecules results in an increased temperature, and the solid matrix melts and behaves in a similar manner to a polar solvent before the occurrence of desorption.…”

Section: Introductionmentioning

confidence: 99%

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Formation of Metal-Related Ions in Matrix-Assisted Laser Desorption Ionization

Lee

Hsu

et al. 2016

J. Am. Soc. Mass Spectrom.

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Abstract. In a study of the metal-related ion generation mechanism in matrix-assisted laser desorption ionization (MALDI), crystals of matrix used in MALDI were grown from matrix-and salt-containing solutions. The intensities of metal ion and metal adducts of the matrix ion obtained from unwashed crystals were higher than those from crystals washed with deionized water, indicating that metal ions and metal adducts of the matrix ions are mainly generated from the surface of crystals. The contributions of preformed metal ions and metal adducts of the matrix ions inside the matrix crystals were minor. Metal adducts of the matrix and analyte ion intensities generated from a mixture of dried matrix, salt, and analyte powders were similar to or higher than those generated from the powder of dried droplet crystals, indicating that the contributions of the preformed metal adducts of the matrix and analyte ions were insignificant. Correlation between metal-related ion intensity fluctuation and protonated ion intensity fluctuation was observed, indicating that the generation mechanism of the metal-related ions is similar to that of the protonated ions. Because the thermally induced proton transfer model effectively describes the generation of the protonated ions, we suggest that metal-related ions are mainly generated from the salt dissolution in the matrix melted by the laser.

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Section: Introductionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

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Formation of Metal-Related Ions in Matrix-Assisted Laser Desorption Ionization

Lee

Hsu

et al. 2016

J. Am. Soc. Mass Spectrom.

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“…However, the fraction of non-recombined ion from black sphere model is 10 -6 , which is 10 4 lower than that from molecular dynamics simulation. The black sphere model calculations contradict his early molecular dynamics simulation, as we pointed out in our early comments [3]. The reply did not answer the contradiction.…”

mentioning

confidence: 83%

“…T he majority of the issues raised in reference [1] are unchanged from the original paper [2], and we therefore address them here only briefly and refer the reader back to our comment [3].…”

mentioning

confidence: 99%

Comment to the Reply on: “Energetics and Kinetics of Thermal Ionization Models of MALDI” by Richard Knochenmuss. J. Am. Soc. Mass Spectrom. 25, 1521–1527 (2014)

Gray‐Weale

2015

J. Am. Soc. Mass Spectrom.

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Analysis of Carbohydrates and Glycoconjugates by Matrix‐assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2015–2016

Harvey

2021

Mass Spectrometry Reviews

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This review is the ninth update of the original article published in 1999 on the application of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2016. Also included are papers that describe methods appropriate to analysis by MALDI, such as sample preparation techniques, even though the ionization method is not MALDI. Topics covered in the first part of the review include general aspects such as theory of the MALDI process, matrices, derivatization, MALDI imaging, fragmentation and arrays. The second part of the review is devoted to applications to various structural types such as oligo‐ and poly‐saccharides, glycoproteins, glycolipids, glycosides and biopharmaceuticals. Much of this material is presented in tabular form. The third part of the review covers medical and industrial applications of the technique, studies of enzyme reactions and applications to chemical synthesis. The reported work shows increasing use of combined new techniques such as ion mobility and the enormous impact that MALDI imaging is having. MALDI, although invented over 30 years ago is still an ideal technique for carbohydrate analysis and advancements in the technique and range of applications show no sign of deminishing. © 2020 Wiley Periodicals, Inc.

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Comment on: “Energetics and Kinetics of Thermal Ionization Models of MALDI” by Richard Knochenmuss. J. Am. Soc. Mass Spectrom. 25, 1521–1527 (2014)

Cited by 8 publications

References 20 publications

Formation of Metal-Related Ions in Matrix-Assisted Laser Desorption Ionization

Formation of Metal-Related Ions in Matrix-Assisted Laser Desorption Ionization

Comment to the Reply on: “Energetics and Kinetics of Thermal Ionization Models of MALDI” by Richard Knochenmuss. J. Am. Soc. Mass Spectrom. 25, 1521–1527 (2014)

Analysis of Carbohydrates and Glycoconjugates by Matrix‐assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2015–2016

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