Comment on “Inositols: from physiology to rational therapy in gynecological clinical practice”

Laganà, Antonio Simone; Sapia, Fabrizio; Rosa, Valentina Lucia La; Vitale, Salvatore Giovanni

doi:10.1080/17425255.2016.1248598

Cited by 12 publications

(9 citation statements)

References 5 publications

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“…This agrees with the clinical evidence that reported the beneficial effect exerted by MI and DCI combined at 40:1 ratio in PCOS patients ( 51 , 52 ). Further investigations might be required as also suggested by other researchers ( 72 ).…”

Section: Discussionmentioning

confidence: 72%

Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials

Unfer¹,

Facchinetti

Orrù³

et al. 2017

Endocrine Connections

135

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Myo-inositol (MI) supplementation in women with polycystic ovary syndrome (PCOS) has been evaluated over the last years. Many hormonal and reproductive impairments associated with this disorder seem relieved by the supplement. The objective of the meta-analysis was to assess the effects of MI alone or combined with d-chiro-inositol (DCI) on the endocrine and metabolic abnormalities of women with PCOS. Literature was retrieved from selected databases, MEDLINE, EMBASE, PubMed and Research Gate (up to November 2016). Only randomized controlled trials (RCTs) investigating the effects of MI alone or combined with DCI were reviewed. Nine RCTs involving 247 cases and 249 controls were included. Significant decreases in fasting insulin (SMD = −1.021 µU/mL, 95% CI: −1.791 to −0.251, P = 0.009) and homeostasis model assessment (HOMA) index (SMD = −0.585, 95% CI: −1.145 to −0.025, P = 0.041) were identified after MI supplementation. The trial sequential analysis of insulin meta-analysis illustrates that the cumulative z-curve crossed the monitoring boundary, providing firm evidence of the intervention effect. A slight trend toward a reduction of testosterone concentration by MI with respect to controls was found (SMD = −0.49, 95% CI: −1.072 to 0.092, P = 0.099), whereas androstenedione levels remained unaffected. Throughout a subgroup’s meta-analysis, a significant increase in serum SHBG was observed only in those studies where MI was administered for at least 24 weeks (SMD = 0.425 nmol/L, 95% CI: 0.050–0.801, P = 0.026). These results highlight the beneficial effect of MI in improving the metabolic profile of women with PCOS, concomitantly reducing their hyperandrogenism.

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Section: Discussionmentioning

confidence: 72%

Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials

Unfer¹,

Facchinetti

Orrù³

et al. 2017

Endocrine Connections

135

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“…Recent studies have pointed out the importance of nutritional factors on gynaecological-related conditions [ 341 , 342 ]. In particular, the link between soy foods and menopause has been shown by clinical and epidemiological data [ 343 , 344 ].…”

Section: Health Effectsmentioning

confidence: 99%

Soy, Soy Foods and Their Role in Vegetarian Diets

Rizzo¹,

2018

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Soy is a basic food ingredient of traditional Asian cuisine used for thousands of years. In Western countries, soybeans have been introduced about a hundred years ago and recently they are mainly used for surrogate foods production. Soy and soy foods are common nutritional solutions for vegetarians, due to their high protein content and versatility in the production of meat analogues and milk substitutes. However, there are some doubts about the potential effects on health, such as the effectiveness on cardiovascular risk reduction or, conversely, on the possible disruption of thyroid function and sexual hormones. The soy components that have stimulated the most research interest are isoflavones, which are polyphenols with estrogenic properties highly contained in soybeans. In this review, we discuss the characteristics of soy and soy foods, focusing on their nutrient content, including phytoestrogens and other bioactive substances that are noteworthy for vegetarians, the largest soy consumers in the Western countries. The safety of use will also be discussed, given the growing trend in adoption of vegetarian styles and the new soy-based foods availability.

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“…Generally, PCOS affects women of childbearing age, and is accompanied by ovarian dysfunction, infertility, hyperinsulinemia, hyperandrogenism, and insulin resistance (IR) [ 3 – 5 ]. According to recent studies, metabolic disturbances are key factors of PCOS pathophysiology and different fasting regimens can have beneficial effects on ovarian function, androgen excess and infertility in women in PCOS [ 6 – 8 ]. In recent years, advances in modern medicine have positively reflected on the study of organ fibrosis in lung, liver, kidney and pancreas.…”

Section: Introductionmentioning

confidence: 99%

DHEA-induced ovarian hyperfibrosis is mediated by TGF-β signaling pathway

Wang

Qiao

et al. 2018

J Ovarian Res

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BackgroundThe polycystic ovary syndrome (PCOS) is a common metabolic and endocrine disorder with pathological mechanisms remain unclear. The following study investigates the ovarian hyperfibrosis forming via transforming growth factor-β (TGF-β) signaling pathway in Dehydroepiandrosterone (DHEA)- induced polycystic ovary syndrome (PCOS) rat model. We furthermore explored whether TGF-βRI inhibitor (SB431542) decreases ovarian fibrosis by counterbalancing the expression of fibrotic biomarkers.MethodsThirty female Sprague-Dawley rats were randomly divided into Blank group (n = 6), Oil group (n = 6), and Oil + DHEA-induced model group (n = 6 + 12). The model groups were established by subcutaneous injection of DHEA for 35 consecutive days. The 12 successful model rats were additionally divided in vehicle group (n = 6) and SB431542-treated group (n = 6). Vehicle group and SB431542-treated group, served as administration group and were intraperitoneally injected with DMSO and SB431542 for additional 14 consecutive days. Ovarian morphology, fibrin and collagen localization and expression in ovaries were detected using H&E staining, immunohistochemistry and Sirius red staining. The ovarian protein and RNA were examined using Western blot and RT-PCR.ResultsIn DHEA-induced ovary in rat, fibrin and collagen had significantly higher levels, while the main fibrosis markers (TGF-β, CTGF, fibronectin, a-SMA) were obviously upregulated. SB431542 significantly reduced the expression of pro-fibrotic molecules (TGF-β, Smad3, Smad2, a-SMA) and increased anti-fibrotic factor MMP2.ConclusionTGF-βRI inhibitor (SB431542) inhibits the downstream signaling molecules of TGF-β and upregulates MMP2, which in turn prevent collagen deposition. Moreover, ovarian hyperfibrosis in DHEA-induced PCOS rat model could be improved by TGF-βRI inhibitor (SB431542) restraining the transcription of accelerating fibrosis genes and modulating EMT mediator.Electronic supplementary materialThe online version of this article (10.1186/s13048-017-0375-7) contains supplementary material, which is available to authorized users.

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Comment on “Inositols: from physiology to rational therapy in gynecological clinical practice”

Cited by 12 publications

References 5 publications

Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials

Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials

Soy, Soy Foods and Their Role in Vegetarian Diets

DHEA-induced ovarian hyperfibrosis is mediated by TGF-β signaling pathway

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