Comment on: “Managing Diabetic Foot Ulcers: Pharmacotherapy for Wound Healing”

Çolak, Bayram; Orhan, Atilla; Ece, Ilhan; Yormaz, Serdar; Yılmaz, Hüseyin; Şahi̇n, Mustafa

doi:10.1007/s40265-022-01673-8

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…Local tissue ischemia, characterized by reduced blood flow in the wound, can impede nutrient supply and hinder proper inflammation clearance, potentially leading to conditions such as venous ulcers, pressure sores, and chronic refractory wounds 37 , 38 . This disruption also affects the normal stages of wound repair and stands as a primary factor contributing to chronic wounds 39 .…”

Section: Discussionmentioning

confidence: 99%

Sulfated Chitosan Nanofibrous Scaffolds Seeded With Adipose Stem Cells Promote Ischemic Wound Healing in a Proangiogenic Strategy

Zhang,

Jiao,

Shen

et al. 2024

Cell Transplant

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Ischemic wounds are chronic wounds with poor blood supply that delays wound reconstruction. To accelerate wound healing and promote angiogenesis, adipose-derived stem cells (ADSCs) are ideal seed cells for stem cell–based therapies. Nevertheless, providing a favorable environment for cell proliferation and metabolism poses a substantial challenge. A highly sulfated heparin-like polysaccharide 2-N, 6-O-sulfated chitosan (26SCS)-doped poly(lactic-co-glycolic acid) scaffold (S-PLGA) can be used due to their biocompatibility, mechanical properties, and coagent 26SCS high affinity for growth factors. In this study, a nano-scaffold system, constructed from ADSCs seeded on electrospun fibers of modified PLGA, was designed to promote ischemic wound healing. The S-PLGA nanofiber membrane loaded with adipose stem cells ADSCs@S-PLGA was prepared by a co-culture in vitro, and the adhesion and compatibility of cells on the nano-scaffolds were explored. Scanning electron microscopy was used to observe the growth state and morphological changes of ADSCs after co-culture with PLGA electrospun fibers. The proliferation and apoptosis after co-culture were detected using a Cell Counting Kit-8 kit and flow cytometry, respectively. An ischemic wound model was then established, and we further studied the ability of ADSCs@S-PLGA to promote wound healing and angiogenesis. We successfully established ischemic wounds on the backs of rats and demonstrated that electrospun fibers combined with the biological effects of adipose stem cells effectively promoted wound healing and the growth of microvessels around the ischemic wounds. Phased research results can provide a theoretical and experimental basis for a new method for promoting clinical ischemic wound healing.

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Section: Discussionmentioning

confidence: 99%

Sulfated Chitosan Nanofibrous Scaffolds Seeded With Adipose Stem Cells Promote Ischemic Wound Healing in a Proangiogenic Strategy

Zhang,

Jiao,

Shen

et al. 2024

Cell Transplant

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Authors’ Reply to Colak et al.: “Managing Diabetic Foot Ulcers: Pharmacotherapy for Wound Healing”

Dixon

Edmonds

2022

Drugs

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We are sorry not to have referred in our review article [1] to the paper entitled "Comparison of the effects of cilostazol and aspirin on wound healing in patients with diabetic foot ulcer and peripheral artery disease" by Colak B, Orhan A, Ece I, Yormaz S, Yilmaz H, Sahin M [2]. In our section on Cilostazol, we stated "However, no comparison studies have been performed to identify the efficacy of cilostazol in diabetic ulcer healing to date."The explanation for the omission of the paper by Dr Bayram Colak et al is simply related to dates.

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Comment on: “Managing Diabetic Foot Ulcers: Pharmacotherapy for Wound Healing”

Cited by 2 publications

References 3 publications

Sulfated Chitosan Nanofibrous Scaffolds Seeded With Adipose Stem Cells Promote Ischemic Wound Healing in a Proangiogenic Strategy

Sulfated Chitosan Nanofibrous Scaffolds Seeded With Adipose Stem Cells Promote Ischemic Wound Healing in a Proangiogenic Strategy

Authors’ Reply to Colak et al.: “Managing Diabetic Foot Ulcers: Pharmacotherapy for Wound Healing”

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