Comment on `The detection rate of human papillomavirus in well‐differentiated squamous cell carcinoma and keratoacanthoma: is there new evidence for a viral pathogenesis of keratoacanthoma?' ‐ reply from authors

Abstract

Linked Articles: Taibjee et al. Br J Dermatol 2019; 181:1343–1345; Conforti et al. Br J Dermatol 2019; 181:1309–1311

Human Papillomavirus-Associated Giant Clear Cell Acanthoma and Squamous Cell Carcinoma: A Rare Case Report and Literature Review

“…Ramezani et al in 2020 conducted a meta-analysis specifically examining the association of β-HPV with SCC in immunosuppressed individuals, finding a high prevalence of β-HPVs in cutaneous SCC patients, which supports the hypothesis of β-HPV contributing to SCC development in those with compromised immune systems [65]. Nindl et al in 2007 and Galloway and Laimins in 2015 discussed the basic virology and clinical manifestations of HPV in relation to NMSC, highlighting the transforming properties of some HPV types and their potential co-factor role in SCC pathogenesis, especially in the context of UV-radiation and immune system interactions [23][24][25][26][27][28]32]. Waterboer et al in 2008 and Farzan et al in 2013 provided serological evidence linking beta and gamma HPV types to SCC risk, suggesting a specific association between these HPV genera and skin SCC [24,25].…”

“…Conforti [27] HPV can also be linked to keratoacanthoma Conforti [28] New concepts of cancerisation of HPV Parson [29] SCC can be linked to clear cell acanthoma D'Antonio [30] Clinical aspects of rare skin cancers Bandolin [31] HPV beta can be linked to tumorigenesis in the skin Galloway [32] Describes pathogenesis pathways of HPVs Balaji [33] Describes the role of HPV proteins in carcinogenesis Bouwes [2] Beta-HPV infection and cutaneous squamous cell carcinoma analogies…”