Comments on CSF κFLC assay evaluation in assessing intrathecal synthesis

Messaoudani, N.; Djidjik, Réda; Ghaffor, M

doi:10.1016/j.jneuroim.2013.11.008

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…These data add to the growing number of studies that have shown the utility of CSF FLC measurement in the diagnosis of MS (Duranti et al, 2013;Kaplan et al, 2013;Messaoudani et al, 2014;Presslauer et al, 2008;Senel et al, 2014), and that this assay can be more sensitive than OCB testing. In addition we show that a κ FLC concentration measurement alone is sufficient to provide this high level of sensitivity and specificity in suspected MS.…”

Section: Discussionmentioning

confidence: 63%

“…The majority of studies on FLC in the CSF have shown an increased sensitivity and specificity for MS diagnosis as compared to traditional OCB detection (Arneth and Birklein, 2009;Duranti et al, 2013;Kaplan et al, 2013;Presslauer et al, 2008;Villar et al, 2012). However, the specific results vary according to the assay methodology, using either ELISA or nephelometry (Senel et al, 2014) which may have different sensitivities, and with the use of an index measure of FLC (Duranti et al, 2013;Messaoudani et al, 2014;Presslauer et al, 2008), for example (CSF FLC/serum FLC)/(CSF albumin/serum albumin).…”

Section: Introductionmentioning

confidence: 99%

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High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis

Hassan-Smith

Durant

Tsentemeidou

et al. 2014

Journal of Neuroimmunology

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Cerebrospinal fluid (CSF) analysis is routinely used in the diagnostic work-up of multiple sclerosis (MS), by detecting CSF-specific oligoclonal bands (OCB). More recently, several studies have reported CSF free light chains (FLC) as an alternative. We show that absolute CSF κFLC concentrations were highly sensitive - more than OCB testing - and specific for clinically isolated syndrome, relapsing remitting and primary progressive MS. Measurement of κFLC alone was sufficient. Our results suggest that CSF κFLC levels measured by nephelometry, if validated in a larger series, are a preferred test to OCB analysis in the diagnostic work-up of patients suspected of having MS.

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Section: Discussionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis

Hassan-Smith

Durant

Tsentemeidou

et al. 2014

Journal of Neuroimmunology

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“…As evident from the information in Tables 2 and 3 in the appendix, it is apparent that the studies focused on different aspects of κ-FLC diagnostics. For instance, studies by Rosenstein et al [96], Ramsden [101], Messaoudani et al [107] and Martins et al [112] found that there was a higher concentration of κ-FLCs in patients with clinically validated multiple sclerosis. Overall, eight studies (Mead et al [49], Han et al [52], Nazarov et al [59], Kaplan et al [60], Vecchio et al [62], Annunziata et al [94], Saadeh et al [98], Arneth et al [111]) reported that free light chains could be effectively utilized in the diagnosis of multiple sclerosis.…”

Section: The Efficiency Of Kappa Free Light Chains In Diagnosing Mult...mentioning

confidence: 99%

The Use of Kappa Free Light Chains to Diagnose Multiple Sclerosis

Arneth

Kraus

2022

Medicina

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Background: The positive implications of using free light chains in diagnosing multiple sclerosis have increasingly gained considerable interest in medical research and the scientific community. It is often presumed that free light chains, particularly kappa and lambda free light chains, are of practical use and are associated with a higher probability of obtaining positive results compared to oligoclonal bands. The primary purpose of the current paper was to conduct a systematic review to assess the up-to-date methods for diagnosing multiple sclerosis using kappa and lambda free light chains. Method: An organized literature search was performed across four electronic sources, including Google Scholar, Web of Science, Embase, and MEDLINE. The sources analyzed in this systematic review and meta-analysis comprise randomized clinical trials, prospective cohort studies, retrospective studies, controlled clinical trials, and systematic reviews. Results: The review contains 116 reports that includes 1204 participants. The final selection includes a vast array of preexisting literature concerning the study topic: 35 randomized clinical trials, 21 prospective cohort studies, 19 retrospective studies, 22 controlled clinical trials, and 13 systematic reviews. Discussion: The incorporated literature sources provided integral insights into the benefits of free light chain diagnostics for multiple sclerosis. It was also evident that the use of free light chains in the diagnosis of clinically isolated syndrome (CIS) and multiple sclerosis is relatively fast and inexpensive in comparison to other conventional state-of-the-art diagnostic methods, e.g., using oligoclonal bands (OCBs).

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Comments on CSF κFLC assay evaluation in assessing intrathecal synthesis

Cited by 2 publications

References 7 publications

High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis

High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis

The Use of Kappa Free Light Chains to Diagnose Multiple Sclerosis

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