Comments to Article by Solah VA et al., Nutrients 2017, 9, 149

Vuksan, Vladimir; Jovanovski, Elena; Zurbau, Andreea; Komishon, Allison

doi:10.3390/nu9040398

Cited by 1 publication

(1 citation statement)

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“…Diabetes mellitus is a long-term metabolic condition characterized by insufficient insulin production, insulin action resistance, or both. It is associated with disturbances in carbohydrate, lipid and protein metabolism, which leads to hyperglycemia, hyperlipidemia, hyperinsulinemia and hypertension [ 1 ]. Diabetes is a leading contributor to conditions including blindness, limb amputation, renal failure, and cardiovascular disorders like heart attack and stroke [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of β-Caryophyllene on oxidative stress, glucose metabolism in the skeletal muscle of high fat diet and fructose-induced type-2 diabetic adult male rats

Mani

2023

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Skeletal muscle is where the majority of insulin-stimulated whole-body glucose elimination takes place under normal circumstances. A significant risk factor for metabolic diseases is high dietary fat consumption, which also increases stored fat mass. Natural solutions with anti-diabetic effectiveness and fewer side effects are becoming more popular as a result of the conventional pharmacological treatments' numerous negative side effects and high rates of secondary failure. Cannabis and a variety of culinary herbs and spices may include the naturally occurring sequiterpene β-caryophyllene. Among other things, it has antioxidant, anti-inflammatory, and anti-lipidemic properties. However, it is not yet known how β-caryophyllene affects the uptake and oxidation of glucose. Determining if β -caryophyllene has anti-diabetic properties in type-2 diabetes brought on by a high-fat diet was the objective of the current investigation. A sufficient dose of β-caryophyllene (200 mg/kg b.w.t., orally for 30 days) was given to type-2 diabetic rats fed a high-fat diet and given fructose as an inducer of diabetes to assess its anti-diabetic activity. The treatment of diabetes-induced rats with β -Caryophyllene restored the altered levels of blood glucose, serum insulin as well as the lipid parameters, oxidative stress markers, antioxidant enzymes. Our findings show that β-caryophyllene improves glycemia control by enhancing glucose absorption and oxidation in the skeletal muscle of type-2 diabetic rats. From the present findings, it is evident that β -caryophyllene can be used as an anti-diabetic drug.

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Section: Introductionmentioning

confidence: 99%