2013
DOI: 10.1016/j.jinf.2013.06.009
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Commercial MPT64-based tests for rapid identification of Mycobacterium tuberculosis complex: A meta-analysis

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Cited by 36 publications
(22 citation statements)
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“…Positive mycobacterial cultures were speciated as Mycobacterium tuberculosis complex or non-tuberculosis complex based on MPT64 rapid antigen test (Standard Diagnostics, Seoul, South Korea). (18) Selection of antibiotics, anti-malarials, and tuberculosis therapy was left to the admitting non-study physicians, as was the determination of additional investigations, such as malaria blood slides and cerebral spinal fluid studies. Decisions regarding transfer to intensive care unit (ICU) and initiation of mechanical ventilation or hemodialysis were likewise left to non-study physicians.…”
Section: Methodsmentioning
confidence: 99%
“…Positive mycobacterial cultures were speciated as Mycobacterium tuberculosis complex or non-tuberculosis complex based on MPT64 rapid antigen test (Standard Diagnostics, Seoul, South Korea). (18) Selection of antibiotics, anti-malarials, and tuberculosis therapy was left to the admitting non-study physicians, as was the determination of additional investigations, such as malaria blood slides and cerebral spinal fluid studies. Decisions regarding transfer to intensive care unit (ICU) and initiation of mechanical ventilation or hemodialysis were likewise left to non-study physicians.…”
Section: Methodsmentioning
confidence: 99%
“…Considering the length of a human scFv of ~ 4.5 nm [37] and the Fc-mediated homodimerisation of scFv-Fc fusions [34,61], sterical inhibition by the capture antibody is possible. The commercially available immunochromatographic assays for MPT64 antigen detection in Mtb cultures are sandwich assays with monoclonal antibodies [62]. The Capilia TB Test Kit [63] uses only one monoclonal antibody for a sandwich assay, indicating multimer detection.…”
Section: Discussionmentioning
confidence: 99%
“…Three commercial ICTs are available that detect MPT64, a secretory protein specific to the M. tuberculosis complex, in liquid and solid cultures. 18,27 These assays are simple to perform, have a turnaround time (TAT) of 30 minutes, and allow rapid identification of M. tuberculosis in positive liquid cultures such as MGIT. A meta-analysis of commercial ICTs reported a pooled sensitivity of 97% (95% CI, 96-97%) and a pooled specificity of 98% (95% CI, 98-99%).…”
Section: Mpt64 Immunochromatographic Testsmentioning
confidence: 99%