Committee II: Guidelines for cytologic sampling techniques of lung and mediastinal lymph nodes

Michael, C. W.; Faquin, William C.; Jing, Xin; Kaszuba, Frank J.; Kazakov, Jordan; Moon, Edmund K.; Toloza, Eric M.; Wu, Roseann I.; Moreira, André L.

doi:10.1002/dc.23975

Cited by 19 publications

(17 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The aspirate obtained can be stored in rosewell park memorial institute (RPMI) medium at 4°C for 5 days, which can be utilized to perform flow cytometry, karyotyping, and fluorescent in situ hybridization (FISH). [ 24 25 ] For mutation analysis and molecular testing, material from the cell block as well as scrape cytology from the slide can be used. [ 26 27 ] The common molecular testing recommended by the American Society of Clinical Oncology is EGFR, ALK, ROS, and BRAF.…”

Section: Discussionmentioning

confidence: 99%

Traveling with ROSE in EBUS-TBNA – Experience from a Tertiary Care Hospital in South India

Vasugi

Mathivanan

Rajendiran

et al. 2021

Journal of Cytology

View full text Add to dashboard Cite

Aims and Objectives: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has emerged as a precise modality for tissue sampling of mediastinal and hilar lesions adjacent to the proximal airway. This study aims to determine the diagnostic efficacy, sensitivity, and specificity of rapid-on site evaluation (ROSE) in EBUS-TBNA. Materials and Methods: This is a retrospective study that included 100 patients who underwent EBUS-TBNA of paratracheal and mediastinal lymph nodes in a tertiary care hospital in South India between March 2018 and March 2020. After the procedure, the diagnostic yield from the nodes sampled was transferred to slides that were stained with rapid hematoxylin and eosin (H and E), and then onsite evaluation was done. The tissue derived was also processed for histopathologic examination in all cases. ROSE was performed to assess sample adequacy and to arrive at a preliminary diagnosis. In patients suspected of tuberculosis, the sample was collected for GeneXpert evaluation as well. Results: Of the 100 cases studied, 51 were males and 49 were females. The age distribution was between 3 and 78 years. Forty-seven cases were diagnosed as granulomatous lymphadenitis, 13 as metastatic malignancies, 33 as reactive lymphadenitis, 3 as atypical cells, and 1 case was diagnosed as a cystic lesion. The diagnostic yield was not adequate for evaluation in three cases. Diagnostic yield was obtained in the first two passes where the lymph nodes were more than 2 cm in size. More diagnostic passes were required in lymph nodes less than 2 cm and those located between and adjacent to major vessels. The onsite diagnosis was correlated with the final histopathologic diagnosis. Conclusion: ROSE serves as a useful adjunct to reduce procedure time and enhance sample collection and triaging, and reduces the need for further invasive testing.

show abstract

Section: Discussionmentioning

confidence: 99%

Traveling with ROSE in EBUS-TBNA – Experience from a Tertiary Care Hospital in South India

Vasugi

Mathivanan

Rajendiran

et al. 2021

Journal of Cytology

View full text Add to dashboard Cite

show abstract

“…In lung cancer, surgical biopsies have been treated as the ideal specimens for postdiagnostic and theragnostic molecular testing. [1][2][3][4][5][6][7][8] Because cytopathology offers a unique opportunity for a direct role in the procurement of specimens through rapid onsite evaluation (ROSE), cytopathologists have been directly and dramatically Cancer Cytopathology September 2020 affected by this apparent fall from ideality. The specimen procured with the help of a cytopathologist has been overshadowed by surgical specimens.…”

Section: A Fablementioning

confidence: 99%

Lung cancer and molecular testing in small biopsies versus cytology: The Logics of Worlds

Rossi

Wiles

Vecchione

2020

Cancer Cytopathology

View full text Add to dashboard Cite

The 8th Annual National Molecular Cytopathology Meeting, held in Naples, Italy, on December 2 to 3, 2019, addressed updates in diagnostic cytopathology and molecular classifications and specifically focused on lung cancer biomarker testing in cytology samples. Lung cancer continues to be the most commonly diagnosed noncutaneous malignancy in the world. In the majority of patients, lung cancers are frequently identified when they cannot be surgically accessed, and this leads to the use of cytology for a diagnosis and theragnostic testing. The meeting was an international forum for discussing new roles and updates for cytopathology in molecular testing as the basis for provoking new trends and novel approaches. The relevant literature is referenced. The significance of these updates for the practice of pathology in general is discussed.

show abstract

“…In contrast to the 1999 version, the updates now correspond to a set of four separate articles aimed at helping the cytopathologists navigate the new landscape of pulmonary pathology! These new guidelines include detailed recommendations on the indications for the procedures, 2 explanations on the new sampling methods, adequacy criteria and its implications for the diagnosis, 3 as well as specific recommendations for the standardization of diagnostic nomenclature (Table 1) 4 and the utilization of ancillary techniques 5 …”

Section: 20164 Category Criteria Category Criteriamentioning

confidence: 99%

Evolution of guidelines for respiratory cytology by the Papanicolaou Society of Cytopathology

Moreira

2020

Diagnostic Cytopathology

View full text Add to dashboard Cite

Cytology serves a fundamental role in the evaluation of the lower respiratory tract. Cytological specimens are often the first diagnostic attempt for the evaluation of radiographic alterations. The categorization of the pathological process as infectious, inflammatory or neoplastic is critical in guiding further clinical management of the affected patient. Therefore it is imperative that cytopathologists use a standardized approach to sample handling and reporting in order to establish clear communication with the treating physician. The Papanicolaou Society of cytopathology has been an active leader in this field and has proposed several guidelines for sampling, handling, and reporting of lower respiratory tract cytology. These guidelines have been updated to incorporate new emerging concepts and technologies in the field. Respiratory medicine is a fast growing area with constant new challenges, thus requiring an ever demanding adaptation from cytopathologists and cytology specific guidelines.

show abstract

Committee II: Guidelines for cytologic sampling techniques of lung and mediastinal lymph nodes

Cited by 19 publications

References 78 publications

Traveling with ROSE in EBUS-TBNA – Experience from a Tertiary Care Hospital in South India

Traveling with ROSE in EBUS-TBNA – Experience from a Tertiary Care Hospital in South India

Lung cancer and molecular testing in small biopsies versus cytology: The Logics of Worlds

Evolution of guidelines for respiratory cytology by the Papanicolaou Society of Cytopathology

Contact Info

Product

Resources

About