Common Genetic Variation In IGFBP7 Is Associated With Cortical Brain Development In Preterm Infants

Abstract

In a cohort of 185 infants born preterm we used linked MR imaging, genomic and neurodevelopmental data, to identify a significant association between common genetic variation in the IGFBP7 gene and cortical grey matter volumes as assessed at term-corrected age (p = 0.0057), as well as motor outcomes as assessed at 18-24 months of age (p = 0.044).