Common inflammatory and infectious conditions of the eyelid

Gordon, Abigail A.; Danek, Dagmara; Phelps, Paul O.

doi:10.1016/j.disamonth.2020.101042

Cited by 8 publications

(5 citation statements)

References 15 publications

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“…24 Moreover, the nonophthalmic literature by and large correctly describes the fundamental difference between a hordeolum and chalazion and designates both entities as preseptal in origin. [25][26][27] Cognitive bias may also play a role in the determination to prescribe an antibiotic. Research has demonstrated that physician overconfidence, the anchoring effect, and information or availability bias may all be associated with diagnostic inaccuracies.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of Care and Antibiotic Use for Chalazia and Hordeola

Alsoudi

Ton²,

Ashraf³

et al. 2021

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Objectives: To evaluate whether use of an antibiotic improves the efficacy of care for a chalazion or hordeolum. Methods: A cross-sectional retrospective review was performed. All patients treated for a newly diagnosed chalazion or hordeolum at the University of California, San Francisco from 2012 to 2018 were identified. Patients were excluded when clinical notes were inaccessible or there was inadequate documentation of treatment modality or outcome. Patient demographics, setting of initial presentation, treatment modalities, antibiotic use, and outcomes were analyzed. Results: A total of 2,712 patients met inclusion criteria. Management with an antibiotic was observed in 36.5% of patients. An antibiotic was 1.53 times (95% confidence interval [CI], 1.06-2.22, P¼0.025) more likely to be prescribed in emergency or acute care setting for a chalazion. Older age was associated with a higher risk of receiving an antibiotic for a hordeolum (adjusted RR 1.07 per decade, 95% CI, 1.05-1.11, P,0.001). The addition of an antibiotic to conservative measures for a chalazion (adjusted RR, 0.97, 95% CI, 0.89-1.04, P¼0.393) or hordeolum (adjusted RR, 0.99, 95% CI, 0.96-1.02, P¼0.489) was not associated with an increased likelihood of treatment success. Conclusion: Although frequently prescribed, an antibiotic is unlikely to improve the resolution of a chalazion or hordeolum.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Efficacy of Care and Antibiotic Use for Chalazia and Hordeola

Alsoudi

Ton²,

Ashraf³

et al. 2021

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

View full text Add to dashboard Cite

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“…Chalazia generally presents on the upper eyelid due to the increased concentration of meibomian glands on the tarsal plate of the upper lid. Like this patient, those presenting with chalazia may complain of nonspecific symptoms such as discomfort or a foreign body sensation [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Lens Material of the Eyelid Masquerading as Phakomatous Choristoma After Cataract Surgery

Inouye¹,

Ahmed²,

Cho³

et al. 2023

Cureus

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Cataract surgery is the most commonly performed surgery worldwide. While retained lens fragments after cataract surgery are common, to our knowledge, there is no prior case report of the lens material being deposited outside of the eye. Here, we present a case of an elderly patient with an upper eyelid lesion containing a fragment of the basement membrane and proteinaceous lens-like material, initially mistaken as phakomatous choristoma. Phakomatous choristoma is a type of benign congenital tumor consisting of lens tissue, which is thought to be secondary to aberrant migration during lens formation. Upon further review, it was later confirmed to be postoperative capsular material embedded into the eyelid.

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“…If the Zeis gland is affected, a smaller and more superficial swelling occurs near the eyelash base. Approximately four days post-hordeolum onset, the course of the condition depends on individual resistance, with Staphylococcus aureus reinfections within the lesion potentially spreading or remaining localized [ 91 , 92 ]. Worsened inflammation may lead to eyelid cellulitis development, or an abscess may form, culminating in a firm, white nodule.…”

Section: Inflammation In Ophthalmology Diseasesmentioning

confidence: 99%

Next-generation nanomaterials: advancing ocular anti-inflammatory drug therapy

Wei,

Mu,

Tang

et al. 2023

J Nanobiotechnol

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Ophthalmic inflammatory diseases, including conjunctivitis, keratitis, uveitis, scleritis, and related conditions, pose considerable challenges to effective management and treatment. This review article investigates the potential of advanced nanomaterials in revolutionizing ocular anti-inflammatory drug interventions. By conducting an exhaustive analysis of recent advancements and assessing the potential benefits and limitations, this review aims to identify promising avenues for future research and clinical applications. The review commences with a detailed exploration of various nanomaterial categories, such as liposomes, dendrimers, nanoparticles (NPs), and hydrogels, emphasizing their unique properties and capabilities for accurate drug delivery. Subsequently, we explore the etiology and pathophysiology of ophthalmic inflammatory disorders, highlighting the urgent necessity for innovative therapeutic strategies and examining recent preclinical and clinical investigations employing nanomaterial-based drug delivery systems. We discuss the advantages of these cutting-edge systems, such as biocompatibility, bioavailability, controlled release, and targeted delivery, alongside potential challenges, which encompass immunogenicity, toxicity, and regulatory hurdles. Furthermore, we emphasize the significance of interdisciplinary collaborations among material scientists, pharmacologists, and clinicians in expediting the translation of these breakthroughs from laboratory environments to clinical practice. In summary, this review accentuates the remarkable potential of advanced nanomaterials in redefining ocular anti-inflammatory drug therapy. We fervently support continued research and development in this rapidly evolving field to overcome existing barriers and improve patient outcomes for ophthalmic inflammatory disorders. Graphical Abstract

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Common inflammatory and infectious conditions of the eyelid

Cited by 8 publications

References 15 publications

Efficacy of Care and Antibiotic Use for Chalazia and Hordeola

Efficacy of Care and Antibiotic Use for Chalazia and Hordeola

Lens Material of the Eyelid Masquerading as Phakomatous Choristoma After Cataract Surgery

Next-generation nanomaterials: advancing ocular anti-inflammatory drug therapy

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