Common pathogenic mechanisms and pathways in the development of COPD and lung cancer

Yang, Ian A.; Relan, Vandana; Wright, Casey M.; Davidson, M.; Sriram, Krishna; Francis, Santiyagu M. Savarimuthu; Clarke, Belinda; Duhig, Edwina; Bowman, Rayleen V.; Fong, Kwun M.

doi:10.1517/14728222.2011.555400

Cited by 80 publications

(70 citation statements)

References 128 publications

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“…Pulmonary chronic inflammation and lung cancer are closely correlated. Many common features coexist in both diseases, and the potential shared biological mechanisms are inflammation, EMT and others, especially the inflammatory factor (26,27). Recent reports demonstrated that tobacco smoke promoted lung tumorigenesis by triggering inflammatory pathways (28).…”

Section: Flavonoid Components In Scutellaria Baicalensis Inhibit Nicomentioning

confidence: 99%

Flavonoid components in Scutellaria baicalensis inhibit nicotine-induced proliferation, metastasis and lung cancer-associated inflammation in vitro

Gong

Liu

et al. 2014

International Journal of Oncology

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Abstract. The objective of the present study was to investigate the therapeutic efficacy of flavonoid components in Scutellaria baicalensis on proliferation, metastasis and lung cancer-associated inflammation during nicotine induction in the A549 and H1299 lung cancer cell lines. After experimental period, augmentation of proliferation was observed, accompanied by marked decrease in apoptotic cells in nicotine-induced lung cancer cells; additionally, nicotine-exposed cells exhibited increased invasive and migratory abilities based on invasion and wound-healing assay. Flavones in Scutellaria, baicalin, baicalein and wogonin significantly counteracted the above deleterious changes. Moreover, assessment of tumor apoptotic and metastatic factors on mRNA levels by quantitative PCR and protein levels by western blotting revealed that these phytochemical treatments effectively negated nicotine-induced upregulated expression of bcl-2, bcl-2/bax ratio, caspase-3, matrix metalloproteinase (MMP)-2 and MMP-9 as well as downregulated expression of bax. Further analysis of inflammatory markers such as tumor necrosis factor (TNF)-α and interleukin (IL)-6 in cell culture supernatant and mRNA and protein expression of nuclear transcription factor-kappaB (NF-κB) and I kappa B-alpha (IκB-α) was carried out to substantiate the anti-inflammatory effect of flavones in Scutellaria in nicotine-exposed lung cancer cells. The therapeutic effects observed in the present study are attributed to the potent potential against proliferation, metastasis and inflammatory microenvironment by flavonoid components in Scutellaria in nicotine-induced lung cancer cells.

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Section: Flavonoid Components In Scutellaria Baicalensis Inhibit Nicomentioning

confidence: 99%

Flavonoid components in Scutellaria baicalensis inhibit nicotine-induced proliferation, metastasis and lung cancer-associated inflammation in vitro

Gong

Liu

et al. 2014

International Journal of Oncology

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“…COPD involves chronic inflammation of the respiratory tract, particularly of the small airways, and is manifested by the accumulation of macrophages, CD4+ and CD8+ T-cells, dendritic cells, and neutrophils [66]. It has been suggested that chronic inflammation in the lower respiratory tract can induce carcinogenesis [67][68][69], and that inflammatory mediators in the microenvironment promote bronchioalveolar stem cells to induce proneoplastic mutations, proliferation, resistance to apoptosis, angiogenesis, invasion, metastasis and secretion of immunosuppressive factors ( fig. 1) [70,71].…”

Section: Review: Early Detection Of Copd In Lung Cancer Y Sekine Et Almentioning

confidence: 99%

Early detection of COPD is important for lung cancer surveillance

Sekine¹,

Katsura²,

Koh³

et al. 2011

Eur Respir J

125

101

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It is well known that chronic obstructive pulmonary disease (COPD) is a significant risk factor for lung cancer. Approximately 1% of COPD patients develop lung cancer every year, which may be associated with genetic susceptibility to cigarette smoke. Chronic inflammation caused by toxic gases can induce COPD and lung cancer. Inflammatory mediators may promote the growth of bronchioalveolar stem cells, and activation of nuclear factor-kB and signal transducer and activator of transcription 3 play crucial roles in the development of lung cancer from COPD.Low-dose computed tomography (LDCT) is an effective procedure for the early detection of lung cancer in high-risk patients. However, determining which patients should be screened for lung cancer in a primary care setting is difficult. In this article, we review the epidemiology and aetiology of lung cancer associated with COPD, verify the efficacy of lung cancer screening by LDCT, and discuss the importance of early detection of COPD for lung cancer surveillance.We propose that, for the prevention of both diseases, COPD screening in smokers should be initiated as early as possible, so they can stop smoking and so that candidates for an efficient lung cancer screening programme can be identified.

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“…There is mounting evidence that COPD and lung cancer are related by much more than smoking or aero-pollutant exposure alone [54][55][56][57][58][59][60][61][62][63]. Epidemiological studies dating back 30 years have suggested that the propensity to lung cancer is substantially increased in those with COPD, even after correction for smoking exposure [55].…”

Section: Statins In Lung Cancermentioning

confidence: 99%

“…Update on the potential role of statins in COPD & its co-morbidities Review www.expert-reviews.com inflammation (FIGURE 1), are relevant to both diseases implicating inflammation in their pathogenesis [60][61][62][63][64] and providing a potential target for chemopreventive treatment [5]. Numerous prospective studies have reported associations between elevated CRP (systemic inflammation) and mortality from cancers of the lung, breast, prostate and colon [36][37][38][65][66][67].…”

Section: Aecopd Hospitalisationmentioning

confidence: 99%

Update on the potential role of statins in chronic obstructive pulmonary disease and its co-morbidities

Young¹,

Hopkins

2013

Expert Review of Respiratory Medicine

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Chronic obstructive pulmonary disease (COPD) is soon to become the third leading cause of death in developed countries. COPD is increasingly considered a multisystem disease characterized by both pulmonary and systemic inflammation. Over the last 5 years, there have been a growing number of studies showing that the cholesterol-lowering drugs statins (HMG-CoA reductase inhibitors) have a beneficial effect in patients with COPD. While statins are known to have a number of pharmacological effects (pleiotropy) that could explain these benefits, it is currently not clear which effects are most relevant in COPD. This article reviews the most recently published studies of statin therapy in patients with COPD, focusing on the important COPD co-morbidities of the pulmonary system (infective exacerbations, pneumonia, influenza and lung cancer) and cardiovascular system (acute coronary syndrome, endothelial dysfunction and pulmonary hypertension). While we await the results of randomized controlled trials, there continues to be consistent (albeit indirect) evidence from observational studies suggesting statins are beneficial for patients with COPD, conferring important pharmacological effects on inflammation not conferred by current inhaler-based therapies.

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Common pathogenic mechanisms and pathways in the development of COPD and lung cancer

Abstract: Strategies to study genomics, epigenomics and gene-environment interaction will yield greater insight into the shared pathogenesis of lung cancer and COPD, leading to new diagnostic and therapeutic modalities.

Cited by 80 publications

References 128 publications

Flavonoid components in Scutellaria baicalensis inhibit nicotine-induced proliferation, metastasis and lung cancer-associated inflammation in vitro

Flavonoid components in Scutellaria baicalensis inhibit nicotine-induced proliferation, metastasis and lung cancer-associated inflammation in vitro

Early detection of COPD is important for lung cancer surveillance

Update on the potential role of statins in chronic obstructive pulmonary disease and its co-morbidities

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