Common single nucleotide polymorphism of hypoxia‐inducible factor‐1α and its impact on the clinicopathological features of esophageal squamous cell carcinoma

Ling, Ting; Shi, Rui; Zhang, Guo Xin; Zhu, Hong; Yu, Lian Zhen; Ding, Xueying

doi:10.1111/j.1443-9573.2005.00223.x

Cited by 45 publications

(34 citation statements)

References 15 publications

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“…In this study, the C1772T and G1790A mutation rates in pancreatic cancer were 10% (1/10) and 0%, respectively, for pancreatic cancer and 6.3% (1/16) and 6.3% (1/16), respectively, for gallbladder cancer (all heteromutation-type). These results, together with those of previous reports (2,(8)(9)(10)(11) show a low SNP rate for all cancers, except renal cancer, suggesting the lack of an association between SNPs and carcinogenesis.…”

Section: Discussionsupporting

confidence: 86%

“…However, type 2 diabetes mellitus is a risk factor for pancreatic cancer, which suggests an association between the development of pancreatic cancer and the SNPs of HIF-1α. There have been studies on an association between carcinogenesis and HIF-1α SNPs in cancer in various organs (2,(8)(9)(10)(11). The C1772T and G1790A mutation rates were reported to be 18 and 11%, respectively, in patients with head or neck cancer, and 11 and 8%, respectively, in healthy subjects, with no statistically significant differences between the 2 groups (2).…”

Section: Discussionmentioning

confidence: 99%

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Hypoxia-inducible factor-1α expression and gemcitabine chemotherapy for pancreatic cancer

et al. 2011

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Abstract. The normal pancreas has an abundant blood flow, in contrast to pancreatic cancer, which is a hypovascular tumor. During hypoxia under a hypovascular environment, the transcription factor hypoxia-inducible factor-1α (HIF-1α) is activated. High HIF-1α expression reduces sensitivity to gemcitabine (GEM) which is used as a treatment for pancreatic cancer. The objective of this study was to clarify HIF-1α expression in pancreatic cancer and the association of its effects to GEM treatment. We used the human pancreatic ductal carcinoma cell lines AsPC-1 and BxPC-3 to evaluate cell proliferation, HIF-1α protein expression and sensitivity to GEM in a hypoxic environment of 1% O 2 in 48 pancreatic cancer patients who received adjuvant GEM treatment after pancreatectomy. We divided the patients according to HIF-1α expression and the presence of single nucleotide polymorphisms, and we based our evaluation on the adverse events associated with GEM chemotherapy and patient outcome. The hypoxic environment promoted cell proliferation, induced HIF-1α expression and increased GEM resistance, especially in AsPC-1 cells, which included a mutant homozygote for HIF-1α(C1772T). There were no significant differences between the HIF-1α(-) and HIF-1α(+) groups in either adverse events or patient outcomes. HIF-1α enhanced neo-microvascularity in a hypoxic environment and increased drug resistance. The period until recurrence was shorter in the patients with a strong HIF-1α expression, than that in those with a weak HIF-1α expression.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Hypoxia-inducible factor-1α expression and gemcitabine chemotherapy for pancreatic cancer

et al. 2011

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“…In the present study, the distribution of C1772T genotypes in control groups was approximately similar to those reported in previous studies (Clifford et al, 2001;Tanimoto et al, 2003;Ling et al, 2005). We found no evidence of a relationship between clinicopathological characteristics and C1772T polymorphism in endometrial cancer patients.…”

Section: 10393 the Polymorphism Of Hypoxia-inducible Factor-1a Gene supporting

confidence: 72%

The Polymorphism of Hypoxia-inducible Factor-1a Gene in Endometrial Cancer

Kafshdooz¹,

Tabrizi²,

Mohaddes³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Endometral carcinoma is the most common malignant tumor of the female genital tract and the fourth most common cancer in women after breast, colorectal and lung cancers Hypoxia-inducible factor -1 (HIF-1) is a key transcription factor that regulates cellular response to hypoxia HIF-1 plays important roles in the development and progression of cancer through activation of various genes that are involved in crucial aspects of cancer biology, including angiogenesis, energy metabolism, vasomotor function, erythropoiesis, and cell survival. In this study, we aimed to investigate the association between HIF-1 1772 C/T polymorphisms and endometrial cancer. Materials and Methods: 75 patients with endometrial carcinoma and 75 patients whose underwent hysterectomy for non tumoral indication selected for evaluation of HIF-1 1772 C/T polymorphisms by PCR-RFLP and sequencing. Results: For the 1772 C/T polymorphism, the analysis showed that the T allele and genotype TT were significantly associated with endometrial cancer risk. Conclusions: Our results suggest that the C1772T polymorphism of the HIF-1a may be associated with endometrial cancers.

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“…In accordance with the inclusion criteria, 8 case-control studies (Kuwai et al, 2004;Ling et al, 2005;Fransen et al, 2006;Li et al, 2009;Hsiao et al, 2010;Knechtel et al, 2010;Kang et al, 2011;Wang et al, 2011) were included in this meta-analysis and 91 articles were excluded. The flow chart of the study selection process is shown in Figure 1.…”

Section: Baseline Characteristics Of Included Studiesmentioning

confidence: 99%

“…However, the exact mechanism of these polymorphisms in the development of digestive cancer is not clearly understood (Huang et al, 2012). Recent evidence has suggested that HIF-1α gene polymorphisms may be associated with increased digestive cancer risk (Ling et al, 2005;Fransen et al, 2006;Li et al, 2009;Hsiao et al, 2010;Kang et al, 2011;Wang et al, 2011); however, individually published results are inconclusive (Kuwai et al, 2004;Knechtel et al, 2010). Therefore, we attempt to perform a meta-analysis of all eligible case-control studies to provide insights into these associations, which may promote our understanding of the exact role of the HIF-1α gene in the development of carcinogenesis in the digestive organs.…”

Section: Introductionmentioning

confidence: 99%

Common polymorphisms in the HIF-1αgene confer susceptibility to digestive cancer: a meta-analysis

Zou

Liu

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Recent evidence suggests that common functional polymorphisms in the hypoxia inducible factor-1α (HIF-1α) gene may play an important role in the development and progression of digestive cancer, but individually published results are inconclusive. Our metaanalysis is aimed to derive a more precise estimation of the relationships between HIF-1α gene polymorphisms and digestive cancer risk. An extensive literature search for relevant studies was conducted on Pubmed, Embase, Web of Science, Cochrane Library, and CBM databases from their inception through May 1, 2013. This meta-analysis was performed using the STATA 12.0 software. The crude odds ratios (OR) with 95% confidence interval (CI) were calculated. Eight case-control studies were included with a total of 1276 digestive cancer patients and 3392 healthy controls. Our meta-analysis revealed that the A variant of HIF-1α G1790A polymorphism might be associated with increased risk of colorectal, esophageal, gastric, and liver cancers, especially among Asian populations. However, no statistically significant associations were found between HIF-1α C1772T polymorphism and susceptibility to digestive cancer. No publication bias was detected in this metaanalysis. The current meta-analysis suggests that the HIF-1α G1790A polymorphism may increase the risk of colorectal, esophageal, gastric, and liver cancers, especially among Asian populations.

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Common single nucleotide polymorphism of hypoxia‐inducible factor‐1α and its impact on the clinicopathological features of esophageal squamous cell carcinoma

Abstract: Although there is no significant difference of genotype distribution between ESCC patients and healthy controls, genotype C/T is associated with larger tumor and higher rate of lymph node metastasis.

Cited by 45 publications

References 15 publications

Hypoxia-inducible factor-1α expression and gemcitabine chemotherapy for pancreatic cancer

Hypoxia-inducible factor-1α expression and gemcitabine chemotherapy for pancreatic cancer

The Polymorphism of Hypoxia-inducible Factor-1a Gene in Endometrial Cancer

Common polymorphisms in the HIF-1αgene confer susceptibility to digestive cancer: a meta-analysis

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