Common ß-adrenergic receptor polymorphisms are not associated with risk of sudden cardiac death in patients with coronary artery disease

Tseng, Zian H.; Aouizerat, Bradley E.; Pawlikowska, Ludmila; Vittinghoff, Eric; Lin, Feng; Whiteman, Dean; Poon, Annie; Herrington, David M.; Howard, Timothy D.; Varosy, Paul D.; Hulley, Stephen B.; Malloy, Mary J.; Kane, John P.; Kwok, Pui‐Yan; Olgin, Jeffrey E.

doi:10.1016/j.hrthm.2008.03.016

Cited by 19 publications

(31 citation statements)

References 29 publications

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“…Case-control studies reported no association between this polymorphism and the above-mentioned phenotypic outcomes [46,47]. Although these case-control studies have relatively large sample sizes (495–5393), they may have been confounded by unmeasured factors.…”

Section: Adrb2: Arg16gly; 285a >G (Rs1042713)mentioning

confidence: 99%

“…The polymorphism encoding the Gln27Glu change was not associated with the increased risk of sudden cardiac death and ventricular arrhythmias in patients with coronary artery disease [46], nor is it associated with the risk of MI or ischemic stroke in patients who were pharmacologically treated for hypertension [47]. The polymorphism has also been studied in heart failure.…”

Section: Adrb2: Gln27glu; 318c >G (Rs1042714)mentioning

confidence: 99%

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Very important pharmacogene summary ADRB2

Litonjua

Gong²,

Duan

et al. 2010

Pharmacogenetics and Genomics

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Section: Adrb2: Arg16gly; 285a >G (Rs1042713)mentioning

confidence: 99%

Section: Adrb2: Gln27glu; 318c >G (Rs1042714)mentioning

confidence: 99%

Very important pharmacogene summary ADRB2

Litonjua

Gong²,

Duan

et al. 2010

Pharmacogenetics and Genomics

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“…Specifically, several prior study populations in which no associations or weak associations between ADRB2 and sudden cardiac arrest were identified were recruited from populations that were already in clinical care 17 or were healthcare professionals. 15 By contrast, the Cardiovascular Health Study, where a strong positive association was observed, was a population-based sample.…”

Section: Discussionmentioning

confidence: 99%

“…14 We note, however, that these prior studies included other population differences, including prevalence of known coronary artery disease, and measurement differences, including sudden cardiac arrest identification, that may also explain the inconsistent findings. 17 …”

Section: Discussionmentioning

confidence: 99%

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In the Wrong Place with the Wrong SNP

et al. 2016

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Background Sudden cardiac arrest has been linked independently both to stressful neighborhood conditions and to polymorphisms in the ADRB2 gene. The ADRB2 gene mediates sympathetic activation in response to stress. Therefore, if neighborhood conditions cause cardiac arrest through the stress pathway, the ADRB2 variant may modify the association between neighborhood conditions such as socioeconomic deprivation and incidence of cardiac arrest. Methods The Cardiac Arrest Blood Study Repository is a population-based repository of specimens and other data from adult cardiac arrest patients residing in King County, Washington. Cases (n = 1,539) were 25- to 100-year-old individuals of European descent who experienced out-of-hospital cardiac arrest from 1988 to 2004. Interactions between neighborhood conditions and the ADRB2 genotype on cardiac arrest risk were assessed in a case-only study design. Gene–environment independence was assessed in blood samples obtained from King County residents initially contacted by random-digit dialing. Results Fewer than 4% of study subjects resided in socioeconomically deprived neighborhoods. Nonetheless, the case-only analysis indicated the presence of supra-multiplicative interaction of socioeconomic deprivation and the homozygous Gln27Glu variant [Case-only odds ratio (OR): 1.8 (95% confidence interval [CI]: 1.0, 2.9)]. Interactions between population density and the homozygous Gln27Glu variant were weaker [Case-only OR: 1.2, (95% CI: 0.97, 1.5)]. Conclusions Findings support a supra-multiplicative interaction between the Gln27Glu ADRB2 variant and socioeconomic deprivation among individuals of European descent. This result is consistent with the hypothesis that the elevation in cardiac arrest risk associated with socioeconomic deprivation operates through the stress pathway.

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