Common Strategy for Adult and Pediatric Medulloblastoma: A Multicenter Series of 253 Adults

Padovani, Laëtitia; Sunyach, Marie‐Pierre; Pérol, David; Mercier, Cédric; Alapetite, Claire; Haie-Méder, Christine; Hoffstetter, S.; Muracciole, Xavier; Kerr, Christine; Wagner, Jean-Philippe; Lagrange, Jean‐Léon; Maire, Jean-Philippe; Cowen, D.; Frappaz, Didier; Carrié, C.

doi:10.1016/j.ijrobp.2006.12.030

Cited by 139 publications

(151 citation statements)

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“…3 Recently reported overall survival rates for both children and adults are in the 60th and 70th percentiles, a significant increase from the 29% 5-year overall survival rate reported in earlier periods. 2,[4][5][6][7][8][9][10] Studies have demonstrated that medulloblastomas in adults and children are histologically and genetically different diseases. [11][12][13] Because of obvious differences in expected survival between adults and children in the general population (with adults more likely to die than children), comparing the survival profiles of children and adults with brain tumors requires a particular approach, namely, the use of relative survival.…”

Section: Introductionmentioning

confidence: 99%

Relative survival of childhood and adult medulloblastomas and primitive neuroectodermal tumors (PNETs)

Smoll

2011

Cancer

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BACKGROUND: Medulloblastomas are 1 of the most common brain tumors in children but can affect individuals of all ages. For this report, the author investigated the impact of medulloblastomas/primitive neuroectodermal tumors (PNETs) on the US population with a focus on age differences. METHODS: Data from the Surveillance, Epidemiology, and End Results (SEER) database were used to describe cumulative relative survival (CRS) using crude, period, and longitudinal period approaches for patients diagnosed with all medulloblastoma subtypes and PNETs. CRS estimates were obtained using SEER expected mortality data and the Ederer II method for expected survival estimation. These data were applied to the construction of rational follow-up scheduling protocols. RESULTS: The 5-year period CRS for all patients who were followed between 2001 and 2006 was 69%. Adults had a worse overall prognosis, but this difference in excess hazard rates appeared only after 4 years of follow-up. Furthermore, the 5-year and 10-year CRS has improved a minimum of 11% in children, adolescents, and adults over the past 25 years. CONCLUSIONS: The survival difference between children, adolescents, and adults with medulloblastomas and PNETs depended on the length of follow-up, which was described in this report as an age-by-follow-up interaction and observed as a ''fork'' on Kaplan-Meier curves. Differences in survival between children and adults emerged only 4 years after diagnosis, and adults fared worse. There has been significant improvement in survival from medulloblastomas/PNETs since the late 1970s and early 1980s. Cancer 2012;118:1313-

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Section: Introductionmentioning

confidence: 99%

Relative survival of childhood and adult medulloblastomas and primitive neuroectodermal tumors (PNETs)

Smoll

2011

Cancer

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“…In the study by Padovani et al which had the greatest number of patients, metastasis, postoperative performance, central nervous system involvement were determined as factors that are important for prognosis; [19] other prognostic factors were determined to be M stage and duration before initiation of postoperative RT in the study by Abacıoğlu et al [21] location of tumor in the study by Menon et al [30] type of surgery, RT and histology in the study by Lai et al [31] gender in the study by Riffaud et al [32] performed with gamma knife. There were less side effects, and higher doses could be attained by this way.…”

Section: Discussionmentioning

confidence: 99%

“…Five and 10 year overall survival rates were reported as 58.5% and 41%, respectively. [19] Adjuvant RT should be initiated within 28-30 days following surgery, and the treatment should be continued without any interruptions if possible. In International Society of Paediatric Oncology (SIOP) PNET-3 study, it was stated that interruptions during treatment affected overall and disease-free survival adversely.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of Surgery and Craniospinal Radiotherapy for Adult Patients with Medulloblastoma

Güzelöz¹

2017

TJ Oncol

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OBJECTIVEThe aim of the present study was to evaluate treatment outcomes for adult patients with medulloblastoma who received craniospinal irradiation following surgery at Dokuz Eylül University Radiation Oncology Department. METHODSTwelve patients were evaluated retrospectively. Median age was 31 years (range: 18-55 years). According to Chang staging system, 3 (25%) of the patients were T1, 2 (17%) were T2, 5 (42%) were T3, and 1 (8%) was T4; 1 patient could not be staged due to inadequate preoperative imaging. Tumor location, stage, presence of residual disease, duration between surgery and radiotherapy (RT), age, and sex were evaluated as prognostic factors. Statistical analyses were conducted using Kaplan-Meier method and SPSS for Windows, Version 15.0 (SPSS Inc., Chicago, IL, USA). RESULTSMedian dose was 36 Gy (range: 32-44 Gy) to craniospinal field and 54 Gy (range: 50-56 Gy) to primary tumor location. Median follow-up time was 62 months (range: 4-212 months). Five-, 10-, and 15-year overall survival rates were 79%, 63%, and 63%, and 5-, 10-and 15-year progression-free survival rates were 63%, 63%, and 63%, respectively. No statistically significant prognostic factor was found for survival rate. Three (25%) patients developed serious hematological toxicity during RT course. No grade 3 or 4 late side effect was observed. CONCLUSIONDespite the limited number of cases, results are consistent with the literature. Evaluation of features of this rare disease requires studies with larger number of.

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“…Radiotherapy to the craniospinal axis at a dose of 36 Gy for 4 weeks followed by a boost to the posterior fossa at a dose of 54 Gy for 6 weeks has been adopted as standard practice. In a French multicenter study, a radiotherapy dose of <50 Gy to the posterior fossa was found to be a poor prognostic factor for MB patients (11). The extent of resection and the interval between surgery and radiotherapy were also prognostic factors of MB (12,13).…”

Section: A B C Dmentioning

confidence: 95%

Medulloblastoma with soft-tissue and skeletal metastases in an adult: A case report

et al. 2015

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Abstract. Medulloblastoma (MB) is a highly malignant primary brain tumor, which occurs in the cerebellum or posterior cranial fossa. MB is most commonly identified in children <10 years of age. The disease is rare in adults, affecting patients aged between 30 and 50 years of age, with an incidence of 0.5 cases per 1,000,000 individuals. Extraneural metastases are reported in 7-10% of cases, most commonly involving the bones and more rarely involving the lymph nodes, visceral organs and bone marrow. The current study presents the case of a 36-year-old male who underwent a gross total resection followed by radiation therapy to the craniospinal axis for the treatment of MB. The patient subsequently developed widespread metastasis, which involved the soft tissue of the occipital bone. Subsequently, the patient was administered palliative radiotherapy and initially exhibited a good clinical response. However, the patient succumbed at 18 months post-diagnosis due to dissemination of the disease. The literature on the extraneural metastasis of MB is also reviewed in the current study. IntroductionMedulloblastoma (MB) is the most common primary brain tumor in children; however, the malignancy rarely occurs in adults (1). In total, 7-10% of patients diagnosed with MB develop extraneural metastases, which most commonly involve the bone and lymph nodes, and recently, the frequency of reported extraneural metastases has increased (2-4). The visceral organs are less common sites of extraneural spread in medulloblastoma (5). It is generally believed that the overwhelming majority of cases reported with extraneural metastasis occur in patients who underwent a craniotomy (6). At present, typical treatments for high-risk childhood MB include maximal surgery, craniospinal radiation therapy and adjuvant chemotherapy (7-9). The 2-and 5-year overall survival rates following diagnosis of extraneural metastasis have been reported to be 31 and 26%, respectively (10). In general, the survival rate is considered to be poor. In the current study, the case of a 36-year-old male MB patient with recurrent disease involving the soft tissues of the occipital bone is presented, as well as the subsequent treatment course of the patient. In addition, the extraneural metastasis of MB is discussed. Written informed consent was obtained from the patient for the publication of this case report and any accompanying images. Case reportOn November 15, 2009, a 36-year-old male presented at the Binzhou Medical University Hospital (Binzhou, China) with nausea and vomiting that had persisted for 5 days, but was not accompanied by headache, visual impairment or ataxia. The patient had no significant previous medical history. Cranial magnetic resonance imaging (MRI) revealed the presence of a lesion in the fourth ventricle. Total spinal MRI revealed no evidence of additional central nervous system disease. Subsequently, three days after presentation, the patient underwent a posterior fossa craniotomy with gross total resection of the tumor, in which the cereb...

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Common Strategy for Adult and Pediatric Medulloblastoma: A Multicenter Series of 253 Adults

Cited by 139 publications

References 31 publications

Relative survival of childhood and adult medulloblastomas and primitive neuroectodermal tumors (PNETs)

Relative survival of childhood and adult medulloblastomas and primitive neuroectodermal tumors (PNETs)

Outcomes of Surgery and Craniospinal Radiotherapy for Adult Patients with Medulloblastoma

Medulloblastoma with soft-tissue and skeletal metastases in an adult: A case report

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