Community-acquired pneumonia in patients with chronic obstructive pulmonary disease requiring admission to the intensive care unit: Risk factors for mortality

Çilli, Aykut; Erdem, Hakan; Karakurt, Zühal; Türkan, Hülya; Yazicioglu-Mocin, Ozlem; Adıgüzel, Nalan; Güngör, Gökay; Bilge, Uğur; Tasci, Canturk; Yılmaz, Gülden; Öncül, Oral; Dogan-Celik, Aygul; Erdemli, Özcan; Öztoprak, Nefise; Samur, Anıl Aktaş; Tomak, Yakup; İnan, Asuman; Karaboga, Burcu; Tok, Demet; Temur, Sibel; Öksüz, Hafize; Şentürk, Özgür; Büyükkoçak, Ünase; Yılmaz-Karadağ, Fatma; Özcengiz, Dilek; Karakaş, Ahmet; Savasci, Umit; Ozgen-Alpaydın, Aylin; Kılıç, Elif; Elaldı, Nazif; Bilgiç, Hayati

doi:10.1016/j.jcrc.2013.08.004

Cited by 29 publications

(38 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Infectious etiology could be established in 21.3 to 78 % of the COPD patients with CAP [12][13][14][15][16][17][18][19][20][21]. Diagnostic yield was lower in two retrospective studies than in prospective studies [14,15].…”

Section: Microbial Etiologymentioning

confidence: 91%

“…Patients with COPD who are hospitalized with CAP are most likely to have previously received antibiotic therapy and have more severe respiratory failure and more severe pneumonia than those without COPD [12][13][14][15][16][17][18][19][20][21]. They also tend to be associated with more comorbidities such as cardiovascular diseases and diabetes mellitus, more systemic or inhaler corticosteroid use, more acidosis, and more alcohol abuse.…”

Section: Clinical Characteristics and Risk Factorsmentioning

confidence: 99%

“…Rello et al showed that P. aeruginosa was isolated with significantly higher frequency in COPD patients than in non-COPD patients (14.6 % vs 0.8, p<0.05) [13]. P. aeruginosa has been indicated by five of ten studies assessing CAP in the COPD subjects as being the first or second etiological agent [13,14,[16][17][18]. Two of these studies comprised patients with severe CAP requiring intensive care [13,16].…”

Section: Microbial Etiologymentioning

confidence: 99%

“…P. aeruginosa has been indicated by five of ten studies assessing CAP in the COPD subjects as being the first or second etiological agent [13,14,[16][17][18]. Two of these studies comprised patients with severe CAP requiring intensive care [13,16]. In one study, P. aeruginosa was the fourth most identifiable cause of CAP [12].…”

Section: Microbial Etiologymentioning

confidence: 99%

See 3 more Smart Citations

Community-Acquired Pneumonia in Patients with Chronic Obstructive Pulmonary Disease

Çilli

2014

Curr Infect Dis Rep

Self Cite

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Patients with COPD are at increased risk for community-acquired pneumonia (CAP). COPD has been reported as a comorbidity in at least one third of the hospitalized patients with CAP. There is a controversy that the presence of concomitant COPD and CAP is associated with a greater risk of death when compared to either condition alone. Risk factors, clinical and immunological characteristics, microbiological etiology, as well as prognosis and treatment of COPD patients with CAP are reviewed in this article.

show abstract

Section: Microbial Etiologymentioning

confidence: 91%

Section: Clinical Characteristics and Risk Factorsmentioning

confidence: 99%

Section: Microbial Etiologymentioning

confidence: 99%

Section: Microbial Etiologymentioning

confidence: 99%

See 2 more Smart Citations

Community-Acquired Pneumonia in Patients with Chronic Obstructive Pulmonary Disease

Çilli

2014

Curr Infect Dis Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…9 In a different study, the most important factors contributing to higher mortality in patients with COPD and CAP admitted to the intensive care unit (ICU) were the presence of bilateral lung infiltrates and prolonged mechanical ventilation, while systemic corticosteroid use and shorter length of ICU stay seemed to be protective against a fatal outcome. 10 Disease severity is also independently associated with worse outcomes, increasing mortality and complication rates. 11 In the long term follow-up, taking into account a 5-year period after the acute event, COPD, cardiovascular disease and malignancy were the leading causes of death.…”

Section: Introductionmentioning

confidence: 99%

The presence of COPD does not influence clinical outcomes in hospitalized patients with community-acquired pneumonia.

Silva¹,

Gearhart²,

Maciel³

et al. 2017

JRI

View full text Add to dashboard Cite

Introduction: Community acquired pneumonia (CAP) is a leading cause of death worldwide. Chronic obstructive pulmonary disease (COPD) is a well-established risk factor for development of CAP. What is not as clear is the impact of COPD on the outcomes of patients with CAP. In this study, we compared the outcomes of CAP in COPD and non-COPD patients. Methods: This was a retrospective cohort study. We conducted an analysis of the CommunityAcquired Pneumonia Organization (CAPO) international cohort study database, which includes patients with CAP admitted to several hospitals throughout the world. Patients were categorized into two groups based on the status of COPD: COPD positive or negative. Outcomes were time to clinical stability, length of hospital stay, and in-hospital mortality. Regression models were used to assess the independent effect of COPD on the outcomes. Results: This study included 7,325 patients. Of these, 1,869 (25.5%) had COPD. Patients with COPD had higher severity of illness (pneumonia severity index class V: 15% vs 9%; P <0.001). Accelerated failure time models with adjustment for co-variates showed no significant difference in the probability of clinical stability (P = 0.451) and of discharge (P = 0.232) in COPD vs. non-COPD patients. There was no difference in the crude in-hospital mortality between COPD and non-COPD patients (9% vs 9%; P = 0.37). Conclusion: Our study results show that COPD should not be considered a risk factor for poor outcomes in hospitalized patients with CAP.

show abstract

Infections in travellers returning to Turkey from the Arabian peninsula: a retrospective cross-sectional multicenter study

Erdem

Elaldı

et al. 2016

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

Mass gatherings pooling people from different parts of the world-the largest of which is to Mecca, Saudi Arabia, for Hajj-may impose risks for acquisition and dissemination of infectious diseases. A substantial number of pilgrims to Hajj and Umrah are Turkish citizens (456,000 in 2014) but data are lacking on scale of the problem. We did a retrospective cross-sectional multicenter study in Turkey to explore the range of infections among inpatients who had recently returned from the Arabian Peninsula. Our inclusion criteria were patients who had acquired an infection during their trip to an Arabian Peninsula country, or who became symptomatic within 1 week of their return. The data were collected retrospectively for January 1, 2013 and March 1, 2015. 185 Turkish patients were recruited to the study across 15 referral centers with travel associated infectious diseases after returning from Arabian Peninsula countries (predominantly Saudi Arabia 163 [88.1 %] for religious purposes 162 [87.5 %]). Seventy four (40.0 %) of them were ≥ 65 years old with numerous comorbidities including diabetes (24.3 %) and COPD (14.1 %). The most common clinical diagnosis was respiratory tract infections (169 [91.5 %]), followed by diarrheal diseases (13 [7 %]), and there was one case of MERS-CoV. Patients spent a median of 5 (3-7) days as hospital inpatients and overall mortality was 1.1 %. Returning travellers from the Arabian Peninsula present as inpatients with a broad range of infectious diseases similar to common community acquired infections frequently seen in daily medical practices in Turkey.

show abstract

Community-acquired pneumonia in patients with chronic obstructive pulmonary disease requiring admission to the intensive care unit: Risk factors for mortality

Cited by 29 publications

References 41 publications

Community-Acquired Pneumonia in Patients with Chronic Obstructive Pulmonary Disease

Community-Acquired Pneumonia in Patients with Chronic Obstructive Pulmonary Disease

The presence of COPD does not influence clinical outcomes in hospitalized patients with community-acquired pneumonia.

Infections in travellers returning to Turkey from the Arabian peninsula: a retrospective cross-sectional multicenter study

Contact Info

Product

Resources

About