Community screening for dementia: The Mini Mental State Exam (MMSE) and modified Mini-Mental State Exam (3MS) compared

McDowell, Ian; Kristjansson, Betsy; Hill, Gerry B.; Hébert, Réjean

doi:10.1016/s0895-4356(97)00060-7

Cited by 270 publications

(185 citation statements)

References 27 publications

Supporting

Mentioning

174

Contrasting

Unclassified

Order By: Relevance

“…Although we did not formally assess clinical dementia, when persons with low MMSE scores were removed from the sample, APOE-related effects disappeared. As low MMSE scores are associated with a higher likelihood of dementia (31,32), this finding is consistent with several other studies (e.g., 8, 9, 10) that demonstrate null 4-related effects when future dementia is controlled for. Given accumulating evidence that the subclinical phase of the disease extends years, and perhaps decades, ahead of the eventual clinical manifestations, the findings support the view that both APOE genotype and neuropsychological assessment could be taken into account in procedures for the early detection of dementia.…”

Section: Discussionsupporting

confidence: 91%

“…However, the MMSE criterion used in the present study drew upon work elsewhere (31,32), and was broader in excluding possible dementia cases than the Canberra Interview for the Elderly criteria which in the earlier study detected only 30 dementia cases at any time point (compared to n = 125 with MMSE ≤24 here). Although the MMSE is not a conclusive APOE and cognitive decline in late life 14 screening tool for dementia, we believe our approach represents a reasonable method of excluding possible dementia cases, given the constraints of available data.…”

Section: Discussionmentioning

confidence: 99%

“…Following consideration of the broader literature (31,32), participants with MMSE scores ≤ 24 at any assessment were excluded to assess whether any effects of APOE on cognitive performance were attributable to possible dementia. Norms for the MMSE indicate sensitivity of 95% and specificity of 82% for detecting Alzheimer's Disease at this cut point in community-based individuals who are 80 years or older with nine or more years of education (most participants in the present study were in this category by the second wave) (33).…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Apolipoprotein E ε4 and Later-Life Decline in Cognitive Function and Grip Strength

Batterham¹,

Bunce²,

Christensen³

2013

The American Journal of Geriatric Psychiatry

View full text Add to dashboard Cite

Objectives: Presence of the apolipoprotein E (APOE) 4 allele is a risk factor for dementia, while the 2 allele offers protection against dementia. There is also evidence for a relationship between APOE genotype and changes in cognitive function. It is not clear however, whether this relationship stems from undetected disease in persons genetically more vulnerable to dementia. This study examined whether APOE genotype was associated with either initial performance or change in performance on a range of cognitive and noncognitive tasks, after accounting for possible preclinical dementia.Design: A population-based cohort was assessed up to four times over 12 years. Participants:The sample was an Australian cohort of 590 participants aged 70 and over who were genotyped for APOE.Measurements: The outcomes were processing speed, verbal fluency, episodic memory, word recognition, face recognition, grip strength and reaction time.Results: Adjusted latent growth models indicated that 4 carriers had significantly poorer initial memory performance and greater declines in processing speed and word recognition, compared to 2 and 3 carriers. In addition, 2 carriers exhibited significantly less decline in right grip strength than 3 carriers. However, after excluding 125 participants with low global cognition scores, all genotype effects became non-significant.Conclusions: Over a 12 year period, findings indicate that APOE 4-related cognitive decline in older community-dwelling populations is due to a higher likelihood of preclinical dementia among 4 carriers. When possible dementia cases are removed from the analyses, 4 associations with cognitive decline become statistically unreliable. APOE and cognitive decline in late life 3

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Apolipoprotein E ε4 and Later-Life Decline in Cognitive Function and Grip Strength

Batterham¹,

Bunce²,

Christensen³

2013

The American Journal of Geriatric Psychiatry

View full text Add to dashboard Cite

show abstract

“…I noen av studiene har man kun brukt MMSE (mini mental status), som er en god screening for global kognitiv funksjon, men som har begrenset sensitivitet. Dette bekreftes av Murray og medarbeidere, som brukte et bredt nevropsykologisk testbatteri og fant at kun 21 % av dem som ble vurdert til å ha alvorlig kognitiv svikt, ble avdekket ved hjelp av en modifisert versjon av MMSE (7,15,16). Eksekutive funksjoner synes å vaere saerlig affisert (7,9).…”

Section: Forekomst Av Kognitiv Sviktunclassified

Kognitiv svikt ved terminal nyresykdom

Sæle

Sønnesyn²,

Svarstad³

et al. 2009

Tidsskriftet

View full text Add to dashboard Cite

“…In community-dwelling older people, a combination of functional activities questionnaire score 15 with Mini Mental State Examination (MMSE) score 16 and age had an AUC of 0.95. 17 However, the MMSE is relatively time-consuming (between 7 and 18 minutes) 18 and copyright-protected. GPs commonly report lack of time as a barrier to diagnosing dementia.…”

Section: Introductionmentioning

confidence: 99%