Community-wide versus school-based targeted deworming for soil-transmitted helminth control in school-aged children in Vietnam: the CoDe-STH cluster-randomised controlled trial

Dyer, Clare E.F.; Ng-Nguyen, Dinh; Clarke, Naomi E.; Hii, Sze Fui; Nguyen, Hieu Quoc; Nguyen, Van-Anh Thi; Nguyen, Thai Van; Nguyen, Trong Van; Ngo, Tam Thi; Herath, H.M.P. Dilrukshi; Wand, Handan; Coffeng, Luc E.; Marshall, Justine C.; Gray, Darren J.; Anderson, Roy M.; Clements, Archie C.A.; Kaldor, John M.; Traub, Rebecca J.; Vaz Nery, Susana

doi:10.1016/j.lanwpc.2023.100920

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…This strategy aims to lower the burden and occurrence of STHs, including hookworms (World Health Organization 2017). A recent study revealed that community-wide MDA and school-based MDA are equally effective at reducing hookworm infections among schoolaged children in Vietnam (Dyer et al 2023). In the same region of Vietnam, community-based and school-based MDA were found to cost approximately 0.27 USD and 0.43 USD per individual, respectively (Delos Trinos et al 2023).…”

Section: Treatment Control and Eliminationmentioning

confidence: 99%

Ancylostoma ceylanicum and other zoonotic canine hookworms: neglected public and animal health risks in the Asia–Pacific region

Tenorio,

Tabios,

Inpankaew

et al. 2024

Animal Diseases

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Zoonotic hookworm infections remain a significant public health problem, causing nearly 500 million cases globally and approximately four million disability-adjusted life years lost annually. More than one-fifth of these cases are attributed to Ancylostoma ceylanicum, an emerging zoonotic health issue in the Asia-Pacific region. This review presents key research gaps regarding the epidemiology, diagnosis, control, prevention and elimination of A. ceylanicum and other canine zoonotic hookworms as neglected health threats. A. ceylanicum is the second most prevalent human hookworm in the region; it is the most common hookworm among dogs and cats-reservoirs of zoonotic infections. Previous population genetic and phylogenetic analyses revealed that A. ceylanicum has three possible transmission dynamics: zoonotic, animal-only, and human-only pathways. The actual burden of zoonotic ancylostomiasis in most endemic countries remains unknown due to the use of parasitological techniques (e.g., Kato-Katz thick smear and floatation techniques) that have reduced diagnostic performance and do not allow accurate species identification in helminth surveys. The emergence of benzimidazole resistance in soil-transmitted helminths (STHs), including hookworms, is a concern due to the protracted implementation of mass drug administration (MDA). Resistance is conferred by single nucleotide polymorphisms (SNPs) that occur in the β-tubulin isotype 1 gene. These mutations have been reported in drug-resistant A. caninum but have not been found in A. ceylanicum in the field. A. ceylanicum remains understudied in the Asia-Pacific region. The zoonotic nature of the parasite warrants investigation of its occurrence in human and animal reservoir hosts to understand the dynamics of zoonotic transmission in different endemic foci. The detection of benzimidazole resistance-associated SNPs in zoonotic hookworms from Asia-Pacific countries has yet to be thoroughly explored. Considering the high level of hookworm endemicity in the region, the circulation of resistant isolates between humans and animals potentially presents a significant One Health threat that can undermine current MDA and proposed animal deworming-based control efforts.

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Section: Treatment Control and Eliminationmentioning

confidence: 99%

Ancylostoma ceylanicum and other zoonotic canine hookworms: neglected public and animal health risks in the Asia–Pacific region

Tenorio,

Tabios,

Inpankaew

et al. 2024

Animal Diseases

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show abstract

“…Recently published in The Lancet Regional Health—Western Pacific, the CoDe-STH trial in Vietnam 3 contributes to the growing body of evidence supporting community-based MDA for hookworm. CoDe-STH extends established results from meta-analyses 4 and other large-scale trials such as TUMIKIA (Kenya), 5 Deworm3 (India, Malawi, and Benin), 6 and Geshiyaro (Ethiopia).…”

mentioning

confidence: 99%

Community-based deworming for hookworm benefits children treated within schools and is cost-effective due to economies of scale: the CoDe-STH trial

Chami

2023

The Lancet Regional Health - Western Pacific

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Community-wide versus school-based targeted deworming for soil-transmitted helminth control in school-aged children in Vietnam: the CoDe-STH cluster-randomised controlled trial

Cited by 2 publications

References 19 publications

Ancylostoma ceylanicum and other zoonotic canine hookworms: neglected public and animal health risks in the Asia–Pacific region

Ancylostoma ceylanicum and other zoonotic canine hookworms: neglected public and animal health risks in the Asia–Pacific region

Community-based deworming for hookworm benefits children treated within schools and is cost-effective due to economies of scale: the CoDe-STH trial

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