Comorbid disorders associated with asthma in children in Germany – National analysis of pediatric primary care data

Jacob, Louis; Keil, Thomas; Kostev, Karel

doi:10.1111/pai.12656

Cited by 15 publications

(14 citation statements)

References 23 publications

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“…This is in agreement with another primary healthcare study. 2 An explanation for this could be that airway infections increase asthma symptoms or vice versa, and that asthma resulted in increased susceptibility for infection, which increased their motivation to visit the GPs. Furthermore, the awareness of parents is likely to be increased when a child suffers from asthma, since such an infection could predispose for an asthma exacerbation.…”

Section: Discussionmentioning

confidence: 99%

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Risks for comorbidity in children with atopic disorders: an observational study in Dutch general practices

et al. 2017

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ObjectiveThis study aimed to investigate both atopic and non-atopic comorbid symptoms and diseases in children with physician-diagnosed atopic disorders (atopic eczema, asthma and allergic rhinitis).MethodsAll children aged 0–18 years listed in a nationwide primary care database (the Netherlands Institute for Health Services Research-Primary Care Database) with routinely collected healthcare data in 2014 were selected. Children with atopic disorders were matched on age and gender with non-atopic controls within the same general practice. A total of 404 International Classification of Primary Care codes were examined. Logistic regression analyses were performed to examine the associations between the presence of atopic disorders and (non-)atopic symptoms and diseases by calculating ORs.ResultsHaving one of the atopic disorders significantly increased the risk of having other atopic-related symptoms, even if the child was not registered as having the related atopic disorder. Regarding non-atopic comorbidity, children with atopic eczema (n=15 530) were at significantly increased risk for (infectious) skin diseases (OR: 1.2–3.4). Airway symptoms or (infectious) diseases (OR: 2.1–10.3) were observed significantly more frequently in children with asthma (n=7887). Children with allergic rhinitis (n=6835) had a significantly distinctive risk of ear-nose-throat-related symptoms and diseases (OR: 1.5–3.9). Neither age nor gender explained these increased risks.ConclusionGeneral practitioners are not always fully aware of relevant atopic and non-atopic comorbidity. In children known to have at least one atopic disorder, specific attention is required to avoid possible insufficient treatment and unnecessary loss of quality of life.

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Section: Discussionmentioning

confidence: 99%

“…However, limited data are available on the comorbidities of children with atopic disorders in primary care. 2 In the present study we refer to atopy as a (genetic) predisposition towards developing certain allergic hypersensitivity. Therefore the clinical manifestation of atopy is allergy.…”

Section: Introductionmentioning

confidence: 99%

Risks for comorbidity in children with atopic disorders: an observational study in Dutch general practices

et al. 2017

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“…In the general population, the prevalence of obesity varies by country and ranges from 4 to 38% 80 . In a study of 6-17-year-old patients with asthma, obesity appeared to increase with age (8% in 6-9-year-olds, 14% in 10-13-year-olds and 16% in 14-17-year-olds) 61 .…”

Section: Obesity Prevalencementioning

confidence: 97%

Impact of comorbid conditions on asthmatic adults and children

Kaplan

Szefler

Halpin

2020

npj Prim. Care Respir. Med.

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Comorbid conditions (comorbidities) can complicate the diagnosis and management of asthma. In different age groups, comorbid conditions can present varying challenges, including diagnostic confusion due to mimicking asthma symptoms, exacerbation of asthma symptoms, therapy for comorbid conditions affecting asthma or therapy for asthma affecting these conditions. This review aims to summarise some common comorbid conditions with asthma, such as rhinitis, vocal cord dysfunction, gastro-oesophageal reflux, psychiatric disorders, obesity and obstructive sleep apnoea, and discuss their prevalence, symptoms, diagnosis and treatment, highlighting any differences in how they impact children and adults. Overall, there is a lack of data on the impact of treating comorbid conditions on asthma outcomes and further studies are needed to guide age-appropriate asthma management in the presence of these conditions.

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“…This result corresponds to studies from Germany and Korea. 15,16 Respiratory infection has been documented to be the major trigger of AE; as high as 80% of pediatric AE episodes are caused by viral respiratory infections. 13 Thus, respiratory infection must be considered when analyzing the adequacy of acetaminophen/NSAID COX-1 use in pediatric asthmatic patients.…”

Section: Discussionmentioning

confidence: 99%

Impact of antipyretics on acute asthma exacerbation during respiratory infection—A nationwide population-based study

Chung

Huang

Chen

et al. 2020

Pediatrics & Neonatology

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Comorbid disorders associated with asthma in children in Germany – National analysis of pediatric primary care data

Abstract: Overall, this study, based on primary healthcare data, found a considerably high prevalence of several comorbid diseases in German children with asthma.

Cited by 15 publications

References 23 publications

Risks for comorbidity in children with atopic disorders: an observational study in Dutch general practices

Risks for comorbidity in children with atopic disorders: an observational study in Dutch general practices

Impact of comorbid conditions on asthmatic adults and children

Impact of antipyretics on acute asthma exacerbation during respiratory infection—A nationwide population-based study

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