Comorbidities and predicting the outcome of COVID-19: the treatment results of 13,585 patients hospitalized in the Moscow Region

Молочков, А. В.; Karateev, D.; Ogneva, E. Yu.; Zulkarnaev, Aleksei; Лучихина, Е. Л.; Макарова, И. В.; Morozov, S. V.

doi:10.18786/2072-0505-2020-48-040

Cited by 20 publications

(4 citation statements)

References 15 publications

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“…As the national healthcare agenda is focused on pandemic-related somatic burden ( 25 ), existing comorbidities ( 26 ), and mental health risks ( 27 ), the evidence reported in our study will invigorate knowledge consolidation for a prompt response to potential infection outbreaks and future public health challenges.…”

Section: Discussionmentioning

confidence: 90%

Health behavior in Russia during the COVID-19 pandemic

Peshkovskaya,

Galkin

2023

Front. Public Health

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In this article, we report results from a nationwide survey on pandemic-related health behavior in Russia. A total of 2,771 respondents aged 18 to 82 were interviewed between January 21 and March 3, 2021. The survey included questions on perceived vulnerability to coronavirus, prevention-related health behavior, readiness for vaccination, and general awareness about COVID-19. Descriptive data showed that 21.2% of respondents reported high vulnerability to the coronavirus, and 25% expressed fear. Moreover, 38.7% of the surveyed individuals reported low trust in vaccination efficacy, and 57.5% were unwilling to take a vaccine, which was much higher than the official data. Based on the evidence obtained, four types of health behavior during the pandemic were constructed. Rational (29.3%) and denying (28.6%) behaviors prevailed in men, while women were found to more likely behave with a vaccine-hesitant demeanor (35.7%). Educational background affected the proportion of respondents with the denying type of health behavior, who were also of younger age. The rational behavioral type was found to be more common among respondents aged above 50 years and prevailed as well among individuals with university degrees. The middle-aged population of Russia was highly compliant with prevention-related health practices; however, vaccine hesitancy was also high among them. Furthermore, health behaviors varied significantly across the Federal Districts of Russia. We are convinced that our results contribute to existing public health practices and may help improve communication campaigns to cause positive health behaviors.

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Section: Discussionmentioning

confidence: 90%

Health behavior in Russia during the COVID-19 pandemic

Peshkovskaya,

Galkin

2023

Front. Public Health

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“…В. Молочков и др. [24] указывают, что в отсутствие коморбидных состояний частота летального исхода при COVID-19 у небеременных составляет 9,4 %, мультиморбидность повышает частоту неблагоприятного исхода до 24,8 %. Коморбидность является одним из определяющих факторов прогноза внутрибольничной летальности у пациентов с COVID-19 [24].…”

Section: Original Articleunclassified

Clinical and Laboratory Features and Maternal Outcomes in Pregnant Women with Critical Lung Damage in the COVID-19

Voropaeva,

Khaidukova,

Kazachkova

et al. 2024

Урал. мед. журнал

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Introduction. The spread of the delta strain of the SARS-CoV-2 virus during the third and fourth waves of the pandemic led to the fact that a large cohort of pregnant women and maternity women needed respiratory support, standard treatment methods had no effect, and negative outcomes for the mother and fetus has increased.Purpose of the study. The aim is to determine clinical and laboratory features and maternal outcomes in pregnant women with the coronavirus disease 2019 (COVID-19) and critical lung damage.Materials and methods. A comparative study was conducted, followed by a retrospective analysis of clinical and laboratory features, maternal outcomes in 56 pregnant women with COVID-19 treated in this maternity hospital in the first-fourth wave of the pandemic. The research method is continuous, sequential. The first group (main) consisted of 28 women with severe or extremely severe form of the course of COVID-19 and critical lung damage (more 75 %); The second group (comparison) — 28 pregnant women with a moderate form of the disease and lung damage of 25–50 %. Screening assessment of the degree of endogenous intoxication was carried out. The severity of the disease was determined by the evaluation scale National Early Warning Score (NEWS).Results. Laboratory parameters of patients at admission and at the height of the disease have statistically significant differences in the general blood test, such as higher levels of leukocytes, eosinophils, rod-shaped neutrophils, hemoglobin, as well as lymphopenia and monocytopenia in women of the main group at the height of the disease. At the same time, the hematological indices of intoxication in the main group exceed the value of these indicators in the comparison group by two times. Patients of both groups had high levels of acute-phase markers of inflammation — C-reactive protein and ferritin, — an indicator of tissue destruction of lactate dehydrogenase, however, both at admission and at the height of the disease, these indicators were statistically significantly higher in the group of women with critical lung damage. In general, 20/28 patients (71.4 %) of group 1 had an extremely severe course of the disease, 8/28 (28.6 %) had a severe course. In second group, 28/28 patients (100 %) had moderate-severe NCI (p = 0.000), while recovery was noted in all of them. Outcomes of COVID-19 in women with critical lung damage: recovered — 25/28 (89 %); 3/28 (10.7 %) the patients died from complications of COVID-19 of an extremely severe degree.Discussion. The most frequent laboratory anomaly was leukocytosis and a rod-shaped shift in the midst of the disease in women with critical lung damage, as well as a statistically significant increase in the level of C-reactive protein, lactate dehydrogenase, D-dimer. Pulmonary complications (parapneumonic pleurisy, pneumothorax, pneumomediastinum, hydrothorax, lung abscess) and extrapulmonary complications (encephalopathy, panic attacks, acute liver injury, sepsis, thromboembolic complications) were observed only with critical lung damage.Conclusion. In the laboratory, at the height of the disease, in the group of pregnant women with critical lung damage, leukocytosis and stab shift are statistically significantly more common. Hematological indices of intoxication, leukocyte and hematological, confirm endogenous intoxication at the height of the disease. A statistically significantly higher level of aspartate aminotransferase, lactate dehydrogenase, C-reactive protein, D-dimer is determined upon admission to the hospital and at the height of the disease as markers of systemic inflammatory response and cytolysis, which demonstrates the defeat of several organ systems simultaneously.

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“…Исследования, изучающие факторы риска развития COVID-19 в когортах с большой численностью обследованных, единичные [8][9][10][11] Проведенный Китайским центром по контролю и профилактике заболеваний анализ выживаемости 44 672 пациентов с подтвержденным COVID-19 показал, что мужской пол, пожилой возраст, а также лейкоцитоз и высокий уровень лактатдегидрогеназы (ЛДГ), поражение сердца, гипергликемия и применение высоких доз кортикостероидов имели прямую связь с летальностью при тяжелой форме COVID-19 [10]. При тяжелых случаях заболевания у госпитализированных пациентов чаще, чем при среднетяжелом течении, выявляли артериальную гипертензию (38,7% и 22,2%; р=0,0001), СД (19,3% и 11,1%; р=0,009), ишемическую болезнь сердца (ИБС) (10,4% и 2,2%; р=0,0001), хроническую обструктивную болезнь легких (4,8% и 1,4%; р=0,026).…”

Section: факторы риска тяжелого течения Covid-19unclassified

“…На основании базы данных 66 больниц Московской области, работающих в системе обязательного медицинского страхования, за период с 1 апреля по 23 июня 2020 г. проведен анализ данных 13 585 человек с диагнозом COVID-19 (женщин -53,7%, мужчин -46,3%; средний возраст 56,5±14,9 года; медиана 57 [46; 67] лет) [11]. У всех пациентов вирус был идентифицирован (код U07.1 по МКБ-10) с помощью qPCR на вирус SARS-CoV-2 в материале мазка из носоглотки и ротоглотки.…”

Section: факторы риска тяжелого течения Covid-19unclassified

Risk factors, immunological mechanisms and biological markers of severe COVID-19 course (study overview)

Биличенко¹

2021

Russian Medical Inquiry

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The article presents the conducted analysis of risk factors, immunological mechanisms and biological markers of the severe COVID-19 course. Official statistical data and scientific publications on the problem of assessing the risk of severe COVID-19 course were used in this analysis. It was found that elderly age, male gender, the presence of comorbidity (diabetes mellitus, cardiovascular, respiratory, renal and autoimmune diseases, and immunodeficiency conditions) increase the risk of an adverse outcome in COVID-19. The following immunological mechanisms of the disease manifestation and prognostic significance of different biological markers were determined: elevated levels of SAA, C-reactive protein, procalcitonin, IL-6, urea, creatinine, direct bilirubin, LDH, D-dimer and serum cholinesterase. Lymphopenia (abnormally low level of lymphocytes) and neutrophil-to-lymphocyte ratio (NLR) are the most common described prognostic markers in COVID-19. Thrombocytopenia and elevated D-dimer levels may indicate coagulopathies in patients with COVID-19 and predict morbidity and mortality even at the onset. Thus, the determination of risk factors and levels of inflammatory markers (commonly found in severe cases of COVID-19) should be used to choose the right treatment tactics to improve the clinical outcome. KEYWORDS: COVID-19, risk factors, immunological mechanisms, comorbidity, biological markers. FOR CITATION: Bilichenko T.N. Risk factors, immunological mechanisms and biological markers of severe COVID-19 course (study overview). Russian Medical Inquiry. 2021;5(5):237–244 (in Russ.). DOI: 10.32364/2587-6821-2021-5-5-237-244.

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Comorbidities and predicting the outcome of COVID-19: the treatment results of 13,585 patients hospitalized in the Moscow Region

Cited by 20 publications

References 15 publications

Health behavior in Russia during the COVID-19 pandemic

Health behavior in Russia during the COVID-19 pandemic

Clinical and Laboratory Features and Maternal Outcomes in Pregnant Women with Critical Lung Damage in the COVID-19

Risk factors, immunological mechanisms and biological markers of severe COVID-19 course (study overview)

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