Comorbidities are associated with self-reported sleep-disordered breathing and insomnia: a cross-sectional study from China

Li, Shengnan; Tan, Siyue; Liu, Dong; Zhang, Ke; Zhang, Yuyi; Wang, Bo; Zuo, Hui

doi:10.1007/s11325-023-02875-4

Sleep Breath

2023

DOI: 10.1007/s11325-023-02875-4

|View full text |Cite

Comorbidities are associated with self-reported sleep-disordered breathing and insomnia: a cross-sectional study from China

Shengnan Li,

Siyue Tan,

Dong Liu

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Association of healthy lifestyle with self-reported sleep disordered breathing: A cross-sectional study

Sun,

Yang,

Xia

et al. 2024

Sleep Medicine

View full text Add to dashboard Cite

Association of healthy lifestyle with self-reported sleep disordered breathing: A cross-sectional study

Sun,

Yang,

Xia

et al. 2024

Sleep Medicine

View full text Add to dashboard Cite

APOBR Is Downregulated in EBV+ Tonsils of Children with Obstructive Sleep-Disordered Breathing

Santos-Cortez,

Gomez,

Elling

et al. 2024

Genes

View full text Add to dashboard Cite

Background: Obstructive sleep-disordered breathing (oSDB) is a heterogeneous phenotype that is increasing in prevalence worldwide and has many potential comorbidities that could severely affect quality of life. There is a need to identify biomarkers for oSDB and its comorbidities to improve clinical management, particularly in children. Methods: We performed bulk mRNA-sequencing, differential expression analysis, and qPCR replication of selected differentially expressed genes (DEGs) using RNA samples extracted from tonsils of children with oSDB. Two variables were used as classifier, namely, detection of Epstein–Barr virus (EBV) in tonsils and need for continuous positive airway pressure (CPAP) treatment. Standard statistical tests were used to determine associations across clinical, EBV, and DEG variables. Results: Nineteen genes were dysregulated in tonsils that are EBV+ or from children needing CPAP. Of these genes, APOBR was downregulated in both EBV+ and CPAP+ tonsils, and this downregulation was replicated by qPCR in an independent set of pediatric samples. In the tonsils of adult patients with oSDB, APOBR was positively correlated with age, and potentially with diastolic blood pressure. Conclusions: Taken together, APOBR and DEGs in tonsillar tissues may be useful as potential biomarkers of oSDB severity and comorbidity across the lifespan, with APOBR levels being dependent on latent EBV infection.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Comorbidities are associated with self-reported sleep-disordered breathing and insomnia: a cross-sectional study from China

Cited by 2 publications

References 37 publications

Association of healthy lifestyle with self-reported sleep disordered breathing: A cross-sectional study

Association of healthy lifestyle with self-reported sleep disordered breathing: A cross-sectional study

APOBR Is Downregulated in EBV+ Tonsils of Children with Obstructive Sleep-Disordered Breathing

Contact Info

Product

Resources

About