Comorbidities in Chronic Obstructive Pulmonary Disease

Chatila, Wissam; Thomashow, Byron; Minai, Omar A.; Criner, Gerard J.; Make, Barry J.

doi:10.1513/pats.200709-148et

Cited by 394 publications

(310 citation statements)

References 117 publications

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“…The reported prevalence of diabetes among patients with COPD ranges from 1.6 to 16% in western countries, and there is evidence of an interaction between diabetes and COPD (Chatila et al 2008). However, our study, which included patients with COPD with a first hospitalization, appeared to have higher a HR, hazard ratio; CI, confidence interval.…”

Section: Discussionmentioning

confidence: 99%

Disease Severity at the First Hospitalization as a Predictor for Mechanical Ventilation Dependency in Elderly Patients with Chronic Obstructive Pulmonary Disease

Liao

Lin

et al. 2014

Tohoku J. Exp. Med.

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Patients with chronic obstructive pulmonary disease (COPD) are predisposed to respiratory failure with ventilator dependency. This study aims to determine the risk of prolonged mechanical ventilation (PMV), defined as 22 days or more of mechanical ventilation dependency after the first day of hospital admission (index date) in patients diagnosed with COPD. A retrospective cohort was conducted using medical claim data of Taiwan's National Health Insurance Research Database. Eligible study subjects were those who had a diagnosis of COPD made between January 1, 2005 and December 31, 2009. Patients were then followed until being registered as a PMV case, death, or the end of the study. The comorbidities were measured from January 1, 1997 to the index date by the ICD-9 code. The study sample consisted of 6,341 patients with COPD with a mean age of 73.89 (± 12.01) years. Over a maximum of 6 years of follow-up, 654 patients developed PMV dependency, with an incidence density of 41.56 per 1,000 person-years. Patients aged 70 years and older were at significantly increased risk for PMV dependency, compared to those aged 40-49 years after adjusting for confounders. Expenses per visit and hospital visits per year, representing the severity of the COPD, were also associated with an elevated risk of PMV. Most patients developed PMV dependency within the first two years after the index date. Physicians should be aware that elderly patients with COPD have a high risk of PMV after first hospitalization, and these patients need to be closely monitored.

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Section: Discussionmentioning

confidence: 99%

Disease Severity at the First Hospitalization as a Predictor for Mechanical Ventilation Dependency in Elderly Patients with Chronic Obstructive Pulmonary Disease

Liao

Lin

et al. 2014

Tohoku J. Exp. Med.

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“…Three studies conducted reported that the anemia prevalences in COPD are 23%, 21%, and 15%. 6,11 Anemia could be caused by many conditions or diseases, including bleeding, malignancies, chronic kidney disease (CKD). Those conditions or diseases were found in subjects in this study and there was no control over those conditions.…”

Section: Figure 4 Proportion Of Comorbidity According To Smoking Historymentioning

confidence: 99%

“…It supports the previous study in which the prevalence of DM type 2 in COPD patients is between 1.6-16%. 6 Based on several studies, diabetes in COPD is caused by pro-inflammatory cytokine (TNF-α and IL-6) which can block signal through insulin receptor; as the result, insulin resistance is occurred. Therefore, COPD patient has a higher risk to have DM type 2.…”

Section: Figure 4 Proportion Of Comorbidity According To Smoking Historymentioning

confidence: 99%

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Comorbidity among Hospitalized Patients with Chronic Obstructive Pulmonary Disease in a Teaching Hospital, West Java Indonesia

Aini¹,

Suryadinata²,

Herdiningrat³

2015

amj

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Background: One of the most important causes that can increase the risk of hospitalization and death in chronic obstructive pulmonary disease is comorbidity. The aim of this study was to identify the proportion of comorbidity among hospitalized patients with chronic obstructive pulmonary disease in a teaching hospital, West Java, Indonesia, from January to December 2012. Methods: A descriptive study was conducted from September to November 2013 in Internal Medicine Department of Dr. Hasan Sadikin General Hospital Bandung. The study used 107 medical records that consisted of data about patients with chronic obstructive pulmonary disease (COPD) who were hospitalized between January to December 2012. The medical records were collected using simple random sampling. Variables identified in this study were characteristics of the patients (age, sex, and smoking history) and comorbidity events. Comorbidity events were coronary artery disease (CAD), lung cancer, diabetes mellitus (DM) type 2, anemia, dyslipidemia, osteoporosis, depression, pulmonary artery hypertension (PAH), and hypertension. Age variable was divided into 3 categories with interval 20 years. All collected data were presented in frequency distribution. Results: Most of the patients in this study were 50-69 years old, male, and had smoking history. The highest proportion of comorbid condition was hypertension, followed by anemia and coronary artery disease. Conclusions: Patients with COPD have one or more other diseases (comorbidity). Three most frequent comorbidities are hypertension, anemia, and coronary artery disease. [AMJ.2015;2(4):

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“…KOAH'ın prevelansının yüksek olmasına bağlı olarak, KOAH'a bağlı pulmoner hipertansiyon (PH), PH nedenlerinin arasında en sık görü-len nedenlerinden biridir (1). Yapılan çalışmalarda, KOAH tanılı olgularda PH prevelansı %30-70 arasın-da bulunmuştur (2)(3)(4). Bu olguların çoğunun, ortalama pulmoner arter basıncı (PAB) 20-35 mmHg iken, olguların %3-5'inde 35-40 mmHg arasında olduğu görülmüştür (5).…”

Section: Introductionunclassified