Compact multichannel spectroscopic label-free biosensor platform for plant diseases point-of-care testing (POCT)

Sensing of COVID-19 spike protein in nasopharyngeal samples using a portable surface plasmon resonance diagnostic system

“…15 The interest of SPR is broad and includes its use for the understanding of avidity-induced affinity enhancements for the SARS-CoV-2 spike protein and ACE2 interaction, 16 a screening approach of affinity constants between bioreceptors and viral proteins, 17,18 as well as a rapid diagnostic tool for detection of SARS-CoV-2 antibodies 19 involved in severe acute respiratory syndrome 20 and more recently for the diagnosis of COVID-19 infection. 21–23 While the large size of the instrument has been a limitation for a large implementation in diagnostics, portable SPR devices in the wavelength interrogation mode 21,24–27 display unique point-of-care features allowing viral sensing under safe conditions and optimal detection protocols offered by emerging machine learning tools. 28 Huang et al 21 developed recently a spike protein specific plasmonic sensor and tested its performance on a SARS-CoV-2 pseudovirus.…”