Compacted cancellous bone has a spring-back effect

Kold, Søren; Bechtold, Joan E.; Ding, Ming; Chareancholvanich, Keerati; Rahbek, Ole; Søballe, Kjeld

doi:10.1080/00016470310018018

Cited by 39 publications

(30 citation statements)

References 20 publications

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“…This certainly reflects the mechanical stress following press-fit insertion and spring-back effect of bone (Kold et al, 2003). With a different surgical protocol, the stress distribution would certainly be different, and Y(x) would have to be re-calculated.…”

Section: Article In Pressmentioning

confidence: 99%

Prediction of bone density around orthopedic implants delivering bisphosphonate

Stadelmann¹,

Terrier²,

Gauthier³

et al. 2009

Journal of Biomechanics

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a b s t r a c tThe fixation of an orthopedic implant depends strongly upon its initial stability. Peri-implant bone may resorb shortly after the surgery. This resorption is directly followed by new bone formation and implants fixation strengthening, the so-called secondary fixation. If the initial stability is not reached, the resorption continues and the implant fixation weakens, which leads to implant loosening. Studies with rats and dogs have shown that a solution to prevent peri-implant resorption is to deliver bisphosphonate from the implant surface.The aims of the study were, first, to develop a model of bone remodeling around an implant delivering bisphosphonate, second, to predict the bisphosphonate dose that would induce the maximal peri-implant bone density, and third to verify in vivo that peri-implant bone density is maximal with the calculated dose.The model consists of a bone remodeling equation and a drug diffusion equation. The change in bone density is driven by a mechanical stimulus and a drug stimulus. The drug stimulus function and the other numerical parameters were identified from experimental data. The model predicted that a dose of 0.3 mg of zoledronate on the implant would induce a maximal bone density. Implants with 0.3 mg of zoledronate were then implanted in rat femurs for 3, 6 and 9 weeks. We measured that peri-implant bone density was 4% greater with the calculated dose compared to the dose empirically described as best.The approach presented in this paper could be used in the design and analysis processes of experiments in local delivery of drug such as bisphosphonate.

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Section: Article In Pressmentioning

confidence: 99%

Prediction of bone density around orthopedic implants delivering bisphosphonate

Stadelmann¹,

Terrier²,

Gauthier³

et al. 2009

Journal of Biomechanics

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“…Micro-CT in vitro scanning has been widely used for bone samples obtained from all sizes of animal, such as mouse [2,[75][76][77], rat [175], guinea pig [44], rabbit [52,149], dog [28,46,85,101,102], pig [106,107] sheep [7,37], and human [29,51,[64][65][66][67]. In vivo micro-CT imaging can now also be applied to all sizes of animals depending on the location to be scanned.…”

Section: ) In Vivo Micro-ct For Animal Researches and For Humanmentioning

confidence: 99%

Microarchitectural adaptations in aging and osteoarthrotic subchondral bone issues

Ding

2010

Acta Orthopaedica

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“…Cancellous bone has an organic component with elasticity, 14,29 therefore recoil of the graft after removing the proximal tamps may lead to a thinner than expected cement mantle. 16 Recoil is probably much less with pure ceramic granules.…”

Section: Discussionmentioning

confidence: 99%

A Hydroxyapatite Graft Substitute Reduces Subsidence in a Femoral Impaction Grafting Model

Munro

Downing²,

Meakin³

et al. 2007

Clinical Orthopaedics and Related Research

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Synthetic bone graft substitutes have been developed for impaction grafting revision hip surgery in response to concerns about the availability and potential infection risk of allograft. We performed an in vitro experiment to determine whether a synthetic porous hydroxyapatite material might improve resistance to cumulative subsidence and cyclic (elastic) movement on loading. We impacted different ratios of hydroxyapatite and allograft (0%, 50%, 70%, and 90% hydroxyapatite) into composite femoral models (eight per group) and implanted tapered, polished stems with cement. Models were loaded for 18,000 cycles on a servohydraulic materials testing machine. Migration of the femoral prostheses and the distal cement was determined using radiostereometric analysis, and cyclic movement was measured mechanically by the testing machine. Hydroxyapatite decreased overall subsidence and subsidence at the prosthesis-cement interface, but there was no difference at the cement-femur interface. This decrease may have occurred because the hydroxyapatite-containing graft was more rigid, or because it resulted in a thicker cement mantle. Cyclic prosthesis movement also was lower with hydroxyapatite. While the biologic response to porous hydroxyapatite remains to be determined, its mechanical properties appear promising.

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Compacted cancellous bone has a spring-back effect

Cited by 39 publications

References 20 publications

Prediction of bone density around orthopedic implants delivering bisphosphonate

Prediction of bone density around orthopedic implants delivering bisphosphonate

Microarchitectural adaptations in aging and osteoarthrotic subchondral bone issues

A Hydroxyapatite Graft Substitute Reduces Subsidence in a Femoral Impaction Grafting Model

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