Comparable responses to a wide range of olfactory stimulation in women and men

Lillqvist, Moa; Claeson, Anna-Sara; Zakrzewska, Marta; Andersson, Linus

doi:10.1038/s41598-023-35936-5

Cited by 5 publications

(2 citation statements)

References 59 publications

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“…Hormonal influence on tumour growth has been discussed in previous studies [31,32]. Thus, although the concept connecting women's olfactory superiority to the cellular composition of the olfactory bulb has been suggested, the current body of research presents contradictory results [33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Correlation of Molecular Status with Preoperative Olfactory Function in Olfactory Groove Meningioma

Podlesek,

Beyer,

Alkhatib

et al. 2024

Cancers

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Purpose: The study aims to examine the possible correlation between genomic alterations and preoperative olfactory function in patients with olfactory groove meningioma (OGM), due to the frequent presence of olfactory impairment. Methods: We utilised next-generation sequencing to analyse samples from 22 individuals with OGM in order to detect driver mutations. Tumour morphology was assessed using preoperative imaging, whereas olfactory function was examined using Sniffin’ Sticks. Results: In a study of 22 OGM patients, mutations were as follows: 10 with SMO/SUFU, 7 with AKT1, and 5 as wild type. Planum sphenoidale hyperostosis (PSH) was present in 75% of patients, showing significant variation by mutation (p = 0.048). Tumour volumes, averaging 25 cm3, significantly differed among groups. PSH negatively impacted olfaction, notably affecting odour threshold, discrimination, identification, and global olfactory performance score (TDI) (p values ranging from <0.001 to 0.003). Perifocal oedema was associated with lower TDI (p = 0.009) and altered threshold scores (p = 0.038). Age over 65 and female gender were linked to lower thresholds and discrimination scores (p = 0.037 and p = 0.019). Conclusion: The study highlights PSH and perifocal oedema’s significant effect on olfactory function in OGM patients but finds no link between olfactory impairment and tumour mutations, possibly due to the small sample size. This suggests that age and gender affect olfactory impairment. Additional research with a larger group of participants is needed to explore the impact of OGM driver mutations on olfactory performance.

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Section: Discussionmentioning

confidence: 99%

Correlation of Molecular Status with Preoperative Olfactory Function in Olfactory Groove Meningioma

Podlesek,

Beyer,

Alkhatib

et al. 2024

Cancers

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“…This is in line with previous research finding sex differences in olfaction with relatively small effect sizes 10 . Moreover, previous research has shown that in odour identification, verbal ability 11 , educational attainment 12 , and cognitive factors 13 , 14 play a significant role in modulating both odor discrimination and identification capabilities.…”

Section: Discussionmentioning

confidence: 99%

Development and validation of the MultiScent-20 digital odour identification test using item response theory

Nakanishi,

Brandão,

Freire

et al. 2024

Sci Rep

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Although validated and reliable psychophysical tests of olfactory function are available, an easy-to-use and feasible test has yet to be developed. This study aimed to design a digital odour identification test, evaluate its validity, assess its reliability, establish a normative curve, and explore the impact of demographic factors. The odour identification test was presented with the Multiscent-20, a hand-held, tablet-like digital scent device that features an integrated odour digital delivery system. The identification performance on the 20 odours was assessed using item response theory (IRT). The normative curve was established by administering the test to a large sample of participants (n = 1299). The mean identification score was 17.5 (SD = 2.1). The two-parameter logistic IRT model provided the best fit, revealing variation in item discrimination and difficulty parameters. Educational attainment influenced performance, with primary education associated with lower scores. Additionally, sex was not found to be associated with performance. This study provides initial evidence supporting the validity and reliability of use of the Multiscent-20 as a digital odour identification test. The test’s automation and portability enable the standardized delivery of olfactory stimuli and efficient automatic recording and scoring of responses.

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Behavioral separation of liking and wanting in response to olfactory and visual food cues

Savva,

Dijkman,

Bulik

et al. 2025

Appetite

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Comparable responses to a wide range of olfactory stimulation in women and men

Cited by 5 publications

References 59 publications

Correlation of Molecular Status with Preoperative Olfactory Function in Olfactory Groove Meningioma

Correlation of Molecular Status with Preoperative Olfactory Function in Olfactory Groove Meningioma

Development and validation of the MultiScent-20 digital odour identification test using item response theory

Behavioral separation of liking and wanting in response to olfactory and visual food cues

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