Comparable Studies on Nanoscale Antibacterial Polymer Coatings Based on Different Coating Procedures

Abstract

The antibacterial activity of different antibiotic and metal-free thin polymer coatings was investigated. The films comprised quaternary ammonium compounds (QAC) based on a vinyl benzyl chloride (VBC) building block. Two monomeric QAC of different alkyl chain lengths were prepared, and then polymerized by two different polymerization processes to apply them onto Ti surfaces. At first, the polymeric layer was generated directly on the surface by atom transfer radical polymerization (ATRP). For comparison purposes, in a classical route a copolymerization of the QAC-containing monomers with a metal adhesion mediating phosphonate (VBPOH) monomers was carried out and the Ti surfaces were coated via drop coating. The different coatings were characterized by X-ray photoelectron spectroscopy (XPS) illustrating a thickness in the nanomolecular range. The cytocompatibility in vitro was confirmed by both live/dead and WST-1 assay. The antimicrobial activity was evaluated by two different assays (CFU and BTG, resp.,), showing for both coating processes similar results to kill bacteria on contact. These antibacterial coatings present a simple method to protect metallic devices against microbial contamination.

Carbon Nanotube Coatings’ Role in Transparency, Mechanical Hardness, and Wetting Angle Increase

“…Indeed, it should be remarked that other approaches can be applied to form novel coatings in order to protect materials from corrosion, bacterial activity, and solvent impact, etc. Experiments and mathematical models have been shown in recently published papers [34][35][36][37][38][39][40][41][42][43] and have demonstrated their various advantages. However, the LOD technique has certain unique advantage that allows treatment of all types of the materials, such as inorganic crystals, semiconductors, metals, and some high-temperature polyimide structures, etc.…”

Antibacterial Nanostructured Coatings

“…The original articles include studies on the potential applications of the investigated antibacterial nanostructures and examine different uses, such as devices in the healthcare sector [10], suture materials [11], food packaging films [12], water treatment membranes [13], titanium-based alloys for medical implants [14], and tissue engineering scaffolds [15].…”

“…Their coatings showed good substrate adhesion, cytocompatibility under in vitro conditions, and good antimicrobial activity depending on the length of the alkyl chain of the quaternary ammonium compounds. Possible applications include equipment of metallic devices used in healthcare and medical implants [10]. Basov et al found that, after the application of the freeze/thaw method, the antibacterial activity of suture materials with Ag nanoparticles (AgNPs) was significantly higher than before their treatment with cyclic freezing.…”