Comparación de la función de Framingham original y la calibrada del REGICOR en la predicción del riesgo coronario poblacional

Ramos, Rafael; Solanas, Pascual; Cordón, Ferrán; Rohlfs, Izabella; Elosúa, Roberto; Sala, Joan; Masiá, Rafael; Faixedas, María Teresa; Marrugat, Jaume

doi:10.1016/s0025-7753(03)74007-x

Cited by 75 publications

(10 citation statements)

References 28 publications

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“…To estimate the CVD risk we used the REGICOR scale. This scale is the most recommended for primary prevention of coronary heart disease in Spain because other methods such as the SCORE or Framingham scales overestimate the individual’s CVD risk [34]. …”

Section: Discussionmentioning

confidence: 99%

Effectiveness of a physical activity program on cardiovascular disease risk in adult primary health-care users: the “Pas-a-Pas” community intervention trial

et al. 2017

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BackgroundPhysical activity is a major, modifiable, risk factor for cardiovascular disease (CVD) that contributes to the prevention and management of CVD.The aim of this study was to assess the short- and medium-term effectiveness of 9 months of a supervised physical activity program, including sociocultural activities, on CVD risk in adults.MethodsMulticentered, randomized, controlled community intervention involving 364 patients in four primary care centers. The participants were randomly assigned to a Control Group (CG = 104) or Intervention Group (IG = 260); mean age 65.19 years; 76.8% women. The intervention consisted of 120 min/week walking (396 METs/min/week) and sociocultural gathering once a month. Clinical history, physical activity, dietary intake, CVD risk factors (smoking, systolic and diastolic blood pressure, weight, waist circumference, BMI, total cholesterol, LDL- and HDL-cholesterol, triglycerides, glycosylated hemoglobin and glucose) and global CVD risk were assessed at baseline and at the end of the intervention and multivariate models were applied to the data. Incidence of adverse cardiovascular events and continued adherence to the physical activity were assessed 2 years after intervention.ResultsAt the end of the intervention period, in the IG relative to the CG group, there was a significant increase in physical activity (774.81 METs/min/week), a significant change during the intervention period in systolic blood pressure (−6.63 mmHg), total cholesterol (−10.12 mg/dL) and LDL-cholesterol (−9.05 mg/dL) even after adjustment for potential confounders. At 2 years after the intervention, in the IG, compared with the CG, tthe incidence of adverse cardiovascular events was significantly lower (2.5% vs. 10.5%) and the adherence to regular physical activity was higher (72.8% vs 27.2%) in IG compared to CG.ConclusionsThis community-based physical activity program improved cardiovascular health in the short- as well as medium-term, and promoted regular physical activity in the medium-term in older Spanish adults.Trials registration Clinicaltrials.gov ID NCT02767739. Trial registered on May 5th, 2016. Retrospectively registered

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Section: Discussionmentioning

confidence: 99%

Effectiveness of a physical activity program on cardiovascular disease risk in adult primary health-care users: the “Pas-a-Pas” community intervention trial

et al. 2017

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“…For example, even in regions of high CHD incidence, the low cost effectiveness of statin use in primary prevention makes it difficult for public health services to assume this expense. [21][22][23] Primary prevention in Spain, a country of low CHD incidence (eg, half to one-third the incidence in UK), 1 is even less cost effective. The effectiveness and safety of long-term primary prevention with statins remains uncertain, at least in patients with low-to-moderate coronary risk.…”

Section: Discussionmentioning

confidence: 99%

Validity of an adaptation of the Framingham cardiovascular risk function: the VERIFICA study

Marrugat¹,

Subirana²,

Comín

et al. 2007

Journal of Epidemiology & Community Health

273

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“…Therefore, a validated methodology to adapt the Framingham algorithm to each specific country was developed [15]. Currently, in Spain, apart from the SCORE function, there is another function to estimate the presence of high CV risk: the Framingham-REgistre GIroní del COR (REGICOR) calibrated function [16]. The VERIFICA study (Validation of the Adapted Framingham Individual Coronary Incident Risk Algorithm) demonstrated the reliability and precision of the REGICOR adaptation in Spain [17].…”

Section: Introductionmentioning

confidence: 99%

SCORE and REGICOR function charts underestimate the cardiovascular risk in Spanish patients with rheumatoid arthritis

et al. 2013

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IntroductionOur objective was to determine which one of the two function charts available in Spain to calculate cardiovascular (CV) risk, Systematic COronary Risk Evaluation (SCORE) or Framingham-REgistre GIroní del COR (REGICOR), should be used in patients with rheumatoid arthritis (RA).MethodsA series of RA patients seen over a one-year period without history of CV events were assessed. SCORE, REGICOR, modified (m)SCORE and mREGICOR according to the European League Against Rheumatism (EULAR) recommendations were applied. Carotid ultrasonography (US) was performed. Carotid intima-media thickness (cIMT) > 0.90 mm and/or carotid plaques were used as the gold standard test for severe subclinical atherosclerosis and high CV risk (US+). The area under the receiver operating curves (AUC) for the predicted risk for mSCORE and mREGICOR were calculated according to the presence of severe carotid US findings (US+).ResultsWe included 370 patients (80% women; mean age 58.9 ± 13.7 years); 36% had disease duration of 10 years or more; rheumatoid factor (RF) and/or anticyclic citrullinated peptide (anti-CCP) were positive in 68%; and 17% had extra-articular manifestations. The EULAR multiplier factor was used in 122 (33%) of the patients. The mSCORE was 2.16 ± 2.49% and the mREGICOR 4.36 ± 3.46%. Regarding US results, 196 (53%) patients were US+. The AUC mSCORE was 0.798 (CI 95%: 0.752 to 0.844) and AUC mREGICOR 0.741 (95% CI; 0.691 to 0.792). However, mSCORE and mREGICOR failed to identify 88% and 91% of US+ patients. More than 50% of patients with mSCORE ≥1% or mREGICOR >1% were US+.ConclusionsNeither of these two function charts was useful in estimating CV risk in Spanish RA patients.

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Comparación de la función de Framingham original y la calibrada del REGICOR en la predicción del riesgo coronario poblacional

Cited by 75 publications

References 28 publications

Effectiveness of a physical activity program on cardiovascular disease risk in adult primary health-care users: the “Pas-a-Pas” community intervention trial

Effectiveness of a physical activity program on cardiovascular disease risk in adult primary health-care users: the “Pas-a-Pas” community intervention trial

Validity of an adaptation of the Framingham cardiovascular risk function: the VERIFICA study

SCORE and REGICOR function charts underestimate the cardiovascular risk in Spanish patients with rheumatoid arthritis

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