Comparaison des issues de transferts d’embryons congelés au stade blastocyste selon la technique de congélation et le type de préparation endométriale

Pouget, O.; Scalici, E.; Hoa-Ferrieres, Alice; Deutsch-Bringer, Sophie; Gala, Anna; Déchaud, H.; Hamamah, S.

doi:10.1016/j.gyobfe.2015.01.012

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…The first human pregnancy (twins) from a previously cryopreserved oocyte was reported in 1986 [1]. With improved techniques of cryopreservation (i.e., slowfreeze to ultra-rapid vitrification) there have been tremendous improvement in oocyte survival and clinical pregnancy rates [2,3]. In 2013 the American Society for Reproductive Medicine (ASRM) removed the "experimental" label associated with OC.…”

Section: Introductionmentioning

confidence: 99%

Oocyte cryopreservation review: outcomes of medical oocyte cryopreservation and planned oocyte cryopreservation

Walker

Lanes

Ginsburg

2022

Reprod Biol Endocrinol

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Background The utilization of oocyte cryopreservation (OC) has become popularized with increasing numbers of reproductive-aged patients desiring to maintain fertility for future family building. OC was initially used for fertility preservation in postmenarchal patients prior to gonadotoxic therapies; however, it is now available to patients to circumvent age-related infertility and other diagnoses associated with early loss of ovarian reserve. The primary aim of this paper is to provide a narrative review of the most recent and robust data on the utilization and outcomes of OC in both patient populations. Summary OC results in similar oocyte yield in patients facing gonadotoxic therapies and patients undergoing planned OC. Available data are insufficient to predict the live birth rates or the number of oocytes needed to result in live birth. However, oocyte yield and live birth rates are best among patients < 37.5 years old or with anti-mullerian hormone levels > 1.995 ng/dL, at the time of oocyte retrieval. There is a high ‘no use’ rate (58.9%) in patients using planned OC with 62.5% returning to use frozen oocytes with a spouse. The utilization rate in medical OC patients is < 10%. There is currently no data on the effects of BMI, smoking, or ethnicity on planned OC outcomes. Conclusion It is too early to draw any final conclusions on outcomes of OC in medical OC and planned OC; however, preliminary data supports that utilization of OC in both groups result in preservation of fertility and subsequent live births in patients who return to use their cryopreserved eggs. Higher oocyte yield, with fewer ovarian stimulation cycles, and higher live birth rates are seen in patients who seek OC at younger ages, reinforcing the importance of age on fertility preservation. More studies are needed in medical OC and planned OC to help guide counseling and decision-making in patients seeking these services.

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Section: Introductionmentioning

confidence: 99%

Oocyte cryopreservation review: outcomes of medical oocyte cryopreservation and planned oocyte cryopreservation

Walker

Lanes

Ginsburg

2022

Reprod Biol Endocrinol

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“…The reasons may be that, for example, the equipment is already in place in many clinics, the method is not very operator-demanding, and the results for the developmental stages mentioned are reasonably good. With vitrification, however, much higher survival rates can be obtained [3,4].…”

Section: Introductionmentioning

confidence: 99%

Clinical evaluation of two formulations of slow-freezing solutions for cleavage stage embryos

Jin

et al. 2016

J Assist Reprod Genet

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Purpose The aim was to investigate if improved survival rates could be achieved using a new formulation of solutions for slow freezing of human cleavage stage embryos. Methods The evaluation was divided into two parts. The first part was a retrospective analysis of results obtained after freezing and thawing of day 3 embryos from 400 women using an old formulation of cryopreservation solutions compared to results from 108 women for which cryopreservation had been performed using new compositions of solutions. The second part was prospective, adding cycles until similar numbers of patients had been included in both groups. In total, 2274 embryos from 897 patients were thawed using the old formulation of solutions while 1273 embryos from 542 patients were frozen and thawed using the new solutions. The primary endpoint was survival rate. Results With the new solutions, the survival rate increased from 82.1 to 94.4 % and the complete embryo survival rate increased from 54.9 to 81.3 %. The implantation rate, clinical pregnancy rate per embryo transfer, and per cycle were 28.2, 45.2, and 43.7 %, respectively, using the old formulations of cryosolutions. With the new solutions, the results reached 33.7, 54.1, and 54.1 %, respectively. All differences in results were statistically significant. The number of cancelled embryo transfers due to no survived embryos was 18 with the old solutions and 0 using the new solutions.Conclusion With the new composition of solutions for slow freezing and thawing of embryos, significantly improved results were obtained. Additionally, the number of cancelled embryo transfers was reduced.

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“…[6] found no statistically significant difference between the natural cycles and cycles of hormone replacement treatment in terms of live birth rates or clinical pregnancy rates. Additionally, neither the clinical pregnancy rates nor the live birth rates between the NC and OC nor the NC and GAC differed [7,8] . It has also been demonstrated by several meta-analyses and RCT trials that the best of these four regimens for FET-undergoing women is still debatable [9–11] .…”

Section: Introductionmentioning

confidence: 99%

Pregnancy outcomes of four different cycle protocols for frozen embryo transfer: a large retrospective cohort study

Qian

Wan

et al. 2022

Reproductive and Developmental Medicine

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Objective: To evaluate the pregnancy outcomes of the four endometrial preparation protocols for people undergoing frozenthawed embryo transfer (FET), including natural cycle (NC), hormone replacement therapy cycle (HRT), gonadotropin-releasing hormone agonist artificial cycle (GAC), and ovarian stimulation cycle (OC).Methods: This retrospective cohort study enrolled 10,333 cycles of frozen embryo transfer performed at Xinan Gynecological Hospital in Sichuan, China, from January 2018 to December 2018. The patient's baseline characteristics and pregnancy outcomes were extracted from the medical record system. Pregnancy outcomes were compared among the four groups and multiple logistic regression models were used to adjust for the confounding factors.Results: After adjusting for covariates, multiple logistic regression analysis showed no statistical significance in pregnancy outcomes in the HRT group, GAC group, and OC group compared to the NC group in the entire population. The adjusted odds ratio of live birth was 0.976 (95% confidence interval [CI] 0.837-1.138) for the HRT group, 0.959 (95% confidence interval 0.797-1.152) for the GAC group, and 0.909 (95% confidence interval 0.763-1.083) for the OC group.Conclusions: The natural protocol had comparable pregnancy outcomes compared to the other three endometrial preparation protocols in the overall FET population. More high-quality prospective randomized controlled trials are required to assess the efficacy of the four protocols and explore the optimal one.

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Comparaison des issues de transferts d’embryons congelés au stade blastocyste selon la technique de congélation et le type de préparation endométriale

Cited by 6 publications

References 32 publications

Oocyte cryopreservation review: outcomes of medical oocyte cryopreservation and planned oocyte cryopreservation

Oocyte cryopreservation review: outcomes of medical oocyte cryopreservation and planned oocyte cryopreservation

Clinical evaluation of two formulations of slow-freezing solutions for cleavage stage embryos

Pregnancy outcomes of four different cycle protocols for frozen embryo transfer: a large retrospective cohort study

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