Comparative Activity of 29 Known Anthelmintics under Standardized Drug-Diet and Gavage Medication Regimens against Four Helminth Species in Mice

Chemistry and biological activity of thiazolidinones

“…Electron-donating substituents have been shown to cause a hypsochromic shift while electron-accepting substituents cause a bathochromic shift of this band. The characteristic bands in the region 230-260 nm in the spectra of 2-(phenylimino)-3-methyl-5-arylidenethiazolidin-4-ones (285) undergo a bathochromic shift on the introduction of various types of substituents into the phenyl ring present at position 5 and also in hydroxyl-containing solvents. The UV spectra of 283 in dioxane are of the same nature to a considerable degree as that of the spectra of 285. In hydroxyl solvents (methanol, 70% aqueous dioxane) the spectra of 283 and 285 differ from each other to some degree, and this difference increases with the increase in the polarity of the solvents.…”

The response of nematodes in vivo and in vitro to some anthelmintics

“…Although a wide variety of methods have been used to screen for anthelmintics, Brody and Elward (1971) attempted to standardise results by comparison of anthelmintics administered in the diet and by gavage to mice infected with Nematospiroides dubius and Hymenolepis nana. It is clear from their data that oral (gavage) administration of novel compounds for screening was not satisfactory if N. dubius was used, as several benzimidazoles were not active, but that dietary administration of compounds provided a possible screen.…”