Comparative activity of silver-based antimicrobial composites for urinary catheters

Thokala, Nikhil; Kealey, Carmel; Kennedy, James E.; Brady, Damien; Farrell, Jay A.

doi:10.1016/j.ijantimicag.2018.03.015

Cited by 12 publications

(8 citation statements)

References 17 publications

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“…This is extremely important for the patient’s comfort after insertion by reducing pain, one of the first key factors in developing new materials for using as stents. However, previous studies also show that DLC coatings do not exhibit any antibacterial activity, and consequently, to achieve this performance, an antibacterial agent should be added. , Because of the broad spectrum of antibacterial activity of silver (Ag) and the low incidence to induce bacterial resistance, − it has been used extensively as an antimicrobial agent. To enhance the antibacterial performance of silver, some studies have reported that the addition of a metal nobler than silver, such as platinum or gold, could potentially improve the formation of Ag ions through galvanic action. − …”

Section: Introductionmentioning

confidence: 99%

Antibacterial Effects of Bimetallic Clusters Incorporated in Amorphous Carbon for Stent Application

Carvalho

Dias

Henriques

et al. 2020

ACS Appl. Mater. Interfaces

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The purpose of this work is the development of Ag/a:C and Ag–Au/a:C coatings for ureteral stents, to provide them with antimicrobial characteristics. Silver was selected because of its well-known antibacterial properties, while gold was included to assess its capacity to accelerate the silver ion release forming a galvanic couple between Au and Ag. Thus, the metallic (Ag) and bimetallic clusters (Ag–Au) were produced by three different configurations: (i) unbalanced magnetron sputtering (conventional sputtering), (ii) plasma gas condensation process, and by (iii) a combination between both previous approaches. Coatings with Ag–Au bimetallic clusters were characterized by transmission electron microscopy (TEM) in order to study the arrangement (alloy, core–shell, and galvanic couple) of these particles in the carbon matrix. Inductively coupled plasma optical emission spectroscopy (ICP–OES) was used to quantify the Ag ions released through artificial urine from the different coatings deposited on thermoplastic polyurethane tape (one of the materials used in the manufacture of the ureteral stent ). Then, the antibacterial and cytotoxicity properties of Ag and Ag–Au/a:C coatings were evaluated. TEM shows that a biphasic structure was not detected, thus not allowing to anticipate the establishment of a galvanic couple. The ICP–OES results demonstrate that the silver ionization is mainly a function of the amount of silver incorporated in the amorphous carbon (a:C) matrix, and the formation of a bimetallic alloy has a detrimental effect on release of the silver ions. The antibacterial activity was regulated by the silver ionization mechanisms because the coatings with higher Ag release had a higher antibacterial activity.

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Section: Introductionmentioning

confidence: 99%

Antibacterial Effects of Bimetallic Clusters Incorporated in Amorphous Carbon for Stent Application

Carvalho

Dias

Henriques

et al. 2020

ACS Appl. Mater. Interfaces

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“…The prevention of biofilm formation and bacterial adhesion on various materials is subject to research [16,17]. A wide selection of additives (often toxic), providing permanent protection against the adverse effects of microorganisms, exists for paints and coatings [18][19][20]. Antibiotics are among the most frequently used agents for this purpose.…”

Section: Introductionmentioning

confidence: 99%

Environmentally Friendly Water-Based Self-Crosslinking Acrylate Dispersion Containing Magnesium Nanoparticles and Their Films Exhibiting Antimicrobial Properties

et al. 2020

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A water-based polymeric acrylate dispersion (latex) containing MgO nanoparticles, which had been added at a concentration of 1.5% (with respect to the monomers) during the preparation procedure, was investigated as an environmentally friendly binder for sanitary interior paints. The properties of this new latex were compared to those of a reference system free of the magnesium nanoparticles, synthesized by the same route, i.e., by semi-continuous emulsion polymerization. Tests were made in order to ascertain the mechanical and chemical properties, flash corrosion resistance and antimicrobial effect of the latex films. The results revealed that the new latex containing magnesium nanoparticles provided solvent-resistant coating films having pronounced antimicrobial activity against all the tested bacterial and fungal strains. The desirable antimicrobial properties can be ascribed to the sharp-edged character of magnesium nanoparticles, the peroxidation of lipids and the formation of reactive oxygen species. Moreover, no flash corrosion was formed beneath coating films containing magnesium nanoparticles, which can be attributed to the alkaline action due to the dissolution of a fraction of MgO in latex medium. The results of all of the tests provided evidence of the superiority of the polymeric dispersion with the magnesium nanoparticles to the reference system containing no nanoparticles.

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“…36 Silver could be applied in several forms for medical device coating, such as the free dissolved ions, the compound with metals (palladium/gold) or polymers, and the silver nanoparticles (AgNPs). 38 Typically, coating with pure silver (Ag-alloy) doesn't have enough bacteriocidal efficacy and decays rapidly, which is attributed to the poor solubility of silver. Moreover, silver is sensitive to oxidation in aqueous environments, which leads to fast ion releases that is highly biocidal in nature.…”

Section: Silver Nanoparticlesmentioning

confidence: 99%

Novel surface biochemical modifications of urinary catheters to prevent catheter‐associated urinary tract infections

Safari,

Mohabatkar,

Behbahani

2024

J Biomed Mater Res

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More than 70% of hospital‐acquired urinary tract infections are related to urinary catheters, which are commonly used for the treatment of about 20% of hospitalized patients. Urinary catheters are used to drain the bladder if there is an obstruction in the tube that carries urine out of the bladder (urethra). During catheter‐associated urinary tract infections, microorganisms rise up in the urinary tract and reach the bladder, and cause infections. Various materials are used to fabricate urinary catheters such as silicone, polyurethane, and latex. These materials allow bacteria and fungi to develop colonies on their inner and outer surfaces, leading to bacteriuria or other infections. Urinary catheters could be modified to exert antibacterial and antifungal effects. Although so many research have been conducted over the past years on the fabrication of antibacterial and antifouling catheters, an ideal catheter needs to be developed for long‐term catheterization of more than a month. In this review, we are going to introduce the recent advances in fabricating antibacterial materials to prevent catheter‐associated urinary tract infections, such as nanoparticles, antibiotics, chemical compounds, antimicrobial peptides, bacteriophages, and plant extracts.

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Comparative activity of silver-based antimicrobial composites for urinary catheters

Cited by 12 publications

References 17 publications

Antibacterial Effects of Bimetallic Clusters Incorporated in Amorphous Carbon for Stent Application

Antibacterial Effects of Bimetallic Clusters Incorporated in Amorphous Carbon for Stent Application

Environmentally Friendly Water-Based Self-Crosslinking Acrylate Dispersion Containing Magnesium Nanoparticles and Their Films Exhibiting Antimicrobial Properties

Novel surface biochemical modifications of urinary catheters to prevent catheter‐associated urinary tract infections

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