Comparative acute lung inflammation induced by atmospheric PM and size-fractionated tire particles

Mantecca, Paride; Farina, Francesca; Moschini, Elisa; Gallinotti, Daniele; Gualtieri, Maurizio; Rohr, Annette; Sancini, Giulio; Palestini, Paola; Camatini, Marina

doi:10.1016/j.toxlet.2010.07.002

Cited by 104 publications

(80 citation statements)

References 64 publications

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“…The organic extracts from tire wear induced a dose-dependent increase in cell mortality and DNA damage. The role of tire wear particles in an inflammatory response was also studied Lindbom et al, 2007;Mantecca et al, 2010;Karlsson et al, 2006). The results showed that wear particles from studded tires and pavement can induce the release of proinflammatory cytokines from macrophages and human lung epithelial cells Karlsson et al, 2006).…”

Section: Health Effects and Risk Assessmentmentioning

confidence: 99%

“…This study showed the increase of proteins associated with an inflammatory response, while proteins involved in cellular functions and glycolysis were reduced. Only a few in vivo studies have reported the toxicity of tire wear particles (Gottipolu et al, 2008;Mantecca et al, 2009;Mantecca et al, 2010). The study of Gottipolu et al (2008) showed that rats exposed to respirable (<5.0 µm) tire wear particles by intratracheal instillation developed acute pulmonary inflammation.…”

Section: Health Effects and Risk Assessmentmentioning

confidence: 99%

“…In a second study with a similar setup Mantecca et al (2010) compared the acute inflammatory responses of tire particles from two size fractions 3 hr after exposure to elucidate the time course of the lung inflammatory process. While Mantecca et al (2009) showed that both size fractions induced an inflammatory response, which was still present 24 hr after instillation, the time-course study revealed that coarse particles do not induce an early recruitment of neutrophils (Mantecca et al, 2010).…”

Section: Health Effects and Risk Assessmentmentioning

confidence: 99%

“…Some studies have not only examined the toxicity of wear particles but included the relative toxicity of different sources (Karlsson et al, 2006;Karlsson et al, 2008;Lindbom et al, 2006;Lindbom et al, 2007;Mantecca et al, 2010). Tire/road wear particles were able to cause DNA damage of the same magnitude as particles collected from wood combustion and an urban street (Karlsson et al, 2006).…”

Section: Health Effects and Risk Assessmentmentioning

confidence: 99%

See 3 more Smart Citations

The Policy Relevance of Wear Emissions from Road Transport, Now and in the Future—An International Workshop Report and Consensus Statement

Gon

Gerlofs-Nijland

Gehrig

et al. 2012

Journal of the Air & Waste Management Association

181

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Road transport emissions are a major contributor to ambient particulate matter concentrations and have been associated with adverse health effects. Therefore, these emissions are targeted through increasingly stringent European emission standards. These policies succeed in reducing exhaust emissions, but do not address "nonexhaust" emissions from brake wear, tire wear, road wear, and suspension in air of road dust.Is this a problem? To what extent do nonexhaust emissions contribute to ambient concentrations of PM 10 or PM 2.5 ? In the near future, wear emissions may dominate the remaining traffic-related PM 10 emissions in Europe, mostly due to the steep decrease in PM exhaust emissions. This underlines the need to determine the relevance of the wear emissions as a contribution to the existing ambient PM concentrations, and the need to assess the health risks related to wear particles, which has not yet received much attention. During a workshop in 2011, available knowledge was reported and evaluated so as to draw conclusions on the relevance of traffic-related wear emissions for air quality policy development. On the basis of available evidence, which is briefly presented in this paper, it was concluded that nonexhaust emissions and in particular suspension in air of road dust are major contributors to exceedances at street locations of the PM 10 air quality standards in various European cities. Furthermore, wear-related PM emissions that contain high concentrations of metals may (despite their limited contribution to the mass of nonexhaust emissions) cause significant health risks for the population, especially those living near intensely trafficked locations. To quantify the existing health risks, targeted research is required on wear emissions, their dispersion in urban areas, population exposure, and its effects on health. Such information will be crucial for environmental policymakers as an input for discussions on the need to develop control strategies.Implications: Road transport particulate matter (PM) emissions are associated with adverse health effects. Stringent policies succeed in reducing the exhaust PM emissions, but do not address "nonexhaust" emissions from brake wear, tire wear, road wear, and suspension in air of road dust. In the near future the nonexhaust emissions will dominate the road transport PM emissions. Based on the limited available evidence, it is argued that dedicated research is required on nonexhaust emissions and dispersion to urban areas from both an air quality and a public health perspective. The implicated message to regulators and policy makers is that road transport emissions continue to be an issue for health and air quality, despite the encouraging rapid decrease of tailpipe exhaust emissions.

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Section: Health Effects and Risk Assessmentmentioning

confidence: 99%

Section: Health Effects and Risk Assessmentmentioning

confidence: 99%

Section: Health Effects and Risk Assessmentmentioning

confidence: 99%

Section: Health Effects and Risk Assessmentmentioning

confidence: 99%

See 2 more Smart Citations

The Policy Relevance of Wear Emissions from Road Transport, Now and in the Future—An International Workshop Report and Consensus Statement

Gon

Gerlofs-Nijland

Gehrig

et al. 2012

Journal of the Air & Waste Management Association

181

View full text Add to dashboard Cite

show abstract

“…Up to now, an association between PM 10 exposure and histological diagnosis, as we did in this study, has never been demonstrated. Only animal studies and some human studies, including only low numbers of subjects, attempted to link PM with airway neutrophilia in healthy adults (20,21). In most cases, the investigators used very high, acute exposures to PM, whereas we investigated the effect of real life levels in Flanders, Belgium, over several years.…”

Section: Discussionmentioning

confidence: 99%

Lymphocytic Bronchiolitis After Lung Transplantation Is Associated With Daily Changes in Air Pollution

Verleden

Scheers

Nawrot

et al. 2012

American Journal of Transplantation

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Air Pollution and Other Environmental Modulators of Cardiac Function

Gorr

Falvo

Wold

2017

Comprehensive Physiology

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Cardiovascular disease (CVD) is the leading cause of death in developed regions and a worldwide health concern. Multiple external causes of CVD are well known, including obesity, diabetes, hyperlipidemia, age, and sedentary behavior. Air pollution has been linked with the development of CVD for decades, though the mechanistic characterization remains unknown. In this comprehensive review, we detail the background and epidemiology of the effects of air pollution and other environmental modulators on the heart, including both short- and long-term consequences. Then, we provide the experimental data and current hypotheses of how pollution is able to cause the CVD, and how exposure to pollutants is exacerbated in sensitive states. Published 2017. Compr Physiol 7:1479-1495, 2017.

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Comparative acute lung inflammation induced by atmospheric PM and size-fractionated tire particles

Cited by 104 publications

References 64 publications

The Policy Relevance of Wear Emissions from Road Transport, Now and in the Future—An International Workshop Report and Consensus Statement

The Policy Relevance of Wear Emissions from Road Transport, Now and in the Future—An International Workshop Report and Consensus Statement

Lymphocytic Bronchiolitis After Lung Transplantation Is Associated With Daily Changes in Air Pollution

Air Pollution and Other Environmental Modulators of Cardiac Function

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