Comparative Analysis of Compatibility Influence on Invigorating Blood Circulation for Combined Use of Panax Notoginseng Saponins and Aspirin Using Metabolomics Approach

Abstract

The combined use of Panax notoginseng saponins (PNS)–based drugs and aspirin (ASA) to combat vascular diseases has achieved good clinical results. In this study, the superior efficacy was observed via the combined use of PNS and ASA on acute blood stasis rats, and untargeted metabolomics was performed to holistically investigate the therapeutic effects of coupling application and its regulatory mechanisms. The combined use of PNS and ASA exhibited better improvement effects when reducing the evaluated hemorheological indicators (whole blood viscosity, plasma viscosity, platelet aggregation, and fibrinogen content) in the blood stasis rats vs. single use of PNS or ASA at the same dose. The combined use of both drugs was the most effective application method, as shown by the relative distance in partial least-squares discriminant analysis score plots. Twelve metabolites associated with blood stasis were screened as potential biomarkers and were mainly involved in amino acid metabolism, lipid metabolism, and energy metabolism. After coherently treated with PNS and ASA, the altered metabolites could be partially adjusted to be closer to normal levels than single use. The collective results revealed that PNS could cooperate with ASA to treat blood stasis and provided a scientific explanation for the superior efficacy of their combined use.

Intracavitary physiotherapy combined with acupuncture mediated AMPK/mTOR signalling to improve endometrial receptivity in patients with thin endometrium

“…In TCM syndrome differentiation, kidney deficiency and blood stasis are the most common types of thin endometrium.a study had confirmed through proteomics that proteomic changes of Coronary heart disease with kidney deficiency and blood stasis are closely related to abnormal energy metabolism [19].so there is abnormal energy metabolism in thin endometrial tissue.Zhang [20]concluded that kidney deficiency and ageing were closely related to lipid metabolism and energy metabolism through the analysis of UHPLC QTOF/MS-based metabonomics research methods. Sun [21] used the combined method of PNS and ASA to screen 12 metabolites related to blood stasis as potential biomarkers, mainly involving amino acid metabolism, lipid metabolism and energy metabolism. He [22]confirmed that acupuncture can improve liver energy metabolism in rats.…”

Pharmacokinetic and pharmacodynamic herb–drug interactions of common over‐the‐counter pain medications

“…Panax notoginseng saponin‐based drugs are often prescribed together with aspirin for the prevention of atherosclerosis. Sun et al found that P. notoginseng saponin‐based drugs could inhibit the hydrolysis of aspirin during intestinal absorption, leading to an increase in its bioavailability (Sun et al, 2018,b) and the synergistic pharmacodynamic effect of the two was confirmed in a blood stasis rat model (Sun et al, 2021).…”

The effects and underlying mechanisms of medicine and food homologous flowers on the prevention and treatment of related diseases

“…By using the paper diffusion method, it can be seen that they have antibacterial activity against Escherichia coli , Staphylococcus aureus , and Pseudomonas aeruginosa . Lonicera essential oil may be a new potential source for natural antibacterial agents in the field of medicine (Sun et al, 2021). FLJ also has psychotherapeutic effects.…”

“…P. notoginseng inhibits autophagy through the target of the rapamycin signaling pathway and other autophagy pathways, thereby protecting the brain function of rats from traumatic brain injury (Shi et al, 2021). In addition, it also has the effect of reducing cytotoxicity, which can be combined with other medicines for treatment (Liu et al, 2021; Sun et al, 2021; Wang, Fan, et al, 2021).…”