Comparative analysis of cytokine patterns in immunological, infectious, and oncological neurological disorders

Weller, Michael; Stevens, Andreas; Sommer, Norbert; Melms, Arthur; Dichgans, J.; Wiethölter, H.

doi:10.1016/0022-510x(91)90313-v

Cited by 82 publications

(67 citation statements)

References 41 publications

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“…IL-6 has been detected both in established human glioma cell lines (31,34,62) and in tumor cyst fluids in patients harboring malignant gliomas (64,91). It is a pleiotropic cytokine with reported functions including stimulating glioma growth (60,92) as well as shifting antiglioma immune responses to T helper 2 (Th2) pathways that are less effective in eradicating tumors than cell-mediated (Th1) responses (31,93).…”

Section: Discussionmentioning

confidence: 98%

Changes in the Immunologic Phenotype of Human Malignant Glioma Cells after Passaging in Vitro

Anderson

Elder

Brown

et al. 2002

Clinical Immunology

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Section: Discussionmentioning

confidence: 98%

Changes in the Immunologic Phenotype of Human Malignant Glioma Cells after Passaging in Vitro

Anderson

Elder

Brown

et al. 2002

Clinical Immunology

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“…The release of cytokines by malignant glioma cells has been associated with glioma progression (Gillespie, 1996); for example, IL-6 has been detected in tumour cysts and cerebrospinal fluids in patients harbouring malignant gliomas (Weller et al, 1991;Frei et al, 1992).…”

mentioning

confidence: 99%

Substance P activates responses correlated with tumour growth in human glioma cell lines bearing tachykinin NK1 receptors

et al. 1998

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SummaryThe neuropeptide substance P (SP), by stimulating tachykinin NK 1 receptors (NK 1 R), triggers a number of biological responses in human glioma cells which are potentially relevant for tumour growth. First, radioligand binding studies demonstrated the presence of tachykinin NK 1 R on SNB-19, DBTRG-05 MG and U373 MG, but not on U138 MG and MOG-G-GCM human glioma cell lines. Second, application of SP or neurokinin A (NKA) to NK 1 R + glioma cell lines increased the secretion of interleukin 6 (IL-6) and potentiated IL-6 secretion induced by IL-1β. SP also up-regulated the release of transforming growth factor β1 (TGF-β1) by the U373 MG glioma cell line. Third, SP induced new DNA synthesis and enhanced the proliferation rate of NK 1 R + , but not of NK 1 R -glioma cell lines. Also, NKA stimulated the proliferation and cytokine secretion in NK 1 R + glioma cell lines. All the stimulant effects of SP/NKA on NK 1 R + glioma cell lines were completely blocked by a specific tachykinin NK 1 R antagonist, MEN 11467. These data support the potential use of tachykinin NK 1 R antagonist for controlling the proliferative rate of human gliomas.

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“…Tauber et al (56) have demonstrated in vitro that CSF from rabbits infected with bacterial meningitis (pneumococcal or Escherichia coli meningitis) is highly neurotoxic and that the neurotoxicity is mainly based on the presence of TNF-a. High intrathecal levels of TNF-a were also reported for patients with bacterial meningitis (34,58).…”

Section: Bacterial Meningitismentioning

confidence: 92%

CSF Filtration: Scientific and Clinical Update

Heusslein¹,

Rother²,

Trömel³

et al. 1996

Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.

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Comparative analysis of cytokine patterns in immunological, infectious, and oncological neurological disorders

Cited by 82 publications

References 41 publications

Changes in the Immunologic Phenotype of Human Malignant Glioma Cells after Passaging in Vitro

Changes in the Immunologic Phenotype of Human Malignant Glioma Cells after Passaging in Vitro

Substance P activates responses correlated with tumour growth in human glioma cell lines bearing tachykinin NK1 receptors

CSF Filtration: Scientific and Clinical Update

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