Comparative Analysis of Different Local Anesthetic Solutions Available in Market: An In Vitro and Clinical Study

Imran, Eisha; Moeen, Faisal; Abbas, Beenish; Yaqoob, Bakhtawar; Wajahat, Mehreen; Khan, Quratulain; Khurshid, Zohaib

doi:10.1055/s-0041-1727553

Cited by 2 publications

(2 citation statements)

References 43 publications

(66 reference statements)

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“…The highest blood levels are achieved after intercostal nerve block, while subcutaneous administration results in the lowest blood levels. LIDO crosses both the blood-brain and placental barriers, likely via passive diffusion [35][36][37][38][39][40][41][42][43][44][45][46][47][48].…”

Section: Pharmacology and Mechanism Of Actionmentioning

confidence: 99%

A Review of the Lidocaine in the Perioperative Period

Silva,

Mourão,

Vale

2023

JPM

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This review analyzes the controversies surrounding lidocaine (LIDO), a widely recognized local anesthetic, by exploring its multifaceted effects on pain control in the perioperative setting. The article critically analyzes debates about lidocaine’s efficacy, safety, and optimal administration methods. While acknowledging its well-documented analgesic attributes, the text highlights the ongoing controversies in its application. The goal is to provide clinicians with a comprehensive understanding of the current discourse, enabling informed decisions about incorporating lidocaine into perioperative protocols. On the other hand, emphasizes the common uses of lidocaine and its potential role in personalized medicine. It discusses the medication’s versatility, including its application in anesthesia, chronic pain, and cardiovascular diseases. The text recognizes lidocaine’s widespread use in medical practice and its ability to be combined with other drugs, showcasing its adaptability for individualized treatments. Additionally, it explores the incorporation of lidocaine into hyaluronic acid injections and its impact on pharmacokinetics, signaling innovative approaches. The discussion centers on how lidocaine, within the realm of personalized medicine, can offer safer and more comfortable experiences for patients through tailored treatments.

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Section: Pharmacology and Mechanism Of Actionmentioning

confidence: 99%

A Review of the Lidocaine in the Perioperative Period

Silva,

Mourão,

Vale

2023

JPM

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“…Local anesthetic (LA) solutions with epinephrine added to prolong the anesthetic effect have a low pH (3–5) to prevent early oxidation of epinephrine and prolong its shelf life [ 1 2 ]. However, this acidity may result in increased pain (burning sensation) due to the injection and decreased onset of anesthesia [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Anesthetic efficacy of buffered 4% articaine for mandibular first molar infiltration: a crossover clinical trial

Manta,

Dabarakis,

Lillis

et al. 2023

J Dent Anesth Pain Med

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Background The limited studies on the effect of buffering on the clinical efficacy of articaine have reported controversial results. The purpose of this study was to clinically compare the pain of injection, anesthetic success, onset, and duration of pulpal anesthesia of buffered 4% articaine with epinephrine 1:100000 versus a non-buffered 4% articaine with epinephrine 1:100000 formulation for buccal infiltration of the mandibular first molar. Methods Sixty-three volunteers were enrolled in the study. All volunteers received two injections consisting of a single mandibular first molar buccal infiltration with 1.8 ml of 4% articaine with epinephrine 1:100000 and 1.8 ml of 4% articaine with epinephrine 1:100000 buffered with 8.4% sodium bicarbonate. The infiltrations were applied in two separate appointments spaced at least one week apart. After injection of the anesthetic solution at the examined site, the first molar was pulp-tested every 2 min for the next 60 min. Results Successful pulpal anesthesia was recorded in 69.8% of cases using non-buffered articaine solution and 76.2% of cases using buffered articaine solution, with no significant difference between the formulations (P = 0.219). The mean time of anesthesia onset for the volunteers with successful anesthetic outcome in both formulations (n = 43) was 6.6 ± 1.6 min for the non-buffered articaine solution and 4.5 ± 1.6 min for the buffered solution, which differed significantly (P = 0.001). In the same volunteers, the mean duration of pulpal anesthesia was 28.4 ± 7.1 min for non-buffered articaine solution and 30.2 ± 8.5 min for buffered articaine solution, with no significant difference between the formulations (P = 0.231). Considering the pain of injection, regardless of the anesthetic success, the mean values of VAS were 11.3 ± 8.2 mm for the non-buffered articaine solution and 7.8 ±6.5 mm for the buffered articaine solution, which differed significantly (P = 0.001 < 0.05). Conclusion According to the present study, 4% articaine with epinephrine can benefit from buffering and provide better anesthetic behavior, with improved onset and less pain during injection.

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Comparative Analysis of Different Local Anesthetic Solutions Available in Market: An In Vitro and Clinical Study

Cited by 2 publications

References 43 publications

A Review of the Lidocaine in the Perioperative Period

A Review of the Lidocaine in the Perioperative Period

Anesthetic efficacy of buffered 4% articaine for mandibular first molar infiltration: a crossover clinical trial

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