Comparative analysis of essential oils from eight herbal medicines with pungent flavor and cool nature by GC–MS and chemometric resolution methods

Zhao, Chenxi; Zeng, Yingxu; Wan, Ming-Zhu; Li, Rongxi; Liang, Yi‐Zeng; Li, Chengyong; Zeng, Zhongda; Chau, Foo‐Tim

doi:10.1002/jssc.200800484

Cited by 49 publications

(29 citation statements)

References 22 publications

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“…Zhao et al . [31] identified PADE from traditional Chinese medicines of pungent flavor and cool nature by GC-MS. Lin et al . [32] isolated BADE from the volatile components of Eclipta prostrate by GC-MS.…”

Section: Discussionmentioning

confidence: 99%

Biochemical composition and antioxidant capacity of extracts from Podophyllum hexandrum rhizome

Zhou

Yang

et al. 2012

BMC Complement Altern Med

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BackgroundPodophyllum hexandrum Royle (P. hexandrum) is a perennial herb and widely used in clinic. The present study was designed to separate and identify the biochemical composition and antioxidant capacity of extracts from P. hexandrum rhizome.MethodsThe ethyl acetate and ethanol extracts from P. hexandrum rhizome were analyzed by GC-MS (gas chromatography–mass spectrometry), and the antioxidant capacity of the extracts and the components was tested by using the DPPH (2, 2-diphenylpicrylhydrazyl) and FRAP (Ferric reducing/antioxidant power) assays.ResultsThe rhizome extracts had greater antioxidant capacity than the petiole extracts in DPPH and FRAP assays. About 16 kinds of main reactive oxygen components were identified in the extracts. Components of PADE (Phthalic acid, diisobutyl ester), BADE (1,2-Benzenedicarboxylic acid, diisooctyl ester), Polyneuridine, PODD (Podophyllotoxin, deoxy), β-Sitosterol and POD (Podophyllotoxin) showed the antioxidant capacity in some degree. PODD, POD, and Polyneuridine showed stronger antioxidant capacity with the IC50 and FRAP values of 9.61 ± 0.81 and 2923.98 ± 21.89 μM, 9.98 ± 0.24 and 2847.27 ± 14.82 μM, and 13.37 ± 0.35 and 2404.32 ± 36.88 μM, respectively, than the positive control ASA (Ascorbic acid) with the values of 60.78 ± 1.22 and 1267.5 ± 30.24 μM (P < 0.01).ConclusionsPODD, POD, and Polyneuridine are very critical for the antioxidant capacity in the extract of P. hexandrum rhizome. These results provide useful biochemical basis and information for the potential use of this plant.

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Section: Discussionmentioning

confidence: 99%

Biochemical composition and antioxidant capacity of extracts from Podophyllum hexandrum rhizome

Zhou

Yang

et al. 2012

BMC Complement Altern Med

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“…Therefore, to enhance and stabilize the therapeutic efficacy of TCM, many studies have focused on identifying and purifying the biologically active ingredients of the medicinal substances used in TCM 18 . With developments in chemical purification technologies and mass spectrometry, the active ingredients of many TCM substances have been successively purified, and their functions have been determined 20 – 23 . These extracts can be used at lower doses and can provide more specific therapeutic efficacies.…”

Section: Introductionmentioning

confidence: 99%

Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair

et al. 2018

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Corylin, a biologically active agent extracted from Psoralea corylifolia L. (Fabaceae), promotes bone differentiation and inhibits inflammation. Currently, few reports have addressed the biological functions that are regulated by corylin, and to date, no studies have investigated its antitumor activity. In this study, we used cell functional assays to analyze the antitumor activity of corylin in hepatocellular carcinoma (HCC). Furthermore, whole-transcriptome assays were performed to identify the downstream genes that were regulated by corylin, and gain-of-function and loss-of-function experiments were conducted to examine the regulatory roles of the above genes. We found that corylin significantly inhibited the proliferation, migration, and invasion of HCC cells and increased the toxic effects of chemotherapeutic agents against HCC cells. These properties were due to the induction of a long noncoding RNA, RAD51-AS1, which bound to RAD51 mRNA, thereby inhibiting RAD51 protein expression, thus inhibiting the DNA damage repair ability of HCC cells. Animal experiments also showed that a combination treatment with corylin significantly increased the inhibitory effects of the chemotherapeutic agent etoposide (VP16) on tumor growth. These findings indicate that corylin has strong potential as an adjuvant drug in HCC treatment and that corylin can strengthen the therapeutic efficacy of chemotherapy and radiotherapy.

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“…Cannabis oils (Russo, 2011). This terpene is listed as generally recognized as safe (GRAS) in the US, FDA Code of Federal Regulations as a flavoring agent, and can be found in common food items such as fruit juices, soft drinks, baked goods, ice cream, and pudding (Nazaroff and Weschler, 2004;Sun, 2007;Zhao et al, 2009). Limonene is directly absorbed in the gastrointestinal tract of both humans and animals when administered orally and rapidly disperses to different tissues (detectable in serum, liver, lung, kidney, and many other tissues) and quickly undergoes the metabolization processes for hydroxylation and carboxylation.…”

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confidence: 99%

Monoterpenes modulating cytokines - A review

Quintans

Saravanan

Heimfarth

et al. 2019

Food and Chemical Toxicology

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Inflammatory response can be driven by cytokine production and is a pivotal target in the management of inflammatory diseases. Monoterpenes have shown that promising profile as agents which reduce the inflammatory process and also modulate the key chemical mediators of inflammation, such as pro and anti-inflammatory cytokines. The main interest focused on monoterpenes were to develop the analgesic and anti-inflammatory drugs. In this review, we summarized current knowledge on monoterpenes that produce anti-inflammatory effects by modulating the release of cytokines, as well as suggesting that which monoterpenoid molecules may be most effective in the treatment of inflammatory disease. Several different inflammatory markers were evaluated as a target of monoterpenes. The proinflammatory and antiinflammatory cytokines were found TNF-α, IL-1β, IL-2, IL-5, IL-4, IL-6, IL-8, IL-10, IL-12 IL-13, IL-17A, IFNγ, TGF-β1 and IFN-γ. Our review found evidence that NF-κB and MAPK signaling are important pathways for the anti-inflammatory action of monoterpenes. We found 24 monoterpenes that modulate the production of cytokines, which appears to be the major pharmacological mechanism these compounds possess in relation to the attenuation of inflammatory response. Despite the compelling evidence supporting the anti-inflammatory effect of monoterpenes, further studies are necessary to fully explore their potential as anti-inflammatory compounds.

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Comparative analysis of essential oils from eight herbal medicines with pungent flavor and cool nature by GC–MS and chemometric resolution methods

Cited by 49 publications

References 22 publications

Biochemical composition and antioxidant capacity of extracts from Podophyllum hexandrum rhizome

Biochemical composition and antioxidant capacity of extracts from Podophyllum hexandrum rhizome

Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair

Monoterpenes modulating cytokines - A review

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