Comparative analysis of four biomarkers in diagnosing premature rupture of membranes and their correlation with onset of labour

Qualitative Determination of Human Chorionic Gonadotropin in Vaginal Washings for the Early Diagnosis of Premature Rupture of Fetal Membranes

“…Moreover, we achieved specificity rates that were higher than those of many previous studies, which reported specificity rates of 68%, 84%, 86%, for example. [13][14][15] In the present study, the β-hCG-10 and β-hCG-25 tests provided NPVs of 70.4% and 72.9% respectively. These results were better than the NPV of another study that used a bigger cut-off point (100 mUI/mL).…”

“…2 Current studies emphasize research on biochemical agents found at high levels in the amniotic fluid: prolactin, α-fetoprotein, insulin-like growth factor, fetal fibronectin, urea, lactate, placental alpha microglobulin-1, diamine oxidase, human chorionic gonadotropin (hCG), and creatine. [2][3][4]8,9,[11][12][13][14] Most of these tests are not popular because they have high costs and complexity. 2 Out of all biochemical markers studied, we highlight the hCG β subunit (β-hCG).…”

“…Its prevalence ranges from [8][9][10][11][12][13][14][15][16][17][18][19].53% of term pregnancies, and from 2-25% of all pregnancies. Traditionally, the diagnosis of PROM involves vaginal discharge history of amniotic fluid verified at speculum examination with the ferning test in the microscopic exam and the nitrazine test of the vaginal discharge.…”

Vaginal discharge concentrations of β‐human chorionic gonadotropin, creatinine, and urea for the diagnosis of premature rupture of membranes

“…The various methods currently available to diagnose PROM include the nitrazine, pooling, and Fern tests, as well as measurement of vaginal diamino oxidase, prolactin, α‐fetoprotein, insulin‐like growth factor‐binding protein 1, β human chorionic gonadotropin (β‐hCG), fetal fibronectin, and placental 1 α‐macroglobulin . However, ultrasonographic measurement of the amniotic fluid index is unreliable because PROM cannot be differentiated from other causes of oligohydramnios …”

“…Many studies have been conducted on the diagnosis of PROM . Some studies have evaluated β‐hCG because this hormone is secreted from the cervical glands and is present in vaginal discharge .…”