Comparative Analysis of Long Noncoding RNA Expression in Human Hepatocyte Cell Lines and Liver

Burenina, Olga Y.; Zatsepin, Timofei S.; Kim, E F; Метелин, А. В.; Skvortsov, Dmitry A.; Rubtsova, Maria P.; Донцова, О. А.

doi:10.1134/s1607672920040043

Cited by 2 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, lncRNA H19 was found to most closely match normal hepatocyte expression levels in differentiated HepaRG cells with little endogenous expression in the HepG2, Huh7, and undifferentiated HepaRG cells. In contrast, differentiated HepaRGs expressed higher levels of the lncRNA metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) than normal liver samples, HepG2, Huh7, and undifferentiated HepaRG cells 53 …”

Section: Analysis Of Lncrna Expression In Hbv‐infected Cells In Vivo ...mentioning

confidence: 99%

“…However, interpretation of HBV‐induced effects must consider that these cell lines are mostly derived from hepatocarcinomas and already contain altered transcriptomes and proteomes relative to normal hepatocytes. A recent study comparing liver‐specific transcripts and lncRNA profiles between HepG2, Huh7, undifferentiated HepaRG, differentiated HepaRG, and normal liver samples found significant differences in mean gene expression across cell lines, with some transcripts in certain cell lines matching healthy hepatocytes better than others 53 . For example, lncRNA H19 was found to most closely match normal hepatocyte expression levels in differentiated HepaRG cells with little endogenous expression in the HepG2, Huh7, and undifferentiated HepaRG cells.…”

Section: Analysis Of Lncrna Expression In Hbv‐infected Cells In Vivo ...mentioning

confidence: 99%

See 1 more Smart Citation

The interplay of long noncoding RNAs and hepatitis B virus

Sarfaraz

Somarowthu

Bouchard

2022

Journal of Medical Virology

View full text Add to dashboard Cite

Hepatitis B Virus (HBV) infections remain a major global health burden with an estimated 296 million people living with a chronic infection and 884,000 HBV‐related deaths annually. Notably, patients with a chronic hepatitis B (CHB) infection are at a 30‐fold greater risk of developing hepatocellular carcinoma (HCC), the most common type of primary liver cancer, which is the 3rd deadliest cancer worldwide. Several groups have assessed HBV‐related aberrant expression of host‐cell long noncoding RNAs (lncRNAs) and how altered expression of specific lncRNAs affects HBV replication and progression to associated disease states. Given the challenges in establishing effective HBV models and analyzing transcriptomic data, this review focuses on lncRNA expression data primarily collected from clinical patient samples and primary human hepatocytes, with the subsequent mechanism of action analysis in cell lines or other model systems. Ultimately, understanding HBV‐induced lncRNA‐expression dysregulation could lead to new treatments and biomarkers for HBV infection and its associated diseases.

show abstract

Section: Analysis Of Lncrna Expression In Hbv‐infected Cells In Vivo ...mentioning

confidence: 99%

Section: Analysis Of Lncrna Expression In Hbv‐infected Cells In Vivo ...mentioning

confidence: 99%

The interplay of long noncoding RNAs and hepatitis B virus

Sarfaraz

Somarowthu

Bouchard

2022

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…In recent years, there has been a steady increase in the number of newly created, useful chemicals derived from natural sources. The flavonoid family is the most well recognized (Alharbi, Almalki, et al, 2022; Bresnahan et al, 2020; Burenina et al, 2020; Fakhri et al, 2020).…”

Section: Clinical Studiesmentioning

confidence: 99%

The therapeutic role of nutraceuticals targeting the Nrf2/ HO ‐1 signaling pathway in liver cancer

Alharbi

Almalki

Albratty

et al. 2022

Journal of Food Biochemistry

View full text Add to dashboard Cite

Liver cancer (L.C.) is the most common cause of cancer death in the United States and the fifth most common globally. The overexpression of nuclear factor E2 related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) caused by oxidative stress has been associated with tumor growth, aggressiveness, treatment resistance, and poor prognosis. Nutraceuticals that inhibit Nrf2/HO-1 signaling may become the most effective strategy to treat liver cancer. Phytochemicals found in fruits and vegetables, also known as nutraceuticals, tend to emerge as chemopreventive agents, with the added benefit of low toxicity and high nutritional values. This paper reviews the present scientific knowledge of the Nrf2/HO-1 signaling as a possible target molecule for chemotherapeutic agents, its basic control mechanisms, and Nrf2/HO-1 inducers produced from natural products that might be employed as cancer chemopreventive drugs. The growing interest in the contribution of the Nrf2/ARE/HO-1 signaling in the development of liver cancer and the Use of nutraceuticals to treat liver cancer by targeting Nrf2/ARE/HO-1.

show abstract

Comparative Analysis of Long Noncoding RNA Expression in Human Hepatocyte Cell Lines and Liver

Cited by 2 publications

References 15 publications

The interplay of long noncoding RNAs and hepatitis B virus

The interplay of long noncoding RNAs and hepatitis B virus

The therapeutic role of nutraceuticals targeting the Nrf2/ HO ‐1 signaling pathway in liver cancer

Contact Info

Product

Resources

About