Comparative analysis of mesenchymal stromal cells from different tissue sources in respect to articular cartilage tissue engineering

Danišovič, Ľuboš; Boháč, Martin; Zamborský, Radoslav; Oravcová, Lenka; Provazníková, Zuzana; Csöbönyeiová, Mária; Varga, Ivan

doi:10.4149/gpb_2015044

Cited by 25 publications

(11 citation statements)

References 27 publications

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“…The results showed that proliferative, differentiation, and metabolism profile of BMSC significantly decreases by age increase [53]. In the other comparative study from 2016, authors did not observe any preference in in vitro chondrogenesis among MSC derived from bone marrow, adipose tissue, and umbilical cord [54].…”

Section: In Vitro Studiesmentioning

confidence: 72%

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Stem Cell-Based Therapies for Osteoarthritis: From Pre-Clinical to Clinical Applications

Toumi¹,

Lespessailles²,

Mazor³

2017

Mesenchymal Stem Cells - Isolation, Characterization and Applications

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Although many surgical and pharmaceutical interventions are currently available for treating osteoarthritis (OA), restoration of normal cartilage function remains inefficient.In fact, because of the absence of vasculature within the articular cartilage (AC), the selfpotential for regeneration is very poor. Recently, researchers and clinicians have been focusing on alternative methods for cartilage preservation and repair. It has been shown that AC contains a population of stem cells or progenitor cells, similar to those found in many other adult tissues that are thought to be involved in the maintenance of tissue homeostasis. In the present chapter, we review the current status of stem cells potential in the treatment of early OA and discuss the possible origin of these cells and the role they might have in cartilage repair. We also review the recent progress in the field of chondroprogenitors in cartilage.

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Section: In Vitro Studiesmentioning

confidence: 72%

“…The recent study from 2016 has emphasized that MSCs from bone marrow, adipose tissue, and umbilical cord share similar biological properties and that their chondrogenic potential does not vary [54].…”

Section: In Vitro Studiesmentioning

confidence: 99%

Stem Cell-Based Therapies for Osteoarthritis: From Pre-Clinical to Clinical Applications

Toumi¹,

Lespessailles²,

Mazor³

2017

Mesenchymal Stem Cells - Isolation, Characterization and Applications

View full text Add to dashboard Cite

show abstract

“…MSCs possess several advantages as follows: 1) MSCs have extensive sources; they could be isolated from various tissues, such as bone marrow, adipose . For example, BMSCs can be obtained from bone marrow by simple gradient centrifugation and washing in phosphate‐buffered saline (PBS); meanwhile, the adipose‐tissue‐derived MSCs (ADMSCs) can be obtained from fresh lipoaspirates by rinsing with sterile PBS, digesting with 0.1% collagenase type I, and gradient centrifugation . 2) MSCs have high proliferative capacity and strong self‐renewal capacity .…”

Section: Therapeutic Cells and Growth Factorsmentioning

confidence: 99%

Progress in Articular Cartilage Tissue Engineering: A Review on Therapeutic Cells and Macromolecular Scaffolds

Zhao

Fan

Chen

et al. 2019

Macromolecular Bioscience

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Repair and regeneration of articular cartilage lesions have always been a major challenge in the medical field due to its peculiar structure (e.g., sparsely distributed chondrocytes, no blood supply, no nerves). Articular cartilage tissue engineering is considered as one promising strategy to achieve reconstruction of cartilage. With this perspective, the articular cartilage tissue engineering has been widely studied. Here, the recent progress of articular cartilage tissue engineering is reviewed. The ad hoc therapeutic cells and growth factors for cartilage regeneration are summarized and discussed. Various types of bio/macromolecular scaffolds together with their pros and cons are also reviewed and elaborated.

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“…A correlation between the chondrogenic potential of MSCs and their tissue source has been suggested. BM-MSCs showed a superior chondrogenic differentiation capacity compared to MSCs from other origins [ 54 – 56 ]. These differences might be explained by variations in gene expression and pathway activation [ 57 ].…”

Section: In Vitro Evidence Of Chondrogenic Diffmentioning

confidence: 99%

Stem Cells for Cartilage Repair: Preclinical Studies and Insights in Translational Animal Models and Outcome Measures

Monaco

Merckx

Ratajczak

et al. 2018

Stem Cells International

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Due to the restricted intrinsic capacity of resident chondrocytes to regenerate the lost cartilage postinjury, stem cell-based therapies have been proposed as a novel therapeutic approach for cartilage repair. Moreover, stem cell-based therapies using mesenchymal stem cells (MSCs) or induced pluripotent stem cells (iPSCs) have been used successfully in preclinical and clinical settings. Despite these promising reports, the exact mechanisms underlying stem cell-mediated cartilage repair remain uncertain. Stem cells can contribute to cartilage repair via chondrogenic differentiation, via immunomodulation, or by the production of paracrine factors and extracellular vesicles. But before novel cell-based therapies for cartilage repair can be introduced into the clinic, rigorous testing in preclinical animal models is required. Preclinical models used in regenerative cartilage studies include murine, lapine, caprine, ovine, porcine, canine, and equine models, each associated with its specific advantages and limitations. This review presents a summary of recent in vitro data and from in vivo preclinical studies justifying the use of MSCs and iPSCs in cartilage tissue engineering. Moreover, the advantages and disadvantages of utilizing small and large animals will be discussed, while also describing suitable outcome measures for evaluating cartilage repair.

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Comparative analysis of mesenchymal stromal cells from different tissue sources in respect to articular cartilage tissue engineering

Cited by 25 publications

References 27 publications

Stem Cell-Based Therapies for Osteoarthritis: From Pre-Clinical to Clinical Applications

Stem Cell-Based Therapies for Osteoarthritis: From Pre-Clinical to Clinical Applications

Progress in Articular Cartilage Tissue Engineering: A Review on Therapeutic Cells and Macromolecular Scaffolds

Stem Cells for Cartilage Repair: Preclinical Studies and Insights in Translational Animal Models and Outcome Measures

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