Comparative Analysis of Sunscreen Nanoencapsulation Processes

Paiva, Thamiris Franckini; Melo, Prı́amo A.; Pinto, José Carlos

doi:10.1002/masy.201600028

Cited by 5 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Figure 1B presents the particle size distributions of the produced nanoparticles, showing a monomodal size distribution with an average diameter of around 170 nm. It is important to highlight that similar nanoparticles were studied previously by others [40], who indicated that these emulsions can be stored stably at rest for at least 6 months at room temperature.…”

Section: Dissolutionmentioning

confidence: 60%

In Vitro Release and In Vivo Pharmacokinetics of Praziquantel Loaded in Different Polymer Particles

et al. 2023

Self Cite

View full text Add to dashboard Cite

Approximately 1 billion people are affected by neglected diseases around the world. Among these diseases, schistosomiasis constitutes one of the most important public health problems, being caused by Schistosoma mansoni and treated through the oral administration of praziquantel (PZQ). Despite being a common disease in children, the medication is delivered in the form of large, bitter-tasting tablets, which makes it difficult for patients to comply with the treatment. In order to mask the taste of the drug, allow more appropriate doses for children, and enhance the absorption by the body, different polymer matrices based on poly(methyl methacrylate) (PMMA) were developed and used to encapsulate PZQ. Polymer matrices included PMMA nano- and microparticles, PMMA-co-DEAEMA (2-(diethylamino)ethyl methacrylate), and PMMA-co-DMAEMA (2-(dimethylamino)ethyl methacrylate) microparticles. The performances of the drug-loaded particles were characterized in vitro through dissolution tests and in vivo through pharmacokinetic analyses in rats for the first time. The in vitro dissolution studies were carried out in accordance with the Brazilian Pharmacopeia and revealed a good PZQ release profile in an acidic medium for the PMMA-DEAEMA copolymer, reaching values close to 100 % in less than 3 h. The in vivo pharmacokinetic analyses were conducted using free PZQ as the control group that was compared with the investigated matrices. The drug was administered orally at doses of 60 mg/kg, and the PMMA-co-DEAEMA copolymer microparticles were found to be the most efficient release system among the investigated ones, reaching a Cmax value of 1007 ± 83 ng/mL, even higher than that observed for free PZQ, which displayed a Cmax value of 432 ± 98 ng/mL.

show abstract

Section: Dissolutionmentioning

confidence: 60%

In Vitro Release and In Vivo Pharmacokinetics of Praziquantel Loaded in Different Polymer Particles

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…Table 1 presents the typical experimental recipe used to prepare the miniemulsions. The formulation shown in Table 1 has been reported by others for production of nanoparticles intended for biomedical applications 29,30. Despite the relatively large amounts of SDS, it can be assured that micellar nucleation does not take place, given the large amount of water and the small characteristic diameter of the produced nanoparticles, as shown in the next sections.…”

Section: Methodsmentioning

confidence: 90%

P(MMA‐co‐AA) Nanoparticles Loaded with Clioquinol and Functionalized with TAT Peptide

Campos

Barros

Ferraz

et al. 2019

Macro Reaction Engineering

Self Cite

View full text Add to dashboard Cite

Polymer nanoparticles produced through miniemulsion polymerizations can be used for design of drug encapsulation and targeted delivery systems. Particularly, the immobilization of functional groups on the surfaces of polymeric nanoparticles enables the development of targeted delivery systems, intended for particle absorption by specific body tissues, favoring the treatment of diseases. For this reason, in the present work poly(methyl methacrylate-co-acrylic acid) (P(MMA-co-AA)) nanoparticles loaded with clioquinol are prepared through in situ miniemulsion polymerizations for the first time. Besides, nanoparticles are functionalized with a cell-penetrating trans-activating transcriptor (TAT) peptide for the first time, to show that incorporation of carboxylic groups (from acrylic acid (AA)) on the particle surfaces provides an effective route for functionalization of nanoparticles with biomolecules. Particularly, it is shown that spherical particles with average sizes between 60 and 100 nm and zeta potential of −50 mV are produced and that the TAT peptide is successfully immobilized onto the particle surfaces. Besides, it is also shown that the clioquinol encapsulation efficiency is equal to 97%. In vitro tests show that 50% of the initial load of clioquinol is released after 9 h of test.

show abstract

“…However, the use of polymer nanoparticles for encapsulation has been highlighted because of their high encapsulation efficiency, high stability in biological fluids, and high stability during storage. [14][15][16] Particularly, the encapsulation of UV filters in polymer nanoparticles presents several competitive advantages, including the restriction of the direct contact of the actives with the skin, the reduction of absorption of such compounds by the skin, and the guarantee of the accumulation of these substances on the stratum corneum, increasing the effectiveness of these compounds. 14,17 Besides, the use of these nanoparticles can also provide some additional advantages that include increasing the stability of organic compounds against UV radiation, reducing the amount of active compound needed to prepare sunscreen formulations, due to the synergistic effect of UV reflection (chemical and physical effects), and restricting possible interactions between the photoactive agents and the various compounds present in the formulation.…”

Section: Introductionmentioning

confidence: 99%

“…The commonest UV filter encapsulation systems include liposomes, nanoemulsions, cyclodextrins, and nanoparticles. However, the use of polymer nanoparticles for encapsulation has been highlighted because of their high encapsulation efficiency, high stability in biological fluids, and high stability during storage 14–16 . Particularly, the encapsulation of UV filters in polymer nanoparticles presents several competitive advantages, including the restriction of the direct contact of the actives with the skin, the reduction of absorption of such compounds by the skin, and the guarantee of the accumulation of these substances on the stratum corneum, increasing the effectiveness of these compounds 14,17 .…”

Section: Introductionmentioning

confidence: 99%

“…Paiva et al 16 carried out a comparative study with different encapsulation systems used to encapsulate AVO and benzophenone‐3: liposomes, nanoemulsions, and PMMA nanoparticles obtained through miniemulsion polymerization. These authors showed that the PMMA nanoparticles exhibited better potential for encapsulation of the investigated actives, leading to higher encapsulation efficiencies, and enhanced stability, when compared to the analyzed liposomes and nanoemulsions.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Encapsulation of organic ultraviolet photoprotective actives into poly(methyl methacrylate) nanoparticles for sunscreen formulations

Miranda,

Dutra,

Pinto

et al. 2024

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

Skin cancer is the most common of all cancers worldwide. This way, it is mandatory to adopt an adequate sun protection routine, including sunscreen lotions. However, despite the proven effectiveness of numerous chemical filters, many of them are also known for their allergenic and carcinogenic potential effects, which can be mitigated by exploring some encapsulation routes. Thus, the present work evaluates the influence of seven distinct ultraviolet (UV) organic filters on the final particle size and molecular weight distributions of poly(methyl methacrylate) (PMMA) beads. Moreover, the sun protection factors (SPF) of the loaded nanoparticles are also evaluated when used for preparation of sunscreen formulations. The UV filters did not affect the course of MMA miniemulsion polymerizations significantly, enabling the synthesis of loaded nanoparticles. Nevertheless, adding the filters shifted the particle size distributions toward larger diameters, which are appropriate for cosmetic formulations. Based on the SPF analyses, it was also possible to observe a 12‐fold increase in the SPF values of the prepared formulations and an increase in the critical wavelength. Therefore, the in situ incorporation of distinct UV filters during miniemulsion MMA polymerizations constitutes a robust and versatile technology to produce PMMA nanoparticles loaded with UV filters for preparation of sunscreen formulations.

show abstract

Comparative Analysis of Sunscreen Nanoencapsulation Processes

Cited by 5 publications

References 24 publications

In Vitro Release and In Vivo Pharmacokinetics of Praziquantel Loaded in Different Polymer Particles

In Vitro Release and In Vivo Pharmacokinetics of Praziquantel Loaded in Different Polymer Particles

P(MMA‐co‐AA) Nanoparticles Loaded with Clioquinol and Functionalized with TAT Peptide

Encapsulation of organic ultraviolet photoprotective actives into poly(methyl methacrylate) nanoparticles for sunscreen formulations

Contact Info

Product

Resources

About