Comparative analysis of the antioxidant and DNA protection capacities of Anadenanthera colubrina, Libidibia ferrea and Pityrocarpa moniliformis fruits

Silva, Luís Cláudio Nascimento da; Silva, Carlos Alberto da; Souza, Renata M. C. R. de; Macêdo, Alexandre José; Silva, Márcia Vanusa da; Correia, Maria Tereza dos Santos

doi:10.1016/j.fct.2011.06.019

Cited by 42 publications

(34 citation statements)

References 43 publications

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“…In the same way, Basma et al (2011) assessing antioxidant activities of Euphorbia hirta extracts found a relevant correlation between phenol content and IC 50 DPPH values (R 2 = 0.989) but on the other hand, a moderate correlation was found between flavonoid content and IC 50 DPPH (R 2 = 0.696). Silva et al (2011) working with hydroalcoholic extracts of Anadenanthera colubrina, Libidibia ferrea and Pityrocarpa moniliformis fruits noted correlation between polyphenols and TAC (p = 0.923, R 2 = 0.862). In fact it is well known that there is a strong relationship between phenolic content and antioxidant activity in plants (Abdelhady et al, 2011;Hossain and Shah, 2015).…”

Section: Resultsmentioning

confidence: 99%

Phytochemical screening, total phenolic content and antioxidant activity of some plants from Brazilian flora

Neto¹,

Uchôa²,

Moura³

et al. 2016

J. Med. Plants Res.

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The present study evaluated the total phenolic and flavonoid content as well as the antioxidant activity of methanolic leaf extracts of five plants from Brazilian flora: Abarema cochliacarpos, Croton corchoropsis, Myroxylon peruiferum, Stryphnodendron pulcherrimum and Tanaecium cyrtanthum by 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH) and total antioxidant capacity assays. A thin layer chromatography analysis of all plant extracts has also been performed and it showed the presence of different types of secondary metabolites, namely saponins, phenylpropanoids and flavonoids. Among the studied plants, A. cochliacarpos and S. pulcherrimum showed considerable antioxidant radical scavenging activity on all the tested assays and they also exhibited substantial amounts of phenolic compounds. In addition, a positive correlation was found between total phenols and both ABTS radical scavenging activity and total antioxidant capacity assays, thus indicating the major role of phenols on the antioxidant activity of these plants. To the best of the authors' knowledge, this is the first approach where the phenolic content and antioxidant activity of A. cochliacarpos, C. corchoropsis, M. peruiferum, S. pulcherrimum and T. xanthophyllum were explored.

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Section: Resultsmentioning

confidence: 99%

Phytochemical screening, total phenolic content and antioxidant activity of some plants from Brazilian flora

Neto¹,

Uchôa²,

Moura³

et al. 2016

J. Med. Plants Res.

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“…Previous studies have shown biological activities of the extracts of fruit and stem L. ferrea, such as antiinflammatory (Carvalho et al 1996;Pereira et al 2012), and antimicrobial, whereas fruit extract can inhibit in vitro growth of oral pathogens (Sampaio et al 2009), and antioxidant (Silva et al 2011), but this was the first screening with different extracts obtained from L. ferrea evaluated for Leishmania species. However, previous studies showed that the topical use of L. ferrea ointment was significantly efficient to help healing cutaneous wounds in goats (Oliveira et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Antileishmanial activity of extracts from Libidibia ferrea: development of in vitro and in vivo tests

et al. 2017

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Treatment of cutaneous leishmaniasis (CL) is difficult due to the scarce number of drugs able to eliminate completely the intracellular form of the parasite. In the present study, the aim was to evaluate: i) phytochemical properties of extracts from Libidibia ferrea; ii) antileishmanial activity of extracts from L. ferrea against promastigotes and amastigotes of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) guyanensis; iii) the effects of topical treatment using hydrogel containing active extract of L. ferrea on golden hamsters infected with L. (L.) amazonensis. Extracts from leaves, branches and fruits of L. ferrea were obtained with hexane and methanol and were tested by in vitro assays in promastigotes and murine macrophages J774 experimentally infected with amastigotes of Leishmania. Groups of hamsters with CL received topical treatment with a formulation of extract (10%) hydrogels, 50 mg.day ) e baixa citotoxicidade em células de macrófagos J774. Os resultados destacaram que as lesões cutâneas de animais que receberam tratamento com hidrogel + extrato (GelFrMeOH) apresentaram redução significativa (42,78%), menos úlceração e redução da carga parasitária detectada por RT-qPCR, microscopia e análise em cultura e alterações histopatológicas, como menor infiltrado inflamatório após 40 dias de tratamento. A análise química demonstrou que FrMeOH contém altos níveis de compostos fenólicos. Os resultados apontam para uma possível terapia alternativa para CL utilizando fitoterápicos. PALAVRAS-CHAVE: leishmaniose cutânea, formulações tópicas, produtos naturais, tratamento experimental

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“…[4][5][6][7]12,17 In our previous studies the antimicrobial action of extracts and fractions from leaves and fruits of A. colubrina was reported against Gram-positive bacteria, and no activity was observed against Gram negative bacteria. [4][5][6]12 In the present work we employed a different extraction method, by which we obtained extracts with activity against tested Gram negative bacteria. Anyway, the best activity was found against S. aureus and B. subtilis, and ethyl acetate extracts had the best activity.…”

Section: Discussionmentioning

confidence: 99%

“…2,3 Previous studies demonstrated the antimicrobial potential of leaves and fruits of this plant, especially against Staphylococcus aureus. [4][5][6]12 In this context, the present study aims to analyze the effects of rainfall on the antimicrobial activity and secondary metabolites contents of leaves and fruits of Anadenanthera colubrina. With this information, the best collection time to maximize the bioactive compounds extraction for medicinal purposes may be determined.…”

Section: Introductionmentioning

confidence: 99%

“…2,3 For some of those, scientific evidences confirm these therapeutic aptitudes. [4][5][6][7] In recent years, the ethnomedicinal knowledge has stimulated several studies about the pharmaceutical potential of natural products of northeastern Brazil. 8 This is justified by the fact that the intrinsic features of Caatinga area (drought, high solar radiation rates and other environmental stresses) influence the synthesis of secondary metabolites of its plants, 9 making them attractive targets for bioprospecting programs.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Rainfall on the Antimicrobial Activity and Secondary Metabolites Contents of Leaves and Fruits of Anadenanthera colubrina from Caatinga Area

Araújo¹,

Silva²,

Harand³

et al. 2017

Phcog J

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Background: Anadenanthera colubrina (Vell.) Brenan var. cebil (Griseb) is a plant widely used for medicinal proposes in Brazilian Northeast. Objective: This study aimed to analyze the influence of rainfall indexes (RI) in antimicrobial activity and phytochemical constituents of extracts from leaves and fruits of A. colubrina. Material and Methods: Samples were collected in Catimbau National Park (Buíque, Pernambuco, Brazil) at September 2010 (RI: 75 mm) and January (RI: 65 mm), April (RI: 162 mm) and June 2011 (RI: 73 mm). The extracts were prepared by Soxhlet extraction using cyclohexane, chloroform, ethyl acetate and methanol. The antimicrobial activity was determined by MIC and MBC values. Results: All extracts showed antimicrobial activity, but ethyl acetate extracts (from all periods) were more active. Strong correlations were found between the RI and the average MIC of MLE (ρ: -0.99), EALE (ρ: -0.81), CHFE (ρ: -0.81), EAFE (ρ: -0.80); while moderate and weak correlations were found for other extracts. Through a HPLC analysis was possible to reveal that the samples collected from dry periods had more chemical diversity (as they presented more peaks). Gallic acid and quercetin (and derivative compounds) were identified. The levels of quercetin were enhanced in extracts from dry months. Conclusion: Our results showed that the rainfall has a positive effect on the antimicrobial activity of leaves and fruits of A. colubrina, however these extracts showed more chemical diversity during dry months.

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Comparative analysis of the antioxidant and DNA protection capacities of Anadenanthera colubrina, Libidibia ferrea and Pityrocarpa moniliformis fruits

Cited by 42 publications

References 43 publications

Phytochemical screening, total phenolic content and antioxidant activity of some plants from Brazilian flora

Phytochemical screening, total phenolic content and antioxidant activity of some plants from Brazilian flora

Antileishmanial activity of extracts from Libidibia ferrea: development of in vitro and in vivo tests

Effects of Rainfall on the Antimicrobial Activity and Secondary Metabolites Contents of Leaves and Fruits of Anadenanthera colubrina from Caatinga Area

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