Comparative Analysis of the Differences in Metabolic Disorder and Atherosclerotic Cardiovascular Disease (Ascvd) Risk Between Han and Kazakh Populations in Xinjiang

Abstract

Background: Our study aimed to analyse the characteristics of glucose and lipid metabolism in a healthy Han and Kazakh population in Barkol Kazakh Autonomous County. Methods: We enrolled 4,400 subjects in Barkol Kazakh Autonomous County. The patients’ basic characteristics were recorded, chemical parameters were tested, and the characteristics of glucose and lipid metabolism between the Han and Kazakh ethnic groups were evaluated.Results: We found significant differences in glucose and lipid metabolism between Han and Kazakh people; individuals of the Han ethnicity had higher FPG and TGs but lower BMI, blood pressure, TC and LDL-C than those of the Kazakh ethnicity. Similar results remained after the participants were divided by sex. Regarding the detection rate of metabolic disorders, we observed higher rates of glucose and TG disorders but lower rates of TC, HDL-C and LDL-C disorders in individuals of the Han ethnicity than in those of the Kazakh ethnicity. For atherosclerotic cardiovascular disease (ASCVD) risk, the detection rate of an LDL-C level ≥ 4.1 mmol/L was significantly higher in Kazakh individuals than in Han individuals. However, regarding hyperglycaemic patients aged 40 years orolder with 1.8 ≤ LDL-C ≤ 4.9 mmol/L, the detection rate was higher in the Han individuals than in the Kazakh individuals. Similar results were also observed after we divided these participants by sex.Conclusion: Our study evaluated metabolic disorders in the Han and Kazakh people in Balikun County and found that metabolic disorders showed sex, ethnic and metabolite component heterogeneity.