Comparative Analysis of the Efficiency of Chicken and Rabbit Antibodies in Competitive Enzyme Linked Immunoassay for the Detection of Bovine Beta-Casomorphin 7

Pechelyulko, A. A.; Tarakanova, Yu. N.; Dmitriev, D. A.; Massino, Yu. S.; Kost, V. Y.; Рогожин, Е. А.; Segal, O.L.; Дмитриев, А. Д.

doi:10.1134/s0003683819060103

Cited by 1 publication

(1 citation statement)

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“…In addition, hens are better antibody producers than rabbits, because they produce higher levels of antibodies with fewer immunizations [ 47 , 48 ]. In competition assays, it has been shown that IgY recognizes their antigens with an affinity five times higher than the corresponding mammalian IgG [ 49 ].…”

Section: The Production Capacity Of Igy Antibodiesmentioning

confidence: 99%

Can Immunization of Hens Provide Oral-Based Therapeutics against COVID-19?

et al. 2020

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In the current worldwide pandemic situation caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the newest coronavirus disease (COVID-19), therapeutics and prophylactics are urgently needed for a large population. Some of the prophylaxis strategies are based on the development of antibodies targeting viral proteins. IgY antibodies are a type of immunoglobulin present in birds, amphibians, and reptiles. They are usually obtained from egg yolk of hyper-immunized hens and represent a relatively inexpensive source of antibodies. Specific IgY can be produced by immunizing chickens with the target antigen and then purifying from the egg yolk. Chicken IgY has been widely explored as a clinical anti-infective material for prophylaxis, preventive medicine, and therapy of infectious diseases. Administered non-systemically, IgY antibodies are safe and effective drugs. Moreover, passive immunization with avian antibodies could become an effective alternative therapy, as these can be obtained relatively simply, cost-efficiently, and produced on a large scale. Here, we highlight the potential use of polyclonal avian IgY antibodies as an oral prophylactic treatment for respiratory viral diseases, such as COVID-19, for which no vaccine is yet available.

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Section: The Production Capacity Of Igy Antibodiesmentioning

confidence: 99%