Comparative analysis of the expression of proliferating cell nuclear antigen, p53, bax, and bcl-2 in oral lichen planus and oral squamous cell carcinoma

Sousa, Fernando Augusto Cervantes Garcia de; Paradella, Thaís Cachuté; Carvalho, Yasmin Rodarte; Rosa, Leonardo Cruz da

doi:10.1016/j.anndiagpath.2009.06.001

Cited by 28 publications

(48 citation statements)

References 37 publications

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“…Similarly, de Sousa et al (2009a) reported a lower proliferation rate, determined by PCNA marker, in OLP compared to OSCC with significant difference between the two groups.…”

Section: Discussionmentioning

confidence: 81%

“…During last decades many studies considered risk of OSCC development for OLP as it was classified as a premalignant condition (de Sousa et al, 2009a;JaafariAshkavandi et al, 2011;Shen et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…It is revealed that Ki67expression in premalignant and malignant oral lesions increases according to their degree of malignancy (Montebugnoli et al, 2009;Ranganathan and Kavitha, 2011;Dragomir et al, 2012) and increased cellular proliferation might have a potential to be an initial indicator to malignant transformation potential of a lesion (de Sousa et al, 2009a;. Objective of this study is to evaluate and compare cell proliferation rate in OLP , epithelial dysplasia and OSCC through immunohistochemical expression of Ki67.…”

Section: Introductionmentioning

confidence: 94%

“…This chronic inflammatory oral mucosal disease has also been considered as a potential precancerous disorder (de Sousa et al, 2009a ;García-García et al, 2012 matter of controversy (de Sousa et al, 2009a;JaafariAshkavandi et al, 2011;Shen et al, 2011). According to Safadi et al (2010) some previous studies rate of developing cancer in OLP has been reported from 0.5-12.5% (Safadi et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…One of the mechanisms essential for cancer to develop is enhancement of proliferation capacity (de Sousa et al, 2009a;. Cell proliferation rate can be evaluated through immunohistochemical study of proliferation related antigens (Watanabe et al, 2010;Bologna-Molina et al, 3013).…”

Section: Introductionmentioning

confidence: 99%

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Suitability/Unsuitability of Cell Proliferation as an Indicator of Malignant Potential in Oral Lichen Planus: an Immunohistochemical Study

Zargaran

Jamshidi²,

Eshghyar³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Oral lichen planus (OLP) is categorized as premalignant lesion although its malignant potential is a matter of controversy. The objective of this study was to investigate Ki67 expression in OLP, oral epithelial dysplasia and oral squamous cell carcinoma (OSCC). Materials and Methods: Expression of Ki67 was evaluated through immunohistochemistry (IHC) in groups of A (17 cases of epithelial hyperplasia), B (16 cases of OLP), C1 (10 cases of mild epithelial dysplasia), C2 (10 cases of severe epithelial dysplasia), D1 (10 cases of well-differentiated OSCC), and D2 (10 cases of poorly-differentiated OSCC). Results: There was a significant difference in Ki67 expression based on quantitative analysis among the six studied groups as well as group B compared bilaterally with groups C2, D1 and D2 (p< 0.0001). However, there was no significant difference between groups B and C1 or between groups D1 and D2 (p> 0.05). Conclusions: Based on the results of the present study it may not be possible to definitely consider malignant transformation potential for OLP. However, expression of Ki67 was significantly higher in OLP than that of epithelial hyperplasia with no significant difference from that of mild epithelial dysplasia. This should be considered by clinicians to carefully and regularly follow up OLP lesions to detect potential subtle changes at an early stage.

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“…Similarly, de Sousa et al (2009a) reported a lower proliferation rate, determined by PCNA marker, in OLP compared to OSCC with significant difference between the two groups.…”

Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Suitability/Unsuitability of Cell Proliferation as an Indicator of Malignant Potential in Oral Lichen Planus: an Immunohistochemical Study

Zargaran

Jamshidi²,

Eshghyar³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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[6]‐Shogaol, a Novel Chemopreventor in 7,12‐Dimethylbenz[a]anthracene‐induced Hamster Buccal Pouch Carcinogenesis

Suresh

Annamalai

2016

Phytotherapy Research

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Oral cancer is a major cause of morbidity and mortality in developing countries. Despite advances in chemotherapy for the cancer management, the survival rate has not yet been improved. Dietary nutrient has been receiving a lot of attention and interest in the chemotherapeutic development. [6]-Shogaol is a major bioactive compound identified in ginger that possesses many pharmacological properties. The aim of the present study is to investigate the effect of [6]-shogaol on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch (HBP) carcinogenesis. Oral squamous cell carcinoma induced in HBP by painting with 0.5% 7,12-dimethylbenz(a)anthracene (DMBA), thrice in a week for 16 weeks. We observed 100% tumour incidence, decreased levels of lipid peroxidation, antioxidant, and phase II detoxification enzymes (GST, GR and GSH) in DMBA-induced hamsters. Further, enhanced activity of phase I enzymes (cytochrome p450 and b5) and over-expression of mutant p53, Bcl-2 and decreased expression of wild type p53 and Bax were noticed in DMBA-induced hamsters. Our results indicated that [6]-shogaol (10, 20 and 40 mg/kg body weight) treated with DMBA-painted hamsters, considerably reversed tumour incidence, improved antioxidant status, phase II detoxification enzymes, and also inhibit lipid peroxidation and phase I enzymes. Moreover, [6]-shogaol inhibits mutant p53 and Bcl-2 expression and significantly restored normal p53, Bax levels. Thus, we concluded that [6]-shogaol prevents DMBA-induced HBP carcinogenesis through its antioxidant as well as modulating apoptotic signals.

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Lichen Planus

Bragazzi¹,

Nicolini²

2015

Genomics, Personalized Medicine and Oral Disease

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Comparative analysis of the expression of proliferating cell nuclear antigen, p53, bax, and bcl-2 in oral lichen planus and oral squamous cell carcinoma

Cited by 28 publications

References 37 publications

Suitability/Unsuitability of Cell Proliferation as an Indicator of Malignant Potential in Oral Lichen Planus: an Immunohistochemical Study

Suitability/Unsuitability of Cell Proliferation as an Indicator of Malignant Potential in Oral Lichen Planus: an Immunohistochemical Study

[6]‐Shogaol, a Novel Chemopreventor in 7,12‐Dimethylbenz[a]anthracene‐induced Hamster Buccal Pouch Carcinogenesis

Lichen Planus

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