Comparative analysis of the human gimap gene cluster encoding a novel GTPase family

Krücken, Jürgen; Schroetel, Regina M.U.; Müller, Ilse; Saïdani, Nadia; Marinovski, Predrag; Benten, W. Peter M.; Stamm, Olaf; Wunderlich, Frank

doi:10.1016/j.gene.2004.07.005

Cited by 108 publications

(171 citation statements)

References 30 publications

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“…Diverse cancer tissue and cell lines, including leukemias and lymphomas, expressed the gene at albeit very low levels (Krucken et al, 2004). In our case, we did not detect FL-aa-7 mRNA in any of the tumor samples.…”

Section: Discussioncontrasting

confidence: 56%

Cloning of B cell lymphoma-associated antigens using modified phage-displayed expression cDNA library and immunized patient sera

Chul

Kwak²,

Ruffini

et al. 2006

Journal of Immunological Methods

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Active immunization of follicular lymphoma patients with idiotypic vaccines elicits antigen-specific antibody responses, T-cell responses, and antitumor effects. We hypothesized that these vaccinated patients could generate tumor-specific immune responses, not only against idiotype, but also against other tumor-associated antigens (TAA) by a mechanism of epitope spreading. To identify potential antigens, a phage surface expressed cDNA library derived from primary tumor cells was screened with sera from idiotypevaccinated patients. Consistent with our hypothesis, we identified two immunogenic peptides (FL-aa-7 and 18), unrelated to idiotype, which were recognized by postvaccine sera but not by prevaccine or normal human sera. These peptide sequences derived from the 5′-untranslated regions of the human GTPase, IMAP family member 7 gene (FL-aa-7) and an alternative reading frame of U1-snRNP 70 (FL-aa-18), respectively, suggesting that epitope spreading had occurred.

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Section: Discussioncontrasting

confidence: 56%

Cloning of B cell lymphoma-associated antigens using modified phage-displayed expression cDNA library and immunized patient sera

Chul

Kwak²,

Ruffini

et al. 2006

Journal of Immunological Methods

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“…Ifi44 has also been markedly induced in the liver in response to hepatitis C in chimpanzees (Kitamura et al 1994), although no modulation of this gene had previously been reported in NAFLD. Additionally, two of the most regulated genes, gimap7 and gimap8l, are GTPases of the immunity-associated protein family, which is an evolutionarily conserved group that appears to be immunity modulated (Krücken et al 2004). However, more studies are needed to decipher the different functions of its members.…”

Section: Model Characterizationmentioning

confidence: 99%

Liver immune responses to inflammatory stimuli in a diet-induced obesity model of zebrafish

Forn-Cuní¹,

Varela²,

Fernández-Rodrı́guez³

et al. 2014

Journal of Endocrinology

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Obesity-and metabolic syndrome-related diseases are becoming important medical challenges for the western world. Non-alcoholic fatty liver disease (NAFLD) is a manifestation of these altered conditions in the liver, and inflammation appears to be a factor that is tightly connected to its evolution. In this study, we used a diet-induced obesity approach in zebrafish (Danio rerio) based on overfeeding to analyze liver transcriptomic modulation in the disease and to determine how obesity affects the immune response against an acute inflammatory stimulus such as lipopolysaccharide (LPS). Overfed zebrafish developed an obese phenotype, showed signs of liver steatosis, and its modulation profile resembled that observed in humans, with overexpression of tac4, col4a3, col4a5, lysyl oxidases, and genes involved in retinoid metabolism. In response to LPS, healthy fish exhibited a typical host defense reaction comparable to that which occurs in mammals, whereas there was no significant gene modulation when comparing expression in the liver of LPS-stimulated and non-stimulated obese zebrafish at the same statistical level. The stimulation of obese fish represents a double-hit to the already damaged liver and can help understand the evolution of the disease. Finally, a comparison of the differential gene activation between stimulated healthy and obese zebrafish revealed the expected difference in the metabolic state between healthy and diseased liver. The differentially modulated genes are currently being studied as putative new pathological markers in NAFLD-stimulated liver in humans.

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“…Interestingly, we also noted preferential expression of GIMAP6 (hIAN2) by T cells (supplementary Table I). This family is relatively poorly characterized to date; however, members of this family seem to be highly expressed in the spleen and lymph nodes, and there is increasing evidence of their importance in T cell development and maturation (25)(26)(27). Fig.…”

Section: Comprehensive Leukocyte Subset Profiling Allows the Identitymentioning

confidence: 99%

Identification of T Cell-Restricted Genes, and Signatures for Different T Cell Responses, Using a Comprehensive Collection of Microarray Datasets

Chtanova

Newton

Liu

et al. 2005

The Journal of Immunology

117

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Comparative analysis of the human gimap gene cluster encoding a novel GTPase family

Cited by 108 publications

References 30 publications

Cloning of B cell lymphoma-associated antigens using modified phage-displayed expression cDNA library and immunized patient sera

Cloning of B cell lymphoma-associated antigens using modified phage-displayed expression cDNA library and immunized patient sera

Liver immune responses to inflammatory stimuli in a diet-induced obesity model of zebrafish

Identification of T Cell-Restricted Genes, and Signatures for Different T Cell Responses, Using a Comprehensive Collection of Microarray Datasets

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