Comparative analysis of the new guidelines and consensuses for the management of hypothyroidism, thyroid nodules, and differentiated thyroid cancer

Paz-Filho, Gilberto; Graf, Hans; Ward, Laura Sterian

doi:10.1590/s0004-27302013000400001

Cited by 4 publications

(2 citation statements)

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“…Administration of Panax ginseng resulted in noticeable increase in the THs and this could attributed to the thyromimetric effect of ginseng. (16). Ginseng is aromatic herb containing high level of iodine which is main component of the thyroid hormones.…”

Section: Discussionmentioning

confidence: 99%

Can Panax Ginseng protect against fertility disorders in hypothyroid female albino rats?

Elgoly

Wahman

Yousef

2018

Cell Mol Biol (Noisy-le-grand)

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Hypothyroidism is an endocrine disorder due to decreased thyroid hormone production. This endocrine disorder significantly affects the menstrual cycle and fertility. The aim of this present study was to assess the efficacy of Panax ginseng, one of traditional Chinese medicine, in ameliorating the gonadal hormonal dysfunction and lowering oxidative stress accompanied with hypothyroidism in adult female albino rats. After confirming regularity of the oestrus cycle in the female rats in this study, hypothyroidism was induced by using daily 5.0 mg kg-1 oral dose of Neo-mercazole. The hypothyroid rats were randomly grouped into two groups; hypothyroid group (H): did not received any treatment, group II (H+G) was treated with Panax ginseng extract for one months after hypothyroidism induction. Another two groups were included in the study, a negative control group (Euthyroid group) and a positive control group; received Panax ginseng extract only. Hypothyroidism resulted in irregularity of oestrus cycle accompanied with decrease in luteinizing hormone (LH), follicular stimulating hormone (FSH) and estradiol (E 2 ), while prolactin (PRL), progesterone (P) and testosterone (T) hormone were significantly elevated. Hypothyroidism elevated capsae-3 and 8OH-deoxy guanosine expression and increased secretion of corticosterone and ERK1/2. This study showed that Panax ginseng improved hypothyroid-induced deterioration in trophic and gonadal hormones through free radicals' scavenger.

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Section: Discussionmentioning

confidence: 99%

Can Panax Ginseng protect against fertility disorders in hypothyroid female albino rats?

Elgoly

Wahman

Yousef

2018

Cell Mol Biol (Noisy-le-grand)

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“…L evothyroxine sodium (LT4) is the drug of choice for the treatment of patients with hypothyroidism (1)(2)(3)(4)(5). The LT4 formulations available have a half-life of six days and provide fairly stable blood levels of thyroxine (T4) after ingestion of an oral daily dose (6).…”

Section: Introductionmentioning

confidence: 99%

Treatment of hypothyroidism with levothyroxine plus liothyronine: a randomized, double-blind, crossover study

Kaminski

Miasaki

Paz-Filho

et al. 2016

Arch. Endocrinol. Metab.

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Objective: To compare the effects of a unique fixed combination levothyroxine/liothyronine (LT4/LT3) therapy in patients with primary hypothyroidism. Subjects and methods: This is a randomized, double-blind, crossover study. Adults with primary hypothyroidism (n = 32, age 42.6 ± 13.3, 30 females) on stable doses of LT4 for ≥ 6 months (125 or 150 μg/day) were randomized to continue LT4 treatment (G1) or to start LT4/LT3 therapy (75/15 μg/day; G2). After 8 weeks, participants switched treatments for 8 more weeks. Thyroid function, lipid profile, plasma glucose, body weight, electrocardiogram, vital signs, and quality of life (QoL) were evaluated at weeks 0, 8 and 16. Results: Free T4 levels were significantly lower while on LT4/LT3 (G1: 1.07 ± 0.29 vs. 1.65 ± 0.46; G2: 0.97 ± 0.26 vs. 1.63 ± 0.43 ng/dL; P < 0.001). TSH and T3 levels were not affected by type of therapy. More patients on LT4/ LT3 had T3 levels above the upper limit (15% vs. 3%). The combination therapy led to an increase in heart rate, with no significant changes in electrocardiogram or arterial blood pressure. Lipid profile, body weight and QoL remained unchanged. Conclusions: The combination therapy yielded significantly lower free T4 levels, with no changes in TSH or T3 levels. More patients on LT4/T3 had elevated T3 levels, with no significant alterations in the evaluated outcomes. No clear clinical benefit of the studied formulation could be observed. Future trials need to evaluate different formulations and the impact of the combined therapy in select populations with genetic polymorphisms. Arch Endocrinol Metab. 2016;60(6):562-72

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Nontoxic Multinodular Goiter

Paz-Filho

Graf

2019

The Thyroid and Its Diseases

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Comparative analysis of the new guidelines and consensuses for the management of hypothyroidism, thyroid nodules, and differentiated thyroid cancer

Cited by 4 publications

References 14 publications

Can Panax Ginseng protect against fertility disorders in hypothyroid female albino rats?

Can Panax Ginseng protect against fertility disorders in hypothyroid female albino rats?

Treatment of hypothyroidism with levothyroxine plus liothyronine: a randomized, double-blind, crossover study

Nontoxic Multinodular Goiter

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