Comparative analysis of the physicochemical and anti-biofilm properties of iota and lambda carrageenan-capped silver nanocomposites synthesized using response surface methodology

Singh, Khushboo; Pathak, Anupam; Poluri, Krishna Mohan

doi:10.1039/d3nj02293e

Cited by 5 publications

(1 citation statement)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, RSM aided in characterizing nanocomposites and optimizing stability. Antibiofilm studies showcased the potency of these nanocomposites, especially in eradicating Pseudomonas aeruginosa biofilms, highlighting RSM’s role in enhancing their antibiofilm properties [ 23 ]. Gharbani et al (2023) demonstrated RSM’s ability to assess the synergistic antibacterial effect of natural compounds, offering an eco-friendly alternative to chemical preservatives.…”

Section: Introductionmentioning

confidence: 99%

Response Surface Methodology Application for Bacteriophage–Antibiotic Antibiofilm Activity Optimization

Grygorcewicz,

Gliźniewicz,

Olszewska

et al. 2023

Microorganisms

View full text Add to dashboard Cite

Phage–antibiotic combination-based protocols are presently under heightened investigation. This paradigm extends to engagements with bacterial biofilms, necessitating novel computational approaches to comprehensively characterize and optimize the outcomes achievable via these combinations. This study aimed to explore the Response Surface Methodology (RSM) in optimizing the antibiofilm activity of bacteriophage–antibiotic combinations. We employ a combination of antibiotics (gentamicin, meropenem, amikacin, ceftazidime, fosfomycin, imipenem, and colistin) alongside the bacteriophage vB_AbaP_AGC01 to combat Acinetobacter baumannii biofilm. Based on the conducted biofilm challenge assays analyzed using the RSM, the optimal points of antibiofilm activity efficacy were effectively selected by applying this methodology, enabling the quantifiable mathematical representations. Subsequent optimization showed the synergistic potential of the anti-biofilm that arises when antibiotics are judiciously combined with the AGC01 bacteriophage, reducing biofilm biomass by up to 80% depending on the antibiotic used. The data suggest that the phage–imipenem combination demonstrates the highest efficacy, with an 88.74% reduction. Notably, the lower concentrations characterized by a high maximum reduction in biofilm biomass were observed in the phage–amikacin combination at cA = 0.00195 and cP = 0.38 as the option that required minimum resources. It is worth noting that only gentamicin antagonism between the phage and the antibiotic was detected.

show abstract

Section: Introductionmentioning

confidence: 99%

Response Surface Methodology Application for Bacteriophage–Antibiotic Antibiofilm Activity Optimization

Grygorcewicz,

Gliźniewicz,

Olszewska

et al. 2023

Microorganisms

View full text Add to dashboard Cite

show abstract

Green Synthesis of Silver Nanoparticles from Energy Cane Bagasse Hydrolysate: Antimicrobial and Antibiofilm Properties

Aita,

Moon

2024

Sugar Tech

View full text Add to dashboard Cite

Functionalized nanocatalytic PVDF membrane reactor for degradation of hazardous azo dyes

Singh,

Gulati,

Poluri

2025

Chemical Engineering Journal

View full text Add to dashboard Cite

Comparative analysis of the physicochemical and anti-biofilm properties of iota and lambda carrageenan-capped silver nanocomposites synthesized using response surface methodology

Abstract: Antimicrobial resistance of microbes due to the formation of biofilms is a global industrial, environmental, and health concern. The current study presents the synthesis, characterization, and functional assessment of two...

Cited by 5 publications

References 83 publications

Response Surface Methodology Application for Bacteriophage–Antibiotic Antibiofilm Activity Optimization

Response Surface Methodology Application for Bacteriophage–Antibiotic Antibiofilm Activity Optimization

Green Synthesis of Silver Nanoparticles from Energy Cane Bagasse Hydrolysate: Antimicrobial and Antibiofilm Properties

Functionalized nanocatalytic PVDF membrane reactor for degradation of hazardous azo dyes

Contact Info

Product

Resources

About