Comparative antioxidant and antimicrobial potentials of leaf successive extract fractions of poison bulb, Crinum asiaticum L.

Goswami, Sumanta; Das, Rabindra Nath; Ghosh, Prasanta Kumar; Chakraborty, Tista; Barman, Anuva; Ray, Swati

doi:10.1016/j.indcrop.2020.112667

Cited by 25 publications

(16 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Phenolic compounds contribute to antioxidant activity [ 32 , 33 ]. Oxidative stress activates inflammatory mediators linked to the overproduction of ROS involved in several chronic inflammatory diseases [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Various Preextraction Treatments of Crinum asiaticum Leaf on Its Anti-Inflammatory Activity and Chemical Properties

Kongkwamcharoen

Itharat

Pipatrattanaseree³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Crinum asiaticum Linn. has been used in Thai traditional medicine to relieve inflammatory symptoms and treat osteoarthritis. There have been reports on its potent anti-inflammatory property but nothing on the effects of different pretreatments on its chemical properties and anti-inflammatory activity. Pretreatment of herbal raw materials is an important step which affects the overall quality of Thai traditional medicine. The objectives of this study were to investigate different treatments of C. asiaticum leaves prior to ethanolic extraction and to compare the extracts for their anti-inflammatory activity and chemical properties. The treatments included hot air drying in an oven, microwave drying, traditional grilling on a charcoal stove before drying in an oven, and temperature shock in hot and cold water before hot air drying. The anti-inflammatory activity and chemical properties of the extracts were analyzed using the established methods. Results showed that 95% ethanolic extract of hot air oven-dried leaves had the highest anti-inflammatory activity and total phenolic and lycorine contents. We recommend hot air drying as a preextraction treatment for C. asiaticum leaves for its simplicity, best retention of the herbal quality, and suitability for scaling up to an industrial process.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Various Preextraction Treatments of Crinum asiaticum Leaf on Its Anti-Inflammatory Activity and Chemical Properties

Kongkwamcharoen

Itharat

Pipatrattanaseree³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Though the EC 50 values of ascorbic acid for both DPPH and FRAP assays were lower than the most effective fraction, AQF, but despite being a mixture of compounds, its required concentration was only thrice to the standard. It is reported that most of the antioxidant compounds responsible for plants bioactivity are mainly phenolics and/or flavonoids which are extracted in polar solvents as the crude extract contains a rich combination of phytochemicals, while a specific fraction of any successive extraction procedure have fewer types of molecules due to their solvent affinity and polarity 6,8,9,10,28 . The differential total antioxidant activity (TAC) of the different organic solvent-mediated extracts of various medicinal plants were reported due to their variations in phenolics content 8,9,28 .…”

Section: Discussionmentioning

confidence: 99%

“…An earlier study indicated that the crude leaf methanolic extract of C. citrinus and its extract fractions have differential free radical scavenging potentials and that also supports our findings that water is more suitable than petroleum ether for extracting bioactive antioxidant molecules from C. citrinus leaf 23 . Recently, through a comparative study, our laboratory reported that the successive leaf aqueous extract fraction of Crinum asiaticum having the highest antioxidant and antibacterial potentials along with the highest phenolics contents 8 .…”

Section: Discussionmentioning

confidence: 99%

“…Antioxidant quenches free radicals through several ways, like hydrogen-atom transfer (HAT) or single-electron transfer (SET) or both, and also repressing ROS/RNS generation by silencing some enzymes or chelating trace metals involved in reactive species production 1,2 . Several scientific reports indicated antioxidant properties of the different plant parts (leaves, fruits, barks or bulbs) and a strong positive correlation with their phenolics and flavonoids contents 5,6,7,8,9,10 .…”

Section: Introductionmentioning

confidence: 99%

“…that are effective against both gram-negative and gram-positive bacteria, but these synthetic antibiotics show many side effects like increased oxidative stress, loss of appetite, diarrhea, indigestion or stomach pain 11 . Earlier reports are indicating that many plant extracts have rich antimicrobial as well as antioxidant properties 8,12 . Plant-derived natural compounds occupied a major portion of the pharmaceutical market just because of their fewer side effects, cost efficiency, and eco-friendly nature relative to the modern semi-synthetic or synthetic drugs.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparativein vitroantioxidant and antibacterial activities of leaf extract fractions of Crimson bottlebrush,Callistemon citrinus(Curtis.) Skeels

Ghosh

Goswami

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Objectives: The present study aimed to analyze a comparative in vitro free radical scavenging and antibacterial potentials of leaf aqueous and the successive extract fractions of Callistemon citrinus. Methods: For in vitro antioxidant activity assessments, 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity, Fe3+ ion reducing antioxidant power (FRAP) assay, and total antioxidant capacity of the extracts were tested. Antibacterial potentials were tested through Agar well diffusion method using both gram-positive and gram-negative bacterial strains. Results: Data indicate the polar successive aqueous fraction (AQF) possesses the highest free radicals scavenging capacity, with lowest EC50 (the required extract concentration to scavenge half of the free radicals) for DPPH and FRAP assays, and contains the highest total phenolics, flavonoids, total antioxidant capacity. Phenolics and flavonoids contents were positively correlated with the in vitro antioxidant activities. The antibacterial study indicates the petroleum ether and chloroform are suitable solvents for extracting antibacterial phytochemicals from C. citrinus leaves that are effective against both gram-positive and negative bacterial strains. Conclusion: The most polar fraction i.e. the successive aqueous extract fraction of C. citrinus leaves exhibited the highest antioxidant activities while the most non-polar petroleum ether extract fraction showed the highest antibacterial potentials thus these extract fractions might have therapeutic importance.

show abstract

Phytochemical Profiling and Pharmacological Evaluation of Leaf Extracts of Ruellia tuberosa L.: An In Vitro and In Silico Approach

Sharma

Kumar

Singh

et al. 2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

The present study was designed to appraise the photoprotective, antioxidant, and antibacterial bioactivities of Ruellia tuberosa leaves extracts (RtPE, RtChl, RtEA, RtAc, RtMe, and RtHMe). The results showed that the RtHMe extract of leaves of R. tuberosa was rich in total phenolic content i.e., 1.60 mgGAE/g dry extract, while TFC highest total flavonoid content was found in RtAc extract, i.e., 0.40 mgQE/g. RtMe showed effective antioxidant activity (%RSA: 58.16) at the concentration of 120 µL. RtMe, RtEA and RtHMe exhibited effective in vitro antibacterial activity against Gram‐negative bacteria (E. coli). In silico docking studies revealed that paucifloside (‐11.743 kcal/mol), indole‐3‐carboxaldehyde (‐7.519 kcal/mol), nuomioside (‐7.275 kcal/mol), isocassifolioside (‐6.992 kcal/mol) showed best docking score against PDB ID 2EX8 [penicillin binding protein 4 (dacB) from Escherichia coli, complexed with penicillin‐G], PDB ID 6CQA (E. coli dihydrofolate reductase protein complexed with inhibitor AMPQD), PDB ID 2Y2I [Penicillin‐binding protein 1B in complex with an alkyl boronate (ZA3)] and PDB ID 2OLV (from S. aureus), respectively. Docked phytochemicals also showed good drug likeness properties.

show abstract

Comparative antioxidant and antimicrobial potentials of leaf successive extract fractions of poison bulb, Crinum asiaticum L.

Cited by 25 publications

References 48 publications

Effects of Various Preextraction Treatments of Crinum asiaticum Leaf on Its Anti-Inflammatory Activity and Chemical Properties

Effects of Various Preextraction Treatments of Crinum asiaticum Leaf on Its Anti-Inflammatory Activity and Chemical Properties

Comparativein vitroantioxidant and antibacterial activities of leaf extract fractions of Crimson bottlebrush,Callistemon citrinus(Curtis.) Skeels

Phytochemical Profiling and Pharmacological Evaluation of Leaf Extracts of Ruellia tuberosa L.: An In Vitro and In Silico Approach

Contact Info

Product

Resources

About